Mixed connective tissue disease medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
The treatment of patients with MCTD depends on type of internal organ involvement, phase of the disease, and rate of disease progression. Treatment strategies must follow conventional treatments that are used for similar problems in other [[Rheumatology|rheumatic]] diseases ([[systemic lupus erythematosus|SLE]], [[scleroderma]], [[polymyositis]]). Usually the treatment of patients with MCTD include low doses of [[Steroid|steroids]], [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[Immunosuppressive drug|immunosuppressive drugs]], and [[Biology|biologic]] agents. The treatment options in [[refractory]] cases or in severe clinical conditions include [[Antibody|immunoglobulins]], [[Chemotherapy|cytotoxic agents]], and [[Biology|biologic]] drugs. | |||
==Medical Therapy== | ==Medical Therapy== | ||
* The treatment of patients with MCTD | * The treatment of patients with MCTD depends on:<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | ||
** | ** Type of Internal organ involvement | ||
** Phase of the disease | ** Phase of the disease | ||
** Rate of progression | ** Rate of disease progression | ||
* Treatment strategies must follow conventional | * Treatment strategies must follow conventional treatments of similar problems in other [[Rheumatology|rheumatic]] diseases ([[systemic lupus erythematosus|SLE]], [[scleroderma]], [[polymyositis]]).<ref name="pmid16084325">{{cite journal |vauthors=Kim P, Grossman JM |title=Treatment of mixed connective tissue disease |journal=Rheum. Dis. Clin. North Am. |volume=31 |issue=3 |pages=549–65, viii |date=August 2005 |pmid=16084325 |doi=10.1016/j.rdc.2005.04.008 |url=}}</ref> | ||
* | ** For more information about treatment of [[systemic lupus erythematosus]], click '''[[Systemic lupus erythematosus medical therapy|here]]'''. | ||
* | ** For more information about treatment of [[scleroderma]], click '''[[Scleroderma medical therapy|here]]'''. | ||
* [[ | ** For more information about treatment of [[Polymyositis and dermatomyositis|polymyositis]], click '''[[Polymyositis and dermatomyositis medical therapy|here]]'''. | ||
* Usually the treatment of patients with MCTD include:<ref name="pmid24353496">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | |||
** Low doses of [[Steroid|steroids]] | |||
** [[Non-steroidal anti-inflammatory drug|Non-steroidal anti-inflammatory drugs]] ([[Non-steroidal anti-inflammatory drug|NSAIDs]]) | |||
** [[Immunosuppressive drug|Immunosuppressive drugs]] | |||
** [[Biology|Biologic]] agents ([[monoclonal antibodies]]) | |||
* The treatment options in [[refractory]] cases or in severe clinical conditions include:<ref name="pmid243534962">{{cite journal |vauthors=Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E |title=Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl |journal=Postepy Dermatol Alergol |volume=30 |issue=5 |pages=329–36 |date=October 2013 |pmid=24353496 |pmc=3858664 |doi=10.5114/pdia.2013.38365 |url=}}</ref> | |||
** [[Antibody|Immunoglobulins]] | |||
** [[Chemotherapy|Cytotoxic agents]] (such as [[cyclophosphamide]]) | |||
** [[Biology|Biologic]] drugs | |||
* [[Plasmapheresis]] combined with [[rituximab]] (a [[Monoclonal antibodies|monoclonal antibody]] anti-CD20 which can modulate the disease activity) may be a treatment option. | |||
==References== | ==References== | ||
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[[Category: | [[Category:Medicine]] | ||
[[Category:Up-To-Date]] | |||
[[Category:Rheumatology]] | |||
Latest revision as of 14:56, 7 May 2018
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Mixed connective tissue disease Microchapters |
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Differentiating Mixed connective tissue disease from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Mixed connective tissue disease medical therapy On the Web |
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American Roentgen Ray Society Images of Mixed connective tissue disease medical therapy |
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Directions to Hospitals Treating Mixed connective tissue disease |
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Risk calculators and risk factors for Mixed connective tissue disease medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
The treatment of patients with MCTD depends on type of internal organ involvement, phase of the disease, and rate of disease progression. Treatment strategies must follow conventional treatments that are used for similar problems in other rheumatic diseases (SLE, scleroderma, polymyositis). Usually the treatment of patients with MCTD include low doses of steroids, NSAIDs, immunosuppressive drugs, and biologic agents. The treatment options in refractory cases or in severe clinical conditions include immunoglobulins, cytotoxic agents, and biologic drugs.
Medical Therapy
- The treatment of patients with MCTD depends on:[1]
- Type of Internal organ involvement
- Phase of the disease
- Rate of disease progression
- Treatment strategies must follow conventional treatments of similar problems in other rheumatic diseases (SLE, scleroderma, polymyositis).[2]
- For more information about treatment of systemic lupus erythematosus, click here.
- For more information about treatment of scleroderma, click here.
- For more information about treatment of polymyositis, click here.
- Usually the treatment of patients with MCTD include:[1]
- Low doses of steroids
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Immunosuppressive drugs
- Biologic agents (monoclonal antibodies)
- The treatment options in refractory cases or in severe clinical conditions include:[3]
- Immunoglobulins
- Cytotoxic agents (such as cyclophosphamide)
- Biologic drugs
- Plasmapheresis combined with rituximab (a monoclonal antibody anti-CD20 which can modulate the disease activity) may be a treatment option.
References
- ↑ 1.0 1.1 Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.
- ↑ Kim P, Grossman JM (August 2005). "Treatment of mixed connective tissue disease". Rheum. Dis. Clin. North Am. 31 (3): 549–65, viii. doi:10.1016/j.rdc.2005.04.008. PMID 16084325.
- ↑ Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.