Non-24-hour sleep-wake syndrome

Jump to: navigation, search
Non-24-hour sleep-wake syndrome
ICD-10 G47.2
ICD-9 327.34

WikiDoc Resources for Non-24-hour sleep-wake syndrome

Articles

Most recent articles on Non-24-hour sleep-wake syndrome

Most cited articles on Non-24-hour sleep-wake syndrome

Review articles on Non-24-hour sleep-wake syndrome

Articles on Non-24-hour sleep-wake syndrome in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Non-24-hour sleep-wake syndrome

Images of Non-24-hour sleep-wake syndrome

Photos of Non-24-hour sleep-wake syndrome

Podcasts & MP3s on Non-24-hour sleep-wake syndrome

Videos on Non-24-hour sleep-wake syndrome

Evidence Based Medicine

Cochrane Collaboration on Non-24-hour sleep-wake syndrome

Bandolier on Non-24-hour sleep-wake syndrome

TRIP on Non-24-hour sleep-wake syndrome

Clinical Trials

Ongoing Trials on Non-24-hour sleep-wake syndrome at Clinical Trials.gov

Trial results on Non-24-hour sleep-wake syndrome

Clinical Trials on Non-24-hour sleep-wake syndrome at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Non-24-hour sleep-wake syndrome

NICE Guidance on Non-24-hour sleep-wake syndrome

NHS PRODIGY Guidance

FDA on Non-24-hour sleep-wake syndrome

CDC on Non-24-hour sleep-wake syndrome

Books

Books on Non-24-hour sleep-wake syndrome

News

Non-24-hour sleep-wake syndrome in the news

Be alerted to news on Non-24-hour sleep-wake syndrome

News trends on Non-24-hour sleep-wake syndrome

Commentary

Blogs on Non-24-hour sleep-wake syndrome

Definitions

Definitions of Non-24-hour sleep-wake syndrome

Patient Resources / Community

Patient resources on Non-24-hour sleep-wake syndrome

Discussion groups on Non-24-hour sleep-wake syndrome

Patient Handouts on Non-24-hour sleep-wake syndrome

Directions to Hospitals Treating Non-24-hour sleep-wake syndrome

Risk calculators and risk factors for Non-24-hour sleep-wake syndrome

Healthcare Provider Resources

Symptoms of Non-24-hour sleep-wake syndrome

Causes & Risk Factors for Non-24-hour sleep-wake syndrome

Diagnostic studies for Non-24-hour sleep-wake syndrome

Treatment of Non-24-hour sleep-wake syndrome

Continuing Medical Education (CME)

CME Programs on Non-24-hour sleep-wake syndrome

International

Non-24-hour sleep-wake syndrome en Espanol

Non-24-hour sleep-wake syndrome en Francais

Business

Non-24-hour sleep-wake syndrome in the Marketplace

Patents on Non-24-hour sleep-wake syndrome

Experimental / Informatics

List of terms related to Non-24-hour sleep-wake syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Non-24-hour sleep-wake syndrome, also termed circadian rhythm sleep disorder, free-running type, circadian arrhythmia, non-24-hour circadian rhythm disorder or hypernychthemeral syndrome, is a circadian rhythm sleep disorder. The International Classification of Sleep Disorders defines the disorder as, "a chronic steady pattern comprising one- to two-hour daily delays in sleep onset and wake times in an individual living in society."

In people with this disorder, the person's body essentially insists that the day is longer than 24 hours. This tends to not allow socially accepted sleeping patterns, and makes it difficult for the sufferer to sleep at "normal" times. Most cases that have been reported in the medical literature have occurred in blind patients.

Left untreated, non-24-hour sleep-wake syndrome causes a person's sleep-wake cycle to change every day, the degree determined by how much over 24 hours the cycle lasts. The cycle may go around the clock, eventually returning to "normal" for one or two days before going "off" again. This is known as "Free-running".

People with the disorder often have a hard time "resetting" their internal clocks to socially accepted sleep-wake patterns. They may have an especially hard time adjusting to changes in "regular" sleep-wake cycles, such as vacations, stress, evening activities, time changes like daylight saving time, travel to different time zones, illness, medications (especially stimulants or sedatives), changes in daylight hours in different seasons, and growth spurts, which are typically known to cause fatigue.

Common treatments for non-24-hour sleep-wake syndrome are similar to those for delayed sleep phase syndrome. They include light therapy with a full spectrum lamp giving—usually—10000 lux, chronotherapy, acupuncture, vitamin B12 supplements, and melatonin supplements. It often takes several treatments before any progress is noticed, and for many the treatments may only be marginally effective or not effective at all. In addition, the treatment is not a cure, and the condition can only be managed.

Treatment with melatonin taken 30 minutes to two hours before the desired bedtime may be helpful in righting a pattern "gone awry". Too high a dose of melatonin may have the unintended effect of disturbing the sleep or even causing nightmares, and uncontrollable yawning the next day. Bright light therapy combined with the use of melatonin may be the most effective treatment. The timing of both is tricky and a lot of determination and experimentation is usually necessary.

References

  • Kamgar-Parsi B, Wehr TA, Gillin JC (1983). "Successful treatment of human non-24-hour sleep-wake syndrome". Sleep. 6 (3): 257&ndash, 64.
  • McArthur AJ, Lewy AJ, Sack RL (1996). "Non-24-hour sleep-wake syndrome in a sighted man: circadian rhythm studies and efficacy of melatonin treatment". Sleep. 19 (7): 544&ndash, 53.
  • Uchiyama M; et al. (2000). "Altered phase relation between sleep timing and core body temperature rhythm in delayed sleep phase syndrome and non-24-hour sleep–wake syndrome in humans". Neuroscience Letters. 294 (2): 101&ndash, 104.
  • Uchiyama M, Shibui K, Hayakawa T, Kamei Y, Ebisawa T, Tagaya H, Okawa M, Takahashi K (2002). "Larger phase angle between sleep propensity and melatonin rhythms in sighted humans with non-24-hour sleep-wake syndrome". Sleep. 25 (1): 83&ndash, 88.

See also



Linked-in.jpg