Islets of Langerhans

Jump to navigation Jump to search

WikiDoc Resources for Islets of Langerhans

Articles

Most recent articles on Islets of Langerhans

Most cited articles on Islets of Langerhans

Review articles on Islets of Langerhans

Articles on Islets of Langerhans in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Islets of Langerhans

Images of Islets of Langerhans

Photos of Islets of Langerhans

Podcasts & MP3s on Islets of Langerhans

Videos on Islets of Langerhans

Evidence Based Medicine

Cochrane Collaboration on Islets of Langerhans

Bandolier on Islets of Langerhans

TRIP on Islets of Langerhans

Clinical Trials

Ongoing Trials on Islets of Langerhans at Clinical Trials.gov

Trial results on Islets of Langerhans

Clinical Trials on Islets of Langerhans at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Islets of Langerhans

NICE Guidance on Islets of Langerhans

NHS PRODIGY Guidance

FDA on Islets of Langerhans

CDC on Islets of Langerhans

Books

Books on Islets of Langerhans

News

Islets of Langerhans in the news

Be alerted to news on Islets of Langerhans

News trends on Islets of Langerhans

Commentary

Blogs on Islets of Langerhans

Definitions

Definitions of Islets of Langerhans

Patient Resources / Community

Patient resources on Islets of Langerhans

Discussion groups on Islets of Langerhans

Patient Handouts on Islets of Langerhans

Directions to Hospitals Treating Islets of Langerhans

Risk calculators and risk factors for Islets of Langerhans

Healthcare Provider Resources

Symptoms of Islets of Langerhans

Causes & Risk Factors for Islets of Langerhans

Diagnostic studies for Islets of Langerhans

Treatment of Islets of Langerhans

Continuing Medical Education (CME)

CME Programs on Islets of Langerhans

International

Islets of Langerhans en Espanol

Islets of Langerhans en Francais

Business

Islets of Langerhans in the Marketplace

Patents on Islets of Langerhans

Experimental / Informatics

List of terms related to Islets of Langerhans

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753


Overview

A porcine islet of Langerhans. The left image is a brightfield image created using hematoxylin stain; nuclei are dark circles and the acinar pancreatic tissue is darker than the islet tissue. The right image is the same section stained by immunofluorescence against insulin, indicating beta cells.
Islets of Langerhans, haemalum-eosin stain.
Section of pancreas of dog. X 250.

The endocrine (i.e., hormone-producing) cells of the pancreas are grouped in the islets of Langerhans. Discovered in 1869 by the German pathological anatomist Paul Langerhans, the islets of Langerhans constitute approximately 1 to 2% of the mass of the pancreas. There are about one million islets in a healthy adult human pancreas, which are interspersed evenly throughout the organ, and their combined weight is 1 to 1.5 grams.

Cell types

Hormones produced in the Islets of Langerhans are secreted directly into the blood flow by (at least) four different types of cells:

Islets can influence each other through paracrine and autocrine communication, and beta-cells are coupled electrically to beta-cells (but not to other cell-types).

Paracrine feedback

The paracrine feedback system of the islets of Langerhans has the following structure:

  • Insulin: Activates beta cells and inhibits alpha cells.
  • Glucagon: Activates alpha which activates beta cells and delta cells.
  • Somatostatin: Inhibits alpha cells and beta cells.

Electrical activity

Electrical activity of pancreatic islets has been studied using patch clamp techniques, and it has turned out that the behavior of cells in intact islets differs significantly from the behaviour of dispersed cells. and is about 30 cm in width

As a treatment for type I diabetes

Since the beta cells in islets of Langerhans are destroyed in type I diabetes, clinicians and researchers are actively pursuing islet transplantation technology as a means of curing this disease.

Transplantation

With the possiblity of restoring beta cells, the Chicago Project headed at University of Illinois at Chicago Medical Center is probing for a way to regenerate beta cells in the islets and have them cultivate on their own within a human pancreas. With that being said, beta cells experience apoptosis early and thus become destroyed within a normal-functioning pancreas. The source of this seems to come from the transfer of Pander, a gene that enters in by attaching to RNA. This process of RNA transportation can be found in the glucose that bombards the beta cells. The genetic encoding found within Pander causes the beta cells to stop during the S phase of mitosis and head straight to apotasis. This ceases much of the reproduction of beta cells within the Islets.

External links

Template:Endocrine pancreas Template:Digestive glands Template:Endocrine system


ar:جزر لانكر cs:Langerhansovy ostrůvky de:Langerhans-Inseln eo:Insuletoj de Langerhans it:Isole di Langerhans he:איי לנגרהנס la:Insulae pancreaticae nl:Eilandjes van Langerhans no:Langerhanske øyer nn:Dei langerhanske øyane sv:Langerhanska öarna


Template:WikiDoc Sources