Mixed connective tissue disease

Jump to: navigation, search

WikiDoc Resources for

Mixed connective tissue disease

Articles

Most recent articles on Mixed connective tissue disease

Most cited articles on Mixed connective tissue disease

Review articles on Mixed connective tissue disease

Articles on Mixed connective tissue disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Mixed connective tissue disease

Images of Mixed connective tissue disease

Photos of Mixed connective tissue disease

Podcasts & MP3s on Mixed connective tissue disease

Videos on Mixed connective tissue disease

Evidence Based Medicine

Cochrane Collaboration on Mixed connective tissue disease

Bandolier on Mixed connective tissue disease

TRIP on Mixed connective tissue disease

Clinical Trials

Ongoing Trials on Mixed connective tissue disease at Clinical Trials.gov

Trial results on Mixed connective tissue disease

Clinical Trials on Mixed connective tissue disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Mixed connective tissue disease

NICE Guidance on Mixed connective tissue disease

NHS PRODIGY Guidance

FDA on Mixed connective tissue disease

CDC on Mixed connective tissue disease

Books

Books on Mixed connective tissue disease

News

Mixed connective tissue disease in the news

Be alerted to news on Mixed connective tissue disease

News trends on Mixed connective tissue disease

Commentary

Blogs on Mixed connective tissue disease

Definitions

Definitions of Mixed connective tissue disease

Patient Resources / Community

Patient resources on Mixed connective tissue disease

Discussion groups on Mixed connective tissue disease

Patient Handouts on Mixed connective tissue disease

Directions to Hospitals Treating Mixed connective tissue disease

Risk calculators and risk factors for Mixed connective tissue disease

Healthcare Provider Resources

Symptoms of Mixed connective tissue disease

Causes & Risk Factors for Mixed connective tissue disease

Diagnostic studies for Mixed connective tissue disease

Treatment of Mixed connective tissue disease

Continuing Medical Education (CME)

CME Programs on Mixed connective tissue disease

International

Mixed connective tissue disease en Espanol

Mixed connective tissue disease en Francais

Business

Mixed connective tissue disease in the Marketplace

Patents on Mixed connective tissue disease

Experimental / Informatics

List of terms related to Mixed connective tissue disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor: Cafer Zorkun, M.D., Ph.D. [2]

Synonyms and keywords: MCTD; mixed connective tissue disorder; Sharp's syndrome

Overview

Mixed connective tissue disease (MCTD) or Sharp's syndrome is a human autoimmune disease in which the immune system attacks the body. MCTD combines features of polymyositis, systemic lupus erythematosus, and systemic scleroderma and is thus considered an overlap syndrome. MCTD commonly causes joint pain/swelling, Raynaud phenomenon, muscle inflammation, and scarring of the skin of the hand. It does not typically cause kidney disease or seizures. Distinguishing laboratory characteristics are a positive, speckled anti-nuclear antibody and an anti-U1-RNP antibody.[1]

Pathophysiology

There are no specific histologic findings that aid in the diagnosis of Mixed Connective Tissue Disorder as a separate autoimmune disease. For example, nephritis in MCTD is usually indistinguishable from lupus nephritis.

Diagnosis

It is characterized by -

Mixed Connective Tissue Disorder Findings

A. Systemic lupus erythematosus–like findings

B. Progressive Systemic Sclerosis –like findings

  • Sclerodactyly
  • Pulmonary fibrosis, restrictive changes of the lung (forced vital capacity <80% of predicted), or reduced carbon monoxide diffusing capacity (<70% of predicted)
  • Hypomotility or dilatation of esophagus

C. Polymyositis-like findings

  • Muscle weakness
  • Elevated serum level of muscle enzymes (creatine kinase)
  • Myogenic pattern on electromyogram

MCTD is characterized by anti–U1 small nuclear RNP positivity.

Cardiac Involvement in MCTD

Cardiovascular abnormalities associated with mixed connective tissue disease are rare. Presence of any of the complications listed below indicates unfavorable prognosis;

References

  1. Venables PJ. Mixed connective tissue disease. Lupus. 2006;15(3):132-7. PMID 1663436
  2. Jang J J, Olin J W, Fuster V. A teenager with mixed connective tissue disease presenting with an acute coronary syndrome. Vascular Medicine; 2004, Vol. 9 Issue 1, 31-34
nl:Mixed connective tissue diseasesv:Mixed Connective Tissue Disease



Navigation WikiDoc | WikiPatient | Up To Date Pages | Recently Edited Pages | Recently Added Pictures

Table of Contents In Alphabetical Order | By Individual Diseases | Signs and Symptoms | Physical Examination | Lab Tests | Drugs

Editor Tools Become an Editor | Editors Help Menu | Create a Page | Edit a Page | Upload a Picture or File | Printable version | Permanent link | Maintain Pages | What Pages Link Here
There is no pharmaceutical or device industry support for this site and we need your viewer supported Donations | Editorial Board | Governance | Licensing | Disclaimers | Avoid Plagiarism | Policies
Linked-in.jpg