Monoclonal gammopathy of undetermined significance history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief: Omer Kamal, M.D.[3]
Overview
The majority of patients with monoclonal gammopathy of undetermined significance are asymptomatic. Patients with MGUS have no symptoms of myeloma or related malignancy that can be attributable to their monoclonal protein. MGUS commonly arises during evaluation for one of a variety of clinical symptoms and disorders that include peripheral neuropathy, vasculitis, hemolytic anemia, skin rashes, hypercalcemia, and elevated erythrocyte sedimentation rate. It is often an incidental finding on protein electrophoresis.
History and Symptoms
Monoclonal gammopathy of undetermined significance patients are mostly asymptomatic. Discovered often incidentally during diagnosis of other organic diseases, there are usually no history or symptoms at all.[1]
References
- ↑ Therneau TM, Kyle RA, Melton LJ, Larson DR, Benson JT, Colby CL, Dispenzieri A, Kumar S, Katzmann JA, Cerhan JR, Rajkumar SV (November 2012). "Incidence of monoclonal gammopathy of undetermined significance and estimation of duration before first clinical recognition". Mayo Clin. Proc. 87 (11): 1071–9. doi:10.1016/j.mayocp.2012.06.014. PMC 3541934. PMID 22883742.