Mixed connective tissue disease

Jump to: navigation, search

Mixed connective tissue disease Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Mixed connective tissue disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

MCTD and Quality of Life

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Mixed connective tissue disease On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Mixed connective tissue disease

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

National Guidelines Clearinghouse

NICE Guidance

FDA on Mixed connective tissue disease

on Mixed connective tissue disease

Mixed connective tissue disease in the news

Blogs onMixed connective tissue disease</small>

Directions to Hospitals Treating Mixed connective tissue disease

Risk calculators and risk factors for Mixed connective tissue disease

WikiDoc Resources for Mixed connective tissue disease

Articles

Most recent articles on Mixed connective tissue disease

Most cited articles on Mixed connective tissue disease

Review articles on Mixed connective tissue disease

Articles on Mixed connective tissue disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Mixed connective tissue disease

Images of Mixed connective tissue disease

Photos of Mixed connective tissue disease

Podcasts & MP3s on Mixed connective tissue disease

Videos on Mixed connective tissue disease

Evidence Based Medicine

Cochrane Collaboration on Mixed connective tissue disease

Bandolier on Mixed connective tissue disease

TRIP on Mixed connective tissue disease

Clinical Trials

Ongoing Trials on Mixed connective tissue disease at Clinical Trials.gov

Trial results on Mixed connective tissue disease

Clinical Trials on Mixed connective tissue disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Mixed connective tissue disease

NICE Guidance on Mixed connective tissue disease

NHS PRODIGY Guidance

FDA on Mixed connective tissue disease

CDC on Mixed connective tissue disease

Books

Books on Mixed connective tissue disease

News

Mixed connective tissue disease in the news

Be alerted to news on Mixed connective tissue disease

News trends on Mixed connective tissue disease

Commentary

Blogs on Mixed connective tissue disease

Definitions

Definitions of Mixed connective tissue disease

Patient Resources / Community

Patient resources on Mixed connective tissue disease

Discussion groups on Mixed connective tissue disease

Patient Handouts on Mixed connective tissue disease

Directions to Hospitals Treating Mixed connective tissue disease

Risk calculators and risk factors for Mixed connective tissue disease

Healthcare Provider Resources

Symptoms of Mixed connective tissue disease

Causes & Risk Factors for Mixed connective tissue disease

Diagnostic studies for Mixed connective tissue disease

Treatment of Mixed connective tissue disease

Continuing Medical Education (CME)

CME Programs on Mixed connective tissue disease

International

Mixed connective tissue disease en Espanol

Mixed connective tissue disease en Francais

Business

Mixed connective tissue disease in the Marketplace

Patents on Mixed connective tissue disease

Experimental / Informatics

List of terms related to Mixed connective tissue disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2], Jesus Rosario Hernandez, M.D. [3], Mahshid Mir, M.D. [4]

Synonyms and Keywords: MCTD; mixed connective tissue disorder; Sharp's syndrome

Overview

Mixed connective tissue disease (MCTD) or Sharp's syndrome is a human autoimmune disease in which the immune system attacks the body. MCTD combines features of polymyositis, systemic lupus erythematosus, and systemic scleroderma and is thus considered an overlap syndrome. MCTD commonly causes joint pain/swelling, Raynaud phenomenon, muscle inflammation, and scarring of the skin of the hand. It does not typically cause kidney disease or seizures. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody.[1]

Pathophysiology

There are no specific histologic findings that aid in the diagnosis of Mixed Connective Tissue Disorder as a separate autoimmune disease. For example, nephritis in MCTD is usually indistinguishable from lupus nephritis.

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Mixed Connective Tissue Disease from other Diseases

Epidemiology and Demographics

Age

Gender

Race

Risk Factors

Natural History, Complications and Prognosis

Cardiovascular abnormalities associated with mixed connective tissue disease are rare. Presence of any of the complications listed below indicates unfavorable prognosis;

Diagnosis

Diagnostic Criteria

Symptoms

Physical examination

Gallery

Trunk
Extremities

Laboratory Findings

  • Elevated serum level of muscle enzymes (creatine kinase)
  • MCTD is characterized by anti–U1 small nuclear RNP positivity.

Imaging Findings

    • Myogenic pattern on electromyogram

Other Diagnostic Studies

    • Hypomotility or dilatation of esophagus

References

  1. Venables PJ. Mixed connective tissue disease. Lupus. 2006;15(3):132-7. PMID 1663436
  2. Jang J J, Olin J W, Fuster V. A teenager with mixed connective tissue disease presenting with an acute coronary syndrome. Vascular Medicine; 2004, Vol. 9 Issue 1, 31-34

Linked-in.jpg