Odorant-binding protein

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Pheromone/general odorant-binding protein
Identifiers
SymbolPBP_GOBP
PfamPF01395
InterProIPR006170
SCOP1c3z
SUPERFAMILY1c3z
odorant-binding protein 2A
File:3QME.pdb.jpg
Identifiers
SymbolOBP2A
Alt. symbolshOBPIIa, OBP
Entrez29991
HUGO23380
OMIM164320
RefSeqNM_014582
UniProtQ9NY56
Other data
LocusChr. 9 q34
odorant-binding protein 2B
Identifiers
SymbolOBP2B
Alt. symbolshOBPIIb
Entrez29989
HUGO23381
OMIM604606
RefSeqNM_014581
UniProtQ9NPH6
Other data
LocusChr. 9 q34

Odorant-binding proteins are abundant small soluble proteins secreted in the nasal mucus of many animal species and in the sensillar lymph of chemosensory sensilla of insects.

The olfactory receptors of terrestrial animals exist in an aqueous environment, yet detect odorants that are primarily hydrophobic. The aqueous solubility of hydrophobic odorants is greatly enhanced via odorant-binding proteins, which exist in the extracellular fluid surrounding the odorant receptors.[1] This family is composed of pheromone binding proteins (PBP), which are male-specific and associate with pheromone-sensitive neurons and general-odorant-binding proteins (GOBP).

These proteins were initially identified on the basis of their ability to bind with moderate-affinity radioactively labeled odorants.[2][3]

References

  1. Prestwich GD, Vogt RG, Lerner MR (1991). "Odorant-binding-protein subfamilies associate with distinct classes of olfactory receptor neurons in insects". J. Neurobiol. 22 (1): 74–84. doi:10.1002/neu.480220108. PMID 2010751.
  2. Pelosi P, Baldaccini NE, Pisanelli AM (January 1982). "Identification of a specific olfactory receptor for 2-isobutyl-3-methoxypyrazine". Biochem. J. 201 (1): 245–8. PMC 1163633. PMID 7082286.
  3. PDB ID: 1CI0 W. Shi, D.A. Ostrov, S.E. Gerchman, V. Graziano, H. Kycia, B. Studier, S.C. Almo, S.K. Burley, New York Structural GenomiX Research Consortium (NYSGXRC). The Structure of PNP Oxidase from S. cerevisiae

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