Purpura pathophysiology: Difference between revisions
Jump to navigation
Jump to search
(Created page with "__NOTOC__ {{Purpura}} Please help WikiDoc by adding content here. It's easy! Click here to learn about editing. ==References== {{Reflist|2}}...") |
Kiran Singh (talk | contribs) |
||
| (6 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Purpura}} | {{Purpura}} | ||
{{CMG}} | |||
==Pathophysiology== | |||
Purpura is a common and unspecific symptom, however the underlying mechanism commonly involves one of the following; | |||
*[[Platelet|Platelet disorders]] | |||
**[[idiopathic thrombocytopenic purpura|Primary thrombocytopenic purpura]] | |||
**Secondary thrombocytopenic purpura | |||
*Vascular disorders | |||
**Microvascular injury, as seen in senile (old age) purpura, when blood vessels are more easily damaged | |||
**Hypertensive states | |||
**Deficient vascular support | |||
**[[Vasculitis]], as in the case of [[Henoch-Schönlein purpura]] | |||
*[[Coagulopathy|Coagulation disorders]] | |||
**[[Disseminated intravascular coagulation]] (DIC) | |||
There are also cases of psychogenic purpura described in the medical literature,<ref name="pmid10069314">{{cite journal |author=Anderson JE, DeGoff W, McNamara M |title=Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature |journal=Pediatric emergency care |volume=15 |issue=1 |pages=47-8 |year=1999 |pmid=10069314 |doi=}}</ref> some claimed to be due to "autoerythrocyte sensitization". Other studies<ref name="pmid8340191">{{cite journal |author=Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P, et al. |title=Psychogenic purpura with abnormallt cutaney increased tPA dependeny |journous fibrinolytic activital=Int J Dermatol |volume=32| issue=7 |pages=521-3 |year=1993 |pmid=8340191 |doi=}}</ref> suggest, that local (cutaneous) activity of [[tPA]] can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of [[fibrin]] clots, and resultant bleeding. | |||
==References== | ==References== | ||
{{Reflist|2}} | |||
[[Category:Needs overview]] | |||
[[Category:Needs | |||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Physical examination]] | [[Category:Physical examination]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
{{WH}} | |||
{{WS}} | |||
Latest revision as of 18:47, 12 June 2015
|
Purpura Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Purpura pathophysiology On the Web |
|
American Roentgen Ray Society Images of Purpura pathophysiology |
|
Risk calculators and risk factors for Purpura pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Pathophysiology
Purpura is a common and unspecific symptom, however the underlying mechanism commonly involves one of the following;
- Platelet disorders
- Primary thrombocytopenic purpura
- Secondary thrombocytopenic purpura
- Vascular disorders
- Microvascular injury, as seen in senile (old age) purpura, when blood vessels are more easily damaged
- Hypertensive states
- Deficient vascular support
- Vasculitis, as in the case of Henoch-Schönlein purpura
- Coagulation disorders
There are also cases of psychogenic purpura described in the medical literature,[1] some claimed to be due to "autoerythrocyte sensitization". Other studies[2] suggest, that local (cutaneous) activity of tPA can be increased in psychogenic purpura, leading to substantial amounts of localized plasmin activity, rapid degradation of fibrin clots, and resultant bleeding.
References
- ↑ Anderson JE, DeGoff W, McNamara M (1999). "Autoerythrocyte sensitization (psychogenic purpura): a case report and review of the literature". Pediatric emergency care. 15 (1): 47–8. PMID 10069314.
- ↑ Lotti T, Benci M, Sarti MG, Teofoli P, Senesi C, Bonan P; et al. (1993). "Psychogenic purpura with abnormallt cutaney increased tPA dependeny". 32 (7): 521–3. PMID 8340191. Unknown parameter
|journous fibrinolytic activital=ignored (help)