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{{Infobox_gene}}
'''Suppressor of cytokine signaling 2''' is a [[protein]] that in humans is encoded by the ''SOCS2'' [[gene]].<ref name="pmid9344848">{{cite journal |author1=Masuhara M |author2=Sakamoto H |author3=Matsumoto A |author4=Suzuki R |author5=Yasukawa H |author6=Mitsui K |author7=Wakioka T |author8=Tanimura S |author9=Sasaki A |author10=Misawa H |author11=Yokouchi M |author12=Ohtsubo M |author13=Yoshimura A | title = Cloning and characterization of novel CIS family genes | journal = Biochem Biophys Res Commun | volume = 239 | issue = 2 | pages = 439–46 |date=November 1997 | pmid = 9344848 | pmc =  | doi = 10.1006/bbrc.1997.7484 }}</ref><ref name="pmid9266833">{{cite journal |author1=Minamoto S |author2=Ikegame K |author3=Ueno K |author4=Narazaki M |author5=Naka T |author6=Yamamoto H |author7=Matsumoto T |author8=Saito H |author9=Hosoe S |author10=Kishimoto T | title = Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3 | journal = Biochem Biophys Res Commun | volume = 237 | issue = 1 | pages = 79–83 |date=September 1997 | pmid = 9266833 | pmc =  | doi = 10.1006/bbrc.1997.7080 }}</ref><ref name="entrez_ 8835">{{cite web | title = Entrez Gene: SOCS2 suppressor of cytokine signaling 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8835| accessdate = }}</ref>
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as [[suppressor of cytokine signalling]] (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including [[erythropoietin]], [[Granulocyte macrophage colony-stimulating factor|GM-CSF]], [[Interleukin 10|IL10]] and [[interferon-gamma]] (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of [[insulin-like growth factor 1 receptor]] (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.<ref name="pmid9727029">{{cite journal |author1=Dey BR |author2=Spence SL |author3=Nissley P |author4=Furlanetto RW | title = Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor | journal = J. Biol. Chem. | volume = 273 | issue = 37 | pages = 24095–101 |date=September 1998 | pmid = 9727029 | doi = 10.1074/jbc.273.37.24095 | url =  }}</ref> [[Knockout mouse|Knockout]] studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.<ref name="entrez_ 8835"/><ref name="pmid12040024">{{cite journal |author1=Greenhalgh CJ |author2=Bertolino P |author3=Asa SL |author4=Metcalf D |author5=Corbin JE |author6=Adams TE |author7=Davey HW |author8=Nicola NA |author9=Hilton DJ |author10=Alexander WS | title = Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b) | journal = Mol. Endocrinol. | volume = 16 | issue = 6 | pages = 1394–406 |date=June 2002 | pmid = 12040024 | doi = 10.1210/me.16.6.1394 | url =  }}</ref>
==Interactions==
SOCS2 has been shown to [[Protein-protein interaction|interact]] with [[insulin-like growth factor 1 receptor]]<ref name=pmid9727029 /> and [[erythropoietin receptor]].<ref name=pmid11781573>{{cite journal |last=Eyckerman |first=S |authorlink= |author2=Verhee A |author3=der Heyden J V |author4=Lemmens I |author5=Ostade X V |author6=Vandekerckhove J |author7=Tavernier J  |date=Dec 2001 |title=Design and application of a cytokine-receptor-based interaction trap |journal=Nat. Cell Biol. |volume=3 |issue=12 |pages=1114–9 |publisher= |location = England| issn = 1465-7392| pmid = 11781573 |doi = 10.1038/ncb1201-1114 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
==References==
{{Reflist|2}}
==Further reading==
{{Refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Lopaczynski W |title=Differential regulation of signaling pathways for insulin and insulin-like growth factor I. |journal=Acta Biochim. Pol. |volume=46 |issue= 1 |pages= 51–60 |year= 1999 |pmid= 10453981 |doi=  }}
*{{cite journal  |author1=Wang J |author2=Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423–7 |year= 2002 |pmid= 11835308 |doi=10.1002/jnr.10145  }}
*{{cite journal  |vauthors=Kile BT, Schulman BA, Alexander WS, etal |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235–41 |year= 2002 |pmid= 12076535 |doi=10.1016/S0968-0004(02)02085-6  }}
*{{cite journal  |author1=Pezet A |author2=Buteau H |author3=Kelly PA |author4=Edery M |title=The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. |journal=Mol. Cell. Endocrinol. |volume=129 |issue= 2 |pages= 199–208 |year= 1997 |pmid= 9202403 |doi=10.1016/S0303-7207(97)00063-4  }}
*{{cite journal  |author1=Dey BR |author2=Spence SL |author3=Nissley P |author4=Furlanetto RW |title=Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 24095–101 |year= 1998 |pmid= 9727029 |doi=10.1074/jbc.273.37.24095  }}
*{{cite journal  |author1=Pezet A |author2=Favre H |author3=Kelly PA |author4=Edery M |title=Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24497–502 |year= 1999 |pmid= 10455112 |doi=10.1074/jbc.274.35.24497  }}
*{{cite journal  |author1=Yandava CN |author2=Pillari A |author3=Drazen JM |title=Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. |journal=Genomics |volume=61 |issue= 1 |pages= 108–11 |year= 1999 |pmid= 10512686 |doi= 10.1006/geno.1999.5937 }}
*{{cite journal  |author1=Ram PA |author2=Waxman DJ |title=SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35553–61 |year= 2000 |pmid= 10585430 |doi=10.1074/jbc.274.50.35553  }}
*{{cite journal  |vauthors=Metcalf D, Greenhalgh CJ, Viney E, etal |title=Gigantism in mice lacking suppressor of cytokine signalling-2. |journal=Nature |volume=405 |issue= 6790 |pages= 1069–73 |year= 2000 |pmid= 10890450 |doi= 10.1038/35016611 }}
*{{cite journal  |author1=Shen X |author2=Hong F |author3=Nguyen VA |author4=Gao B |title=IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 132–6 |year= 2000 |pmid= 11034314 |doi=10.1016/S0014-5793(00)01905-0  }}
*{{cite journal  |vauthors=Eyckerman S, Verhee A, der Heyden JV, etal |title=Design and application of a cytokine-receptor-based interaction trap. |journal=Nat. Cell Biol. |volume=3 |issue= 12 |pages= 1114–9 |year= 2002 |pmid= 11781573 |doi= 10.1038/ncb1201-1114 }}
*{{cite journal  |vauthors=Schultheis B, Carapeti-Marootian M, Hochhaus A, etal |title=Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. |journal=Blood |volume=99 |issue= 5 |pages= 1766–75 |year= 2002 |pmid= 11861294 |doi=10.1182/blood.V99.5.1766  }}
*{{cite journal  |author1=Blumenstein M |author2=Bowen-Shauver JM |author3=Keelan JA |author4=Mitchell MD |title=Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 3 |pages= 1094–7 |year= 2002 |pmid= 11889171 |doi=10.1210/jc.87.3.1094  }}
*{{cite journal  |vauthors=Biener E, Maurice S, Sandowski Y, etal |title=Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization. |journal=Protein Expr. Purif. |volume=25 |issue= 2 |pages= 305–12 |year= 2003 |pmid= 12135564 |doi=10.1016/S1046-5928(02)00013-X  }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
}}
{{Refend}}
{{PDB Gallery|geneid=8835}}
==External links==
* {{MeshName|SOCS2+protein,+human}}
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{{JAK-STAT signaling pathway}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SOCS2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2c9w.
| PDB = {{PDB2|2c9w}}
| Name = Suppressor of cytokine signaling 2
| HGNCid = 19382
| Symbol = SOCS2
| AltSymbols =; CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
| OMIM = 605117
| ECnumber = 
| Homologene = 2880
| MGIid = 1201787
| GeneAtlas_image1 = PBB_GE_SOCS2_203373_at_tn.png
| GeneAtlas_image2 = PBB_GE_SOCS2_203372_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005131 |text = growth hormone receptor binding}} {{GNF_GO|id=GO:0005148 |text = prolactin receptor binding}} {{GNF_GO|id=GO:0005159 |text = insulin-like growth factor receptor binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008269 |text = JAK pathway signal transduction adaptor activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0001558 |text = regulation of cell growth}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8835
    | Hs_Ensembl = ENSG00000120833
    | Hs_RefseqProtein = NP_003868
    | Hs_RefseqmRNA = NM_003877
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 92487729
    | Hs_GenLoc_end = 92494109
    | Hs_Uniprot = O14508
    | Mm_EntrezGene = 216233
    | Mm_Ensembl = ENSMUSG00000020027
    | Mm_RefseqmRNA = NM_007706
    | Mm_RefseqProtein = NP_031732
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 94815050
    | Mm_GenLoc_end = 94846509
    | Mm_Uniprot = Q548Q7
  }}
}}
'''Suppressor of cytokine signaling 2''', also known as '''SOCS2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SOCS2 suppressor of cytokine signaling 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8835| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.<ref name="entrez">{{cite web | title = Entrez Gene: SOCS2 suppressor of cytokine signaling 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8835| accessdate = }}</ref>
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Lopaczynski W |title=Differential regulation of signaling pathways for insulin and insulin-like growth factor I. |journal=Acta Biochim. Pol. |volume=46 |issue= 1 |pages= 51-60 |year= 1999 |pmid= 10453981 |doi=  }}
*{{cite journal  | author=Wang J, Campbell IL |title=Cytokine signaling in the brain: putting a SOCS in it? |journal=J. Neurosci. Res. |volume=67 |issue= 4 |pages= 423-7 |year= 2002 |pmid= 11835308 |doi=  }}
*{{cite journal  | author=Kile BT, Schulman BA, Alexander WS, ''et al.'' |title=The SOCS box: a tale of destruction and degradation. |journal=Trends Biochem. Sci. |volume=27 |issue= 5 |pages= 235-41 |year= 2002 |pmid= 12076535 |doi=  }}
*{{cite journal  | author=Pezet A, Buteau H, Kelly PA, Edery M |title=The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. |journal=Mol. Cell. Endocrinol. |volume=129 |issue= 2 |pages= 199-208 |year= 1997 |pmid= 9202403 |doi=  }}
*{{cite journal  | author=Minamoto S, Ikegame K, Ueno K, ''et al.'' |title=Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. |journal=Biochem. Biophys. Res. Commun. |volume=237 |issue= 1 |pages= 79-83 |year= 1997 |pmid= 9266833 |doi= 10.1006/bbrc.1997.7080 }}
*{{cite journal  | author=Masuhara M, Sakamoto H, Matsumoto A, ''et al.'' |title=Cloning and characterization of novel CIS family genes. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 2 |pages= 439-46 |year= 1997 |pmid= 9344848 |doi= 10.1006/bbrc.1997.7484 }}
*{{cite journal  | author=Dey BR, Spence SL, Nissley P, Furlanetto RW |title=Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 24095-101 |year= 1998 |pmid= 9727029 |doi=  }}
*{{cite journal  | author=Pezet A, Favre H, Kelly PA, Edery M |title=Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. |journal=J. Biol. Chem. |volume=274 |issue= 35 |pages= 24497-502 |year= 1999 |pmid= 10455112 |doi=  }}
*{{cite journal  | author=Yandava CN, Pillari A, Drazen JM |title=Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively. |journal=Genomics |volume=61 |issue= 1 |pages= 108-11 |year= 1999 |pmid= 10512686 |doi= 10.1006/geno.1999.5937 }}
*{{cite journal  | author=Ram PA, Waxman DJ |title=SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35553-61 |year= 2000 |pmid= 10585430 |doi=  }}
*{{cite journal  | author=Metcalf D, Greenhalgh CJ, Viney E, ''et al.'' |title=Gigantism in mice lacking suppressor of cytokine signalling-2. |journal=Nature |volume=405 |issue= 6790 |pages= 1069-73 |year= 2000 |pmid= 10890450 |doi= 10.1038/35016611 }}
*{{cite journal  | author=Shen X, Hong F, Nguyen VA, Gao B |title=IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 132-6 |year= 2000 |pmid= 11034314 |doi=  }}
*{{cite journal  | author=Eyckerman S, Verhee A, der Heyden JV, ''et al.'' |title=Design and application of a cytokine-receptor-based interaction trap. |journal=Nat. Cell Biol. |volume=3 |issue= 12 |pages= 1114-9 |year= 2002 |pmid= 11781573 |doi= 10.1038/ncb1201-1114 }}
*{{cite journal  | author=Schultheis B, Carapeti-Marootian M, Hochhaus A, ''et al.'' |title=Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism. |journal=Blood |volume=99 |issue= 5 |pages= 1766-75 |year= 2002 |pmid= 11861294 |doi=  }}
*{{cite journal  | author=Blumenstein M, Bowen-Shauver JM, Keelan JA, Mitchell MD |title=Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 3 |pages= 1094-7 |year= 2002 |pmid= 11889171 |doi=  }}
*{{cite journal  | author=Biener E, Maurice S, Sandowski Y, ''et al.'' |title=Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization. |journal=Protein Expr. Purif. |volume=25 |issue= 2 |pages= 305-12 |year= 2003 |pmid= 12135564 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}


{{protein-stub}}
{{Gene-12-stub}}
{{WikiDoc Sources}}

Revision as of 06:48, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[1][2][3]

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[4] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[3][5]

Interactions

SOCS2 has been shown to interact with insulin-like growth factor 1 receptor[4] and erythropoietin receptor.[6]

References

  1. ↑ Masuhara M; Sakamoto H; Matsumoto A; Suzuki R; Yasukawa H; Mitsui K; Wakioka T; Tanimura S; Sasaki A; Misawa H; Yokouchi M; Ohtsubo M; Yoshimura A (November 1997). "Cloning and characterization of novel CIS family genes". Biochem Biophys Res Commun. 239 (2): 439–46. doi:10.1006/bbrc.1997.7484. PMID 9344848.
  2. ↑ Minamoto S; Ikegame K; Ueno K; Narazaki M; Naka T; Yamamoto H; Matsumoto T; Saito H; Hosoe S; Kishimoto T (September 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochem Biophys Res Commun. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
  3. ↑ 3.0 3.1 "Entrez Gene: SOCS2 suppressor of cytokine signaling 2".
  4. ↑ 4.0 4.1 Dey BR; Spence SL; Nissley P; Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
  5. ↑ Greenhalgh CJ; Bertolino P; Asa SL; Metcalf D; Corbin JE; Adams TE; Davey HW; Nicola NA; Hilton DJ; Alexander WS (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Mol. Endocrinol. 16 (6): 1394–406. doi:10.1210/me.16.6.1394. PMID 12040024.
  6. ↑ Eyckerman, S; Verhee A; der Heyden J V; Lemmens I; Ostade X V; Vandekerckhove J; Tavernier J (Dec 2001). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. England. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. ISSN 1465-7392. PMID 11781573.

Further reading

  • Lopaczynski W (1999). "Differential regulation of signaling pathways for insulin and insulin-like growth factor I.". Acta Biochim. Pol. 46 (1): 51–60. PMID 10453981.
  • Wang J; Campbell IL (2002). "Cytokine signaling in the brain: putting a SOCS in it?". J. Neurosci. Res. 67 (4): 423–7. doi:10.1002/jnr.10145. PMID 11835308.
  • Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
  • Pezet A; Buteau H; Kelly PA; Edery M (1997). "The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor". Mol. Cell. Endocrinol. 129 (2): 199–208. doi:10.1016/S0303-7207(97)00063-4. PMID 9202403.
  • Dey BR; Spence SL; Nissley P; Furlanetto RW (1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". J. Biol. Chem. 273 (37): 24095–101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
  • Pezet A; Favre H; Kelly PA; Edery M (1999). "Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling". J. Biol. Chem. 274 (35): 24497–502. doi:10.1074/jbc.274.35.24497. PMID 10455112.
  • Yandava CN; Pillari A; Drazen JM (1999). "Radiation hybrid and cytogenetic mapping of SOCS1 and SOCS2 to chromosomes 16p13 and 12q, respectively". Genomics. 61 (1): 108–11. doi:10.1006/geno.1999.5937. PMID 10512686.
  • Ram PA; Waxman DJ (2000). "SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms". J. Biol. Chem. 274 (50): 35553–61. doi:10.1074/jbc.274.50.35553. PMID 10585430.
  • Metcalf D, Greenhalgh CJ, Viney E, et al. (2000). "Gigantism in mice lacking suppressor of cytokine signalling-2". Nature. 405 (6790): 1069–73. doi:10.1038/35016611. PMID 10890450.
  • Shen X; Hong F; Nguyen VA; Gao B (2000). "IL-10 attenuates IFN-alpha-activated STAT1 in the liver: involvement of SOCS2 and SOCS3". FEBS Lett. 480 (2–3): 132–6. doi:10.1016/S0014-5793(00)01905-0. PMID 11034314.
  • Eyckerman S, Verhee A, der Heyden JV, et al. (2002). "Design and application of a cytokine-receptor-based interaction trap". Nat. Cell Biol. 3 (12): 1114–9. doi:10.1038/ncb1201-1114. PMID 11781573.
  • Schultheis B, Carapeti-Marootian M, Hochhaus A, et al. (2002). "Overexpression of SOCS-2 in advanced stages of chronic myeloid leukemia: possible inadequacy of a negative feedback mechanism". Blood. 99 (5): 1766–75. doi:10.1182/blood.V99.5.1766. PMID 11861294.
  • Blumenstein M; Bowen-Shauver JM; Keelan JA; Mitchell MD (2002). "Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor". J. Clin. Endocrinol. Metab. 87 (3): 1094–7. doi:10.1210/jc.87.3.1094. PMID 11889171.
  • Biener E, Maurice S, Sandowski Y, et al. (2003). "Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization". Protein Expr. Purif. 25 (2): 305–12. doi:10.1016/S1046-5928(02)00013-X. PMID 12135564.
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External links



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