Mixed connective tissue disease epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shaghayegh Habibi, M.D.[2]
Overview
The incidence of mixed connective tissue disease is approximately 2.7 per 100,000 individuals per year. A nationwide study on MCTD showed the prevalence of mixed connective tissue disease was 2.7 per 100,000 individuals in Japan and 3.8 per 100,000 individuals in Norway. In MCTD, the mortality rate is nearly 10.4% over the period of 13-15 years. It is usually diagnosed during childhood and is more frequent among black and Asian population. The female to male ratio is approximately 10 to 1.
Epidemiology and Demographics
Incidence
- The incidence of mixed connective tissue disease is approximately 2.7 per 100,000 individuals per year.[1]
Prevalence
- A population-based epidemiology study in Norway demonstrates the prevalence of adult-onset MCTD is 3.8 per 100,000 individuals.[2]
- A nationwide study on MCTD in Japan showed the prevalence of mixed connective tissue disease was 2.7 per 100,000.[3]
Mortality rate
- In MCTD, the mortality rate is nearly 10.4% over the period of 13-15 years.[4]
Age
- Mixed connective tissue disease is usually diagnosed during childhood. It usually starts between 2 and 16 years of age (mean age is 11 years old).[1]
Race
- MCTD is more frequent among black and Asian population.[5]
Gender
- Female are more frequently affected by MCTD than male. The female to male ratio is approximately 10 to 1.[6]
References
- ↑ 1.0 1.1 Latuśkiewicz-Potemska J, Zygmunt A, Biernacka-Zielińska M, Stańczyk J, Smolewska E (October 2013). "Mixed connective tissue disease presenting with progressive scleroderma symptoms in a 10-year-old girl". Postepy Dermatol Alergol. 30 (5): 329–36. doi:10.5114/pdia.2013.38365. PMC 3858664. PMID 24353496.
- ↑ Gunnarsson R, Hetlevik SO, Lilleby V, Molberg Ø (February 2016). "Mixed connective tissue disease". Best Pract Res Clin Rheumatol. 30 (1): 95–111. doi:10.1016/j.berh.2016.03.002. PMID 27421219.
- ↑ Kanno A, Nishimori I, Masamune A, Kikuta K, Hirota M, Kuriyama S, Tsuji I, Shimosegawa T (August 2012). "Nationwide epidemiological survey of autoimmune pancreatitis in Japan". Pancreas. 41 (6): 835–9. doi:10.1097/MPA.0b013e3182480c99. PMID 22466167.
- ↑ Ungprasert P, Wannarong T, Panichsillapakit T, Cheungpasitporn W, Thongprayoon C, Ahmed S, Raddatz DA (February 2014). "Cardiac involvement in mixed connective tissue disease: a systematic review". Int. J. Cardiol. 171 (3): 326–30. doi:10.1016/j.ijcard.2013.12.079. PMID 24433611.
- ↑ Missounga L, Ba JI, Nseng Nseng Ondo IR, Nziengui Madjinou M, Malekou D, Mouendou Mouloungui EG, Nzengue EE, Boguikouma JB, Kombila M (2017). "[Mixed connective tissue disease: prevalence and clinical characteristics in African black, study of 7 cases in Gabon and review of the literature]". Pan Afr Med J (in French). 27: 162. doi:10.11604/pamj.2017.27.162.12572. PMC 5567953. PMID 28904690. Vancouver style error: initials (help)
- ↑ Ungprasert P, Crowson CS, Chowdhary VR, Ernste FC, Moder KG, Matteson EL (December 2016). "Epidemiology of Mixed Connective Tissue Disease, 1985-2014: A Population-Based Study". Arthritis Care Res (Hoboken). 68 (12): 1843–1848. doi:10.1002/acr.22872. PMC 5426802. PMID 26946215.