Sandbox/00041

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▸ Click on the following categories to expand treatment regimens.[1][2][3]

Cutaneous Anthrax Without Systemic Involvement

  ▸  Adult Patients

  ▸  Pediatric Patients

  ▸  Pregnant Patients

Systemic Anthrax with Possible/Confirmed Meningitis

  ▸  Adult Patients

  ▸  Pediatric Patients

  ▸  Pregnant Patients

Systemic Anthrax Without Meningitis

  ▸  Adult Patients

  ▸  Pediatric Patients

  ▸  Pregnant Patients

Cutaneous Anthrax, Adult Patients
Preferred Regimen
Ciprofloxacin 500 mg PO q12h
OR
Levofloxacin 750 mg PO q24h
OR
Moxifloxacin 400 mg PO q24h
OR
Doxycycline 100 mg PO q12h
Alternative Regimen
Clindamycin 600 mg PO q8h
OR
Penicillin VK 500 mg PO q6h
OR
Amoxicillin 1 g PO q8h
Cutaneous Anthrax, Pediatric Patients
Preferred Regimen
Ciprofloxacin 30 mg/kg/day PO q12h, max: 500 mg/dose
OR
Levofloxacin 16 mg/kg/day PO q12h, max: 250 mg/dose (<50 kg)
OR
Levofloxacin 500 mg PO q24h (≥50 kg)
OR
Doxycycline 4.4 mg/kg/day PO q12h, max: 100 mg/dose (<45 kg)
OR
Doxycycline 100 mg/dose PO q12h (≥45 kg)
Alternative Regimen
Clindamycin 30 mg/kg/day PO q8h, max: 600 mg/dose
OR
Penicillin VK 50–75 mg/kg/day PO q6–8h
OR
Amoxicillin 75 mg/kg/day PO q8h, max: 1 g/dose
Cutaneous Anthrax, Pregnant Patients
Preferred Regimen
Ciprofloxacin 500 mg PO q12h
Systemic Anthrax with Meningitis, Adult Patients
Preferred Regimen
Ciprofloxacin 400 mg IV q8h
OR
Levofloxacin 750 mg IV q24h
OR
Moxifloxacin 400 mg IV q24h
PLUS
Meropenem 2 g IV q8h
OR
Imipenem 1 g IV q6h
OR
Doripenem 500 mg IV q8h
PLUS
Linezolid 600 mg IV q12h
OR
Clindamycin 900 mg IV q8h
OR
Rifampin 600 mg IV q12h
OR
Chloramphenicol 1 g IV q6–8h
Alternative Regimen
Ciprofloxacin 400 mg IV q8h
OR
Levofloxacin 750 mg IV q24h
OR
Moxifloxacin 400 mg IV q24h
PLUS
Penicillin G 4 MU IV q4h
OR
Ampicillin 3 g IV q6h
PLUS
Linezolid 600 mg IV q12h
OR
Clindamycin 900 mg IV q8h
OR
Rifampin 600 mg IV q12h
OR
Chloramphenicol 1 g IV q6–8h
Systemic Anthrax with Meningitis, Pediatric Patients
Preferred Regimen
Ciprofloxacin 30 mg/kg/day IV q8h, max: 400 mg/dose
OR
Levofloxacin 20 mg/kg/day IV q12h, max: 250 mg/dose (<50 kg)
OR
Levofloxacin 500 mg IV q24h (≥50 kg)
OR
Meropenem 60 mg/kg/day IV q12h, max: 2 g/dose
OR
Imipenem/Cilastatin 100 mg/kg/day IV q6h, max: 1 g/dose
OR
Vancomycin 60 mg/kg/day IV q8h
PLUS
Clindamycin 30 mg/kg/day PO q8h, max: 600 mg/dose
OR
Linezolid 30 mg/kg/day IV q8h, max: 1 g/dose (<12 yr)
OR
Linezolid 30 mg/kg/day IV q12h, max: 600 mg/dose (≥12 yr)
OR
Doxycycline 4.4 mg/kg/day IV q12h, max: 100 mg/dose (<45 kg)
OR
Doxycycline 200 mg IV x1 then 100 mg IV q12h, max: 200 mg/dose (≥45 kg)
OR
Rifampin 20 mg/kg/day IV q12h, max: 300 mg/dose
Alternative Regimen
Penicillin G 0.4 MU/kg/day IV q4h, max: 4 MU/dose
OR
Ampicillin 200 mg/kg/day IV q6h, max: 900 mg/dose
PLUS
Clindamycin 30 mg/kg/day PO q8h, max: 600 mg/dose
OR
Linezolid 30 mg/kg/day IV q8h, max: 1 g/dose (<12 yr)
OR
Linezolid 30 mg/kg/day IV q12h, max: 600 mg/dose (≥12 yr)
OR
Doxycycline 4.4 mg/kg/day IV q12h, max: 100 mg/dose (<45 kg)
OR
Doxycycline 200 mg IV x1 then 100 mg IV q12h, max: 200 mg/dose (≥45 kg)
OR
Rifampin 20 mg/kg/day IV q12h, max: 300 mg/dose
Systemic Anthrax with Meningitis, Pregnant Patients
Preferred Regimen
Ciprofloxacin 400 mg IV q8h
PLUS
Clindamycin 900 mg IV q8h
OR
Rifampin 600 mg IV q12h
Alternative Regimen
Levofloxacin 750 mg IV q24h
OR
Meropenem 2 g IV q8h
OR
Penicillin G 4 MU IV q4h
OR
Ampicillin 3 g IV q6h
PLUS
Clindamycin 900 mg IV q8h
OR
Rifampin 600 mg IV q12h
Systemic Anthrax Without Meningitis, Adult Patients
Preferred Regimen
Ciprofloxacin 400 mg q8h
OR
Levofloxacin 750 mg q24h
OR
Moxifloxacin 400 mg PO q24h
OR
Meropenem 2 g q8h
OR
Imipenem 1 g IV q6h
OR
Doripenem 500 mg q8h
OR
Vancomycin 60 mg/kg/day IV q8h, trough: 15–20 μg/mL
PLUS
Clindamycin 900 mg q8h
OR
Linezolid 600 mg q12h
OR
Doxycycline 200 mg x1 then 100 mg IV q12h
OR
Rifampin 600 mg q12h
Alternative Regimen
Penicillin G 4 MU IV q4h
OR
Ampicillin 3 g IV q6h
PLUS
Clindamycin 900 mg q8h
OR
Linezolid 600 mg q12h
OR
Doxycycline 200 mg x1 then 100 mg IV q12h
OR
Rifampin 600 mg q12h
Systemic Anthrax Without Meningitis, Pediatric Patients
Preferred Regimen
Ciprofloxacin 30 mg/kg/day IV q8h, max: 400 mg/dose
OR
Levofloxacin 16 mg/kg/day IV q12h, max: 250 mg/dose (<50 kg)
OR
Levofloxacin 500 mg IV q24h (≥50 kg)
OR
Moxifloxacin 12 mg/kg/day IV q12h, max: 200 mg/dose (3 mo–2 yr)
OR
Moxifloxacin 10 mg/kg/day IV q12h, max: 200 mg/dose (2 yr–5 yr)
OR
Moxifloxacin 8 mg/kg/day IV q12h, max: 200 mg/dose (6 yr–11 yr)
OR
Moxifloxacin 8 mg/kg/day IV q12h, max: 200 mg/dose (12 yr–17 yr, <45 kg)
OR
Moxifloxacin 400 mg IV q24h (12 yr–17 yr, ≥45 kg)
PLUS
Meropenem 120 mg/kg/day IV q8h, max: 2 g/dose
OR
Imipenem/Cilastatin 100 mg/kg/day IV q6h, max: 1 g/dose
OR
Doripenem 120 mg/kg/day IV q8h, max: 1 g/dose
OR
Vancomycin 60 mg/kg/day IV q8h
PLUS
Linezolid 30 mg/kg/day IV q8h, max: 600 mg/dose (<12 yr)
OR
Linezolid 30 mg/kg/day IV q12h, max: 600 mg/dose (≥12 yr)
OR
Clindamycin 40 mg/kg/day IV q8h, max: 900 mg/dose
OR
Rifampin 20 mg/kg/day IV q12h, max: 300 mg/dose
OR
Chloramphenicol 100 mg/kg/day IV q6h
Alternative Regimen
Ciprofloxacin 30 mg/kg/day IV q8h, max: 400 mg/dose
OR
Levofloxacin 16 mg/kg/day IV q12h, max: 250 mg/dose (<50 kg)
OR
Levofloxacin 500 mg IV q24h (≥50 kg)
OR
Moxifloxacin 12 mg/kg/day IV q12h, max: 200 mg/dose (3 mo–2 yr)
OR
Moxifloxacin 10 mg/kg/day IV q12h, max: 200 mg/dose (2 yr–5 yr)
OR
Moxifloxacin 8 mg/kg/day IV q12h, max: 200 mg/dose (6 yr–11 yr)
OR
Moxifloxacin 8 mg/kg/day IV q12h, max: 200 mg/dose (12 yr–17 yr, <45 kg)
OR
Moxifloxacin 400 mg IV q24h (12 yr–17 yr, ≥45 kg)
PLUS
Penicillin G 0.4 MU/kg/day IV q4h, max: 4 MU/dose
OR
Ampicillin 400 mg/kg/day IV q6h, max: 3 g/dose
PLUS
Linezolid 30 mg/kg/day IV q8h, max: 600 mg/dose (<12 yr)
OR
Linezolid 30 mg/kg/day IV q12h, max: 600 mg/dose (≥12 yr)
OR
Clindamycin 40 mg/kg/day IV q8h, max: 900 mg/dose
OR
Rifampin 20 mg/kg/day IV q12h, max: 300 mg/dose
OR
Chloramphenicol 100 mg/kg/day IV q6h
Systemic Anthrax Without Meningitis, Pregnant Patients
Preferred Regimen
Ciprofloxacin 400 mg IV q8h
PLUS
Clindamycin 900 mg IV q8h
OR
Rifampin 600 mg IV q12h
Alternative Regimen
Levofloxacin 750 mg IV q24h
OR
Meropenem 2 g IV q8h
OR
Penicillin G 4 MU IV q4h
OR
Ampicillin 3 g IV q6h
PLUS
Clindamycin 900 mg IV q8h
OR
Rifampin 600 mg IV q12h

References

  1. Hendricks, Katherine A. (2014-02). "Centers for disease control and prevention expert panel meetings on prevention and treatment of anthrax in adults". Emerging Infectious Diseases. 20 (2). doi:10.3201/eid2002.130687. ISSN 1080-6059. PMC 3901462. PMID 24447897. Unknown parameter |coauthors= ignored (help); Check date values in: |date= (help)
  2. Bradley, John S. (2014-04-28). "Pediatric Anthrax Clinical Management". Pediatrics. doi:10.1542/peds.2014-0563. ISSN 1098-4275. PMID 24777226. Unknown parameter |coauthors= ignored (help)
  3. Meaney-Delman, Dana (2014-02). "Special considerations for prophylaxis for and treatment of anthrax in pregnant and postpartum women". Emerging Infectious Diseases. 20 (2). doi:10.3201/eid2002.130611. ISSN 1080-6059. PMC 3901460. PMID 24457117. Unknown parameter |coauthors= ignored (help); Check date values in: |date= (help)