Liposarcoma natural history
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2]
Overview
The natural history of liposarcoma depends on the histopathological sub-type and location of the tumor. If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the retroperitoneum. Liposarcoma may metastasize to other organs. Lung is the most common location for metastatic disease. Retroperitoneal liposarcomas may affect adjacent organs and structures, that can lead to kidney disease or vascular compression. The prognosis of liposarcoma will depend on the histopathological sub-type. Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this sub-type is better than for other sub-types of liposarcoma. The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.
Natural History, Complications, and Prognosis
Natural History
- The natural history of liposarcoma depends on the histopathological sub-type and location of the tumor.
- If left untreated, liposarcomas may remain silent for a long time, especially if they are located in the retroperitoneum.[1]
- The most common presentation of a liposarcoma located in the extremities is a painless growing mass without additional symptoms.
Complications
- Liposarcoma may metastasize to other organs.
- Lung is the most common location for metastatic disease.
- A myxoid liposarcoma metastasizes more commonly to extrapulmonary locations, such as retroperitoneum, pericardium, chest wall, pleura, and pelvic soft tissue.[1]
- Retroperitoneal liposarcomas may affect adjacent organs and structures, that can lead to kidney disease or vascular compression.[2]
- A case of pancreatitis has been reported due to a dedifferentiated retroperitoneal liposarcoma.[3]
- Other complications can include:
Prognosis
- The prognosis of liposarcoma will depend on the histopathological sub-type.
- Atypical lipomatous neoplasm/well-differentiated liposarcoma has a low metastasis risk, but may recur locally. The prognosis for this sub-type is better than for other sub-types of liposarcoma.[1]
- The pleomorphic liposarcoma has a high metastasis potential and a high recurrence rate. The 5-year disease free survival rate for pleomorphic liposarcoma is 40%.[6]
- The 5-year disease free survival rate for liposarcoma located in the extremities is 74%.[7]
References
- ↑ 1.0 1.1 1.2 Peterson, Jeffrey J.; Kransdorf, Mark J.; Bancroft, Laura W.; O'Connor, Mary I. (2003). "Malignant fatty tumors: classification, clinical course, imaging appearance and treatment". Skeletal Radiology. 32 (9): 493–503. doi:10.1007/s00256-003-0647-8. ISSN 0364-2348.
- ↑ Amit Gupta, Omar Pacha, Rony Skaria, Tam Huynh, Luan Truong & Abdul Abdellatif (2012). "Retroperitoneal sarcoma presenting as acute renal failure, secondary to bilateral renal artery invasion". Clinical nephrology. 78 (2): 164–168. PMID 22790462. Unknown parameter
|month=ignored (help) - ↑ Yusuke Arakawa, Kazuo Yoshioka, Hitomi Kamo, Koichiro Kawano, Takeshi Yamaguchi, Yuko Sumise, Natsu Okitsu, Shizuo Ikeyama, Kojiro Morimoto, Yoshihiro Nakai & Seiki Tashiro (2013). "Huge retroperitoneal dedifferentiated liposarcoma presented as acute pancreatitis: report of a case". The journal of medical investigation : JMI. 60 (1–2): 164–168. PMID 23614927.
- ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter
|month=ignored (help) - ↑ Kazim Duman, Mustafa Girgin & Gokhan Artas (2016). "A case report: Giant intra-abdominal liposarcoma presenting acute renal failure". Annals of medicine and surgery (2012). 12: 90–93. doi:10.1016/j.amsu.2016.09.005. PMID 27942382. Unknown parameter
|month=ignored (help) - ↑ A. M. Oliveira & A. G. Nascimento (2001). "Pleomorphic liposarcoma". Seminars in diagnostic pathology. 18 (4): 274–285. PMID 11757868. Unknown parameter
|month=ignored (help) - ↑ D. B. Pearlstone, P. W. Pisters, R. J. Bold, B. W. Feig, K. K. Hunt, A. W. Yasko, S. Patel, A. Pollack, R. S. Benjamin & R. E. Pollock (1999). "Patterns of recurrence in extremity liposarcoma: implications for staging and follow-up". Cancer. 85 (1): 85–92. PMID 9921978. Unknown parameter
|month=ignored (help)