Tuaminoheptane

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Tuaminoheptane
Names
	IUPAC name Heptan-2-amine
Identifiers
CAS Number	123-82-0 ; 6240-90-0 R ; 44745-29-1 S ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL123693 ;
ChemSpider	5401 ; 5360930 R ; 2016267 S ;
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D07371 ;
MeSH	tuamine
PubChem CID	5603; 6992808 R; 2734517 S;
UNII	Z0420GYD84 ;
	InChI InChI=1S/C7H17N/c1-3-4-5-6-7(2)8/h7H,3-6,8H2,1-2H3 Key: VSRBKQFNFZQRBM-UHFFFAOYSA-N ;
	SMILES CCCCCC(C)N;
Properties
Chemical formula	C7H17N
Molar mass	115.22 g·mol−1
Hazards
Related compounds
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tuaminoheptane (or tuamine) is a nasal decongestant drug which is a sympathomimetic stimulant and vasoconstrictor.^[2] However, it can cause skin irritation,^[3] which limits its usefulness as a nasal decongestant. Oral preparations were once available, but are no longer produced. Side effects associated with the use of tuaminoheptane can include shortness of breath, tachycardia and hypertension.

Tuaminoheptane is on the 2011 list of prohibited substances published by the World Anti-Doping Agency.

References

↑ "tuamine - Compound Summary". USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. Retrieved 31 May 2012.
↑ Delicado, E. G.; Fideu, M. D.; Miras-Portugal, M. T.; Pourrias, B.; Aunis, D. (1990). "Effect of tuamine, heptaminol and two analogues on uptake and release of catecholamines in cultured chromaffin cells". Biochemical Pharmacology. 40 (4): 821–825. doi:10.1016/0006-2952(90)90322-C. PMID 2386550.
↑ Raoux, M.; Colomban, C.; Delmas, P.; Crest, M. (2007). "The amine-containing cutaneous irritant heptylamine inhibits the volume-regulated anion channel and mobilizes intracellular calcium in normal human epidermal keratinocytes". Molecular Pharmacology. 71 (6): 1685–1694. doi:10.1124/mol.106.033324. PMID 17384225.

Template:Stimulants

[1] "tuamine - Compound Summary". USA: National Center for Biotechnology Information. 25 March 2005. Identification and Related Records. Retrieved 31 May 2012.

[2] Delicado, E. G.; Fideu, M. D.; Miras-Portugal, M. T.; Pourrias, B.; Aunis, D. (1990). "Effect of tuamine, heptaminol and two analogues on uptake and release of catecholamines in cultured chromaffin cells". Biochemical Pharmacology. 40 (4): 821–825. doi:10.1016/0006-2952(90)90322-C. PMID 2386550.

[3] Raoux, M.; Colomban, C.; Delmas, P.; Crest, M. (2007). "The amine-containing cutaneous irritant heptylamine inhibits the volume-regulated anion channel and mobilizes intracellular calcium in normal human epidermal keratinocytes". Molecular Pharmacology. 71 (6): 1685–1694. doi:10.1124/mol.106.033324. PMID 17384225.

[1]

[2]

[3]

v t e Decongestants and other nasal preparations (R01)
Topical: sympathomimetics, plain	Cyclopentamine - Ephedrine - Phenylephrine - Oxymetazoline - Tetryzoline - Xylometazoline - Naphazoline - Tramazoline - Metizoline - Tuaminoheptane - Fenoxazoline - Tymazoline - Epinephrine
Topical: antiallergic agents, excluding corticosteroids	Cromoglicic acid - Levocabastine - Azelastine - Antazoline - Spaglumic acid - Thonzylamine - Nedocromil - Olopatadine
Topical: corticosteroids	Beclometasone - Prednisolone - Dexamethasone - Flunisolide - Budesonide - Betamethasone - Tixocortol - Fluticasone - Mometasone furoate - Triamcinolone - Ciclesonide
Topical: other nasal preparations	Calcium hexamine thiocyanate - Retinol - Ipratropium bromide - Ritiometan - Mupirocin - Hexamidine - Framycetin
Systemic use: Sympathomimetics	Phenylpropanolamine - Pseudoephedrine - Phenylephrine

Tuaminoheptane

Overview

See also

References

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Names

IUPAC name Heptan-2-amine^[1]
Identifiers
CAS Number	123-82-0^Y 6240-90-0 R^Y 44745-29-1 S^Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL123693^Y
ChemSpider	5401^Y 5360930 R^Y 2016267 S^Y
ECHA InfoCard	Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
KEGG	D07371^Y
MeSH	tuamine
PubChem CID	5603 6992808 R 2734517 S
UNII	Z0420GYD84^Y
InChI InChI=1S/C7H17N/c1-3-4-5-6-7(2)8/h7H,3-6,8H2,1-2H3^Y Key: VSRBKQFNFZQRBM-UHFFFAOYSA-N^Y
SMILES CCCCCC(C)N
Properties
Chemical formula	C₇H₁₇N
Molar mass	115.22 g·mol⁻¹
Hazards
Related compounds
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references