Intrauterine device

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

An intra-uterine device (intra meaning within, and uterine meaning of the uterus) is a birth control device also known as an IUD or a coil (this colloquialism is based on the coil-shaped design of early IUDs). It is a device placed in the uterus and is the world's most widely used method of reversible birth control,[1] currently used by nearly 160 million women (just over two-thirds of whom are in China where it is the most widely used birth control method, surpassing sterilization).[2] The device has to be fitted inside or removed from the uterus by a doctor or qualified medical practitioner. It remains in place the entire time pregnancy is not desired. Depending on the type, a single IUD is approved for 5 to 10 years use (the copper T 380A is effective for at least 12 years).[3]

Historical Perspective

Presenters at a family planning conference told a tale of Arab traders inserting small stones into the uteruses of their camels to prevent pregnancy. Although the story has been repeated as truth, it has no basis in history and was meant only for entertainment purposes.[4]

Precursors to IUDs were first marketed in 1902. Developed from stem pessaries (where the stem held the pessary in place over the cervix), the 'stem' on these devices actually extended into the uterus itself. Also known as interuterine devices (because they occupied both the vagina and the uterus), they had high rates of infection and were condemned by the medical community.[5]

The first intrauterine device (contained entirely in the uterus) was described in a German publication in 1909, although the author appears to have never marketed his product.[6]

In 1929, Dr. Ernst Gräfenberg of Germany published a report on an IUD made of silk suture. He had found a 3% pregnancy rate among 1,100 women using his ring. In 1930, Dr. Gräfenberg reported a lower pregnancy rate of 1.6% among 600 women using an improved ring wrapped in silver wire. Unbeknownst to Dr. Gräfenberg, the silver wire was contaminated with 26% copper. Copper's role in increasing IUD efficacy would not be recognized until nearly 40 years later.

In 1934, Japanese physician Tenrei Ota developed a variation of the Gräfenberg ring that contained a supportive structure in the center. The addition of this central disc lowered the IUD's expulsion rate. These devices still had high rates of infection, and their use and development was further stifled by World War II politics: contraception was forbidden in both Nazi Germany and Axis-allied Japan. The Western world did not learn of the work by Gräfenberg and Ota until well after the war ended.[6]

The first plastic IUD, the Marguiles Coil or Marguiles Spiral, was introduced in 1958. This device was somewhat large, causing discomfort to a large proportion of women users, and had a hard plastic tail, causing discomfort to their male partners. The Lippes Loop, a slightly smaller device with a monofilament tail, was introduced in 1962 and gained in popularity over the Marguiles device.[5]

The stainless steel single-ring IUD was developed in the 1970s[7] and widely used in China because of low manufacturing costs. The Chinese government banned production of steel IUDs in 1993 due to high failure rates (up to 10% per year).[8][9]

Dr Howard Tatum, in the USA, conceived the plastic T-shaped IUD in 1968. Shortly thereafter Dr Jaime Zipper, in Chile, introduced the idea of adding copper to the devices to improve their contraceptive effectiveness.[5][10] It was found that copper-containing devices could be made in smaller sizes without compromising effectiveness, resulting in fewer side effects such as pain and bleeding.[9] T-shaped devices had lower rates of expulsion due to their greater similarity to the shape of the uterus.[6]

The poorly designed Dalkon Shield plastic IUD (which had a multifilament tail) was manufactured by the A. H. Robins Company and sold by Robins in the United States for three and a half years from January 1971 through June 1974, before sales were suspended by Robins on June 28, 1974 at the request of the FDA because of safety concerns following reports of 110 septic spontaneous abortions in women with the Dalkon Shield in place, seven of whom had died.[11][12] Robins stopped international sales of the Dalkon Shield in April 1975.[13]

Second-generation copper-T IUDs were also introduced in the 1970s. These devices had higher surface areas of copper, and for the first time consistently achieved effectiveness rates of greater than 99%. Worldwide today, with the exception of the new GyneFix, this is the only type of IUD available.[14]

Types of IUDs

Photo of a common IUD (Paragard T 380A)
Photo of a common IUD (Paragard T 380A)

There are two broad categories of intrauterine contraceptive devices: inert and copper-based devices, and hormonally-based devices that work by releasing a progestogen.

In the United States, there are two types of intrauterine contraceptive available; the copper Paragard and the hormonal Mirena. In the U.S., both of these contraceptives are referred to as IUDs.[15]

In the United Kingdom, the term IUD only refers to inert or copper-containing devices; seven types of copper-containing IUDs are available in the UK. There, hormonal uterine contraceptives are considered a different form of contraception than copper IUDs, and they are distinguished with the term IntraUterine System or IUS.[16][17]

Most non-hormonal IUDs have a plastic T-shaped frame that is wound around with pure electrolytic copper wire and/or has copper collars (sleeves). Paragard's T 380a is 32 mm (1.26") in the horizontal direction (top of the T), and 36 mm (1.42") in the vertical direction (leg of the T). In some IUDs, such as the Nova T 380, the pure copper wire has a silver core which has been shown to prevent breaking of the wire.[16][18] The arms of the frame hold the IUD in place near the top of the uterus. The GyneFix does not have a T-shape, but rather is a loop that holds several copper tubes. The GyneFix is held in place by a suture to the fundus of the uterus. All copper-containing IUDs have a number as part of their name. This is the surface area of copper (in square millimeters) the IUD provides.

Effectiveness and Mechanism of Contraception

All second-generation copper-T IUDs have failure rates of less than 1% per year, and cumulative 10-year failure rates of 2-6%.[9] A large World Health Organization trial reported a cumulative 12-year failure rate of 2.2% for the T 380A (ParaGard) (an average failure rate of 0.18% per year over 12 years), equivalent to a cumulative 10-year failure rate of 1.8% following tubal ligation.[3] The frameless GyneFix also has a failure rate of less than 1% per year.[19] Worldwide, older IUD models with lower effectiveness rates are no longer produced.[14]

The presence of a device in the uterus prompts the release of leukocytes and prostaglandins by the endometrium. These substances are hostile to both sperm and eggs; the presence of copper increases this spermicidal effect.[20][21]

Some barrier contraceptives protect against STDs. Hormonal contraceptives reduce the risk of developing pelvic inflammatory disease (PID), a serious complication of certain STDs. IUDs, by contrast, do not protect against STDs or PID.[22]

Non-hormonal (copper) IUDs are considered safe to use while breastfeeding.[2]

While the primary mechanism of action of the IUD is spermicidal/ovicidal, post-fertilization mechanisms are believed by some Christian pro-life physicians to contribute significantly to their effectiveness.[23][24] Because many pro-life individuals and organizations define fertilization as the beginning of pregnancy, this possible secondary mechanism of action has led some pro-life individuals and organizations to label the IUD an abortifacient.

Contraindications

The WHO Medical Eligibility Criteria for Contraceptive Use and RCOG Faculty of Family Planning & Reproductive Health Care (FFPRHC) UK Medical Eligibility Criteria for Contraceptive Use list the following as conditions where insertion of a copper IUD is not usually recommended (category 3) or conditions where a copper IUD should not be inserted (category 4):[25][26]

Category 3

Conditions where the theoretical or proven risks usually outweigh the advantages of inserting a copper IUD:

Category 4

Conditions which represent an unacceptable health risk if a copper IUD is inserted:

Some concern has been expressed that women with metal sensitivities to copper or nickel may experience adverse reactions from an IUD. The metal used in IUDs is 99.99% copper, with one study finding a maximum nickel content of 0.001%. Because nickel has a relatively high sensitizing potential, a few researchers suggested even this tiny amount might be problematic. A few case reports have attributed eczematous dermatitis and urticaria in a handful of users of copper-releasing IUDs to systemic copper or nickel allergic contact dermatitis. However, the daily metal absorption from an IUD is only a fraction of the normal daily absorption from food, and many dermatologists are skeptical that the symptoms described in the case reports were actually caused by metal sensitivity.[27][28][29]

While nulliparous women (women who have never given birth) are somewhat more likely to have side effects, this is not a contraindication for IUD use.

Some doctors prefer to insert the IUD during menstruation to verify that the woman is not pregnant at the time of insertion. However, IUDs may safely be inserted at any time during the menstrual cycle as long as it is reasonably certain the woman is not pregnant.[30] Insertion may be more comfortable if done midcycle, when the cervix is naturally dilated.[31]

Side Effects and Complications

Insertion of the IUD may introduce bacteria into the uterus. The insertion process carries a small, transient increased risk of pelvic inflammatory disease in the first 20 days following insertion.[22] It is very important that the provider use proper infection-prevention techniques during insertion.[32] Antibiotics should be given before insertion to women at high risk for endocarditis (inflammation of the membrane lining the heart), but should not be used routinely.[33]

During the placement appointment, the cervix is dilated in order to sound (measure) the uterus and insert the IUD. Cervix dilation is uncomfortable and, for some women, painful. Doctors often advise women to take painkillers before the procedure to reduce discomfort, and some will use a local anaesthetic.

After IUD insertion, menstrual periods are often heavier, more painful, or both - especially for the first few months after they are inserted. On average, menstrual blood loss increases by 20–50% after insertion of a copper-T IUD; increased menstrual discomfort is the most common medical reason for IUD removal.[34]

Complications include expulsion and uterine perforation. Uterine perforation is generally caused by an inexperienced provider and is very rare. Expulsion is more common in younger women, women who have not had children, and when an IUD is inserted immediately after childbirth or abortion. Women should check the string of the IUD at least once per menstrual cycle to verify that it is still in place.

The string(s) may be felt by some men during intercourse. If this is problematic, the provider may cut the strings even with the cervix, so they cannot be felt. Shortening the strings does prevent the woman from checking for expulsion, however.

The risk of ectopic pregnancy to a woman using an IUD is lower than the risk of ectopic pregnancy to a woman using no form of birth control. However, of pregnancies that do occur during IUD use, a higher than expected percentage (3–4%) are ectopic.[35]

Although the pregnancy rate during IUD use is very low (less than 1% per year), it is not a 100% effective method of birth control. If pregnancy does occur, presence of the IUD increases the risk of miscarriage, particularly during the second trimester. It also increases the risk of premature delivery. These increased risks end if the IUD is removed after pregnancy is discovered. Although the Dalkon Shield IUD was associated with septic abortions (infections associated with miscarriage), other brands of IUD are not. IUDs are also not associated with birth defects or other pregnancy complications.[36]

Use as Emergency Contraception

Intrauterine devices can be used as emergency contraception to prevent pregnancy up to 5 days after unprotected sexual intercourse, or sexual intercourse during which the primary contraception is believed to have failed (e.g. a condom was used, but it broke). Insertion of a copper-T IUD as emergency contraception is more than 99% effective, making it more effective than emergency contraceptive pills (ECP or 'morning-after pill').

Popularity

The IUD is the world's most widely used method of reversible birth control,[1] currently used by nearly 160 million women (just over two-thirds of whom are in China where it is the most widely used birth control method, surpassing sterilization).[2] Usage in many countries has been measured by surveys of married women of reproductive age. In this population, IUD use ranges from 5% in Belgium, to 18% in Scandinavia, 30% in Russia and China, and 40% in Kazakhstan.[37]

In the U.S., the ParaGard T 380A was approved by the FDA in 1984 and became available for use in 1988. It is still the only copper IUD approved for use in the U.S., and was used by 1.3% of women of reproductive age in a 2002 U.S. survey.[38] A wider variety of IUDs is available outside of the U.S. In the U.K., for example, seven brands are available: Flexi-T 300, Multi-Safe 375, Multi-Load Cu 375, Neo-Safe T380, Nova T 380, T-Safe 380A, and GyneFix - also called FlexiGard 330 or CuFix PP330.[16]

Hormonal Uterine Devices

Main article: IntraUterine System

Hormonal uterine devices do not increase bleeding as inert and copper-containing IUDs do. Rather, they reduce menstrual bleeding or prevent menstruation altogether, and can be used as a treatment for menorrhagia (heavy periods).

Although use of IntraUterine Systems results in much lower systemic progestogen levels than other very-low-dose progestogen-only hormonal contraceptives, they might possibly have some of the same side effects.

Progestasert was the first hormonal uterine device, developed in 1976[39] and manufactured until 2001.[40] It released progesterone, was replaced annually, and had a failure rate of 2% per year.[41]

As of 2007, the LNG-20 IUS - marketed as Mirena by Bayer - is the only IntraUterine System available. First introduced in 1990, it releases levonorgestrel (a progestogen) and may be used for five years.

A lower-dose T-shaped IntraUterine System named Femilis is being developed by Contrel, a Belgian company. Contrel also manufactures the FibroPlant-LNG, a frameless IUS. FibroPlant is anchored to the fundus of the uterus as the GyneFix IUD is. Although a number of trials have shown positive results, FibroPlant is not yet commercially available.[42]

Related Chapters

References

  1. ↑ 1.0 1.1 "What are the most widely used contraceptive methods across the world?". Births / Birth control. Institut national d'études démographiques (INED). 2006. Retrieved 2006-11-16.
  2. ↑ 2.0 2.1 World Health Organization (2002). "The intrauterine device (IUD)-worth singing about". Progress in Reproductive Health Research (60): 1–8.
  3. ↑ 3.0 3.1 World Health Organization (1997). "Long-term reversible contraception. Twelve years of experience with the TCu380A and TCu220C". Contraception. 56 (6): 341–52. PMID 9494767.
  4. ↑ "A History of Birth Control Methods". Planned Parenthood. June 2002. Retrieved 2007-10-14., which cites:
    Thomas, Patricia (1988-03-14). "Contraceptives". Medical World News. 29 (5): 48.
  5. ↑ 5.0 5.1 5.2 Lynch, Catherine M. "History of the IUD". Contraception Online. Baylor College of Medicine. Retrieved 2006-07-09.
  6. ↑ 6.0 6.1 6.2 "Evolution and Revolution: The Past, Present, and Future of Contraception". Contraception Online (Baylor College of Medicine). 10 (6). 2000. Unknown parameter |month= ignored (help)
  7. ↑ Bradley, Jeff (August 1998). "Ultrasound Interactive Case Study: Ring IUD". OBGYN.net. Retrieved 2006-07-09. (Has pictures of various IUD designs.)
  8. ↑ Kaufman, J. (1993 May-Jun). "The cost of IUD failure in China". Studies In Family Planning. 24 (3): 194–6. PMID 8351700. Check date values in: |year= (help)
  9. ↑ 9.0 9.1 9.2 IUDs—An Update. Chapter 1: Background.
  10. ↑ Van Kets, H.E. (1997). "Importance of intrauterine contraception". Contraception Today, Proceedings of the 4th Congress of the European Society of Contraception. The Parthenon Publishing Group. pp. 112–116. Retrieved 2006-07-09. Unknown parameter |coauthors= ignored (help) (Has pictures of many IUD designs, both historic and modern.)
  11. ↑ Sivin I (1993). "Another look at the Dalkon Shield: meta-analysis underscores its problems". Contraception. 48 (1): 1–12. PMID 8403900.
  12. ↑ Mintz, Morton (1986). "A Crime Against Women. A. H. Robins and the Dalkon Shield". Multinational Monitor. 7 (1). Unknown parameter |month= ignored (help)
  13. ↑ Salem R (2006). "New Attention to the IUD: Expanding Women's Contraceptive Options To Meet Their Needs". Popul Rep B (7). Unknown parameter |month= ignored (help)
  14. ↑ 14.0 14.1 IUDs—An Update. Chapter 1: Background.
  15. ↑ Treiman K, Liskin L, Kols A, Rinehart W (1995). "IUDs—an update" (PDF). Popul Rep B (6): 1–35. PMID 8724322. Retrieved 2006-01-01.
  16. ↑ 16.0 16.1 16.2 "Contraceptive coils (IUDs)". NetDoctor.co.uk. 2006. Retrieved 2006-07-05.
  17. ↑ French, R (2004). "Hormonally impregnated intrauterine systems (IUSs) versus other forms of reversible contraceptives as effective methods of preventing pregnancy". Cochrane Database of Systematic Reviews (3). PMID 15266453. Unknown parameter |coauthors= ignored (help)
  18. ↑ Schering (2003). "Nova T380 Patient information leaflet (PIL)". Retrieved 2007-04-27. Unknown parameter |month= ignored (help)
  19. ↑ O'Brien, PA (January 25, 2005). "Frameless versus classical intrauterine device for contraception". Cochrane Database of Systematic Reviews (1). PMID. Unknown parameter |coauthors= ignored (help)
  20. ↑ "Mechanisms of the Contraceptive Action of Hormonal Methods and Intrauterine Devices (IUDs)". Family Health International. 2006. Retrieved 2006-07-05.
  21. ↑ Keller, Sarah (Winter 1996, Vol. 16, No. 2). "IUDs Block Fertilization". Network. Family Health International. Retrieved 2006-07-05. Check date values in: |year= (help)
  22. ↑ 22.0 22.1 Farley TM, Rosenberg MJ, Rowe PJ, Chen JH, Meirik O (1992). "Intrauterine devices and pelvic inflammatory disease: an international perspective". Lancet. 339 (8796): 785–8. PMID 1347812.
    Grimes DA (2000). "Intrauterine device and upper-genital-tract infection". Lancet. 356 (9234): 1013–9. PMID 11041414.
    Mishell Jr., Daniel R. (2004). "Contraception". In in Strauss III, Jerome F.; Barbieri, Robert L. (eds.). Yen and Jaffe's Reproductive Endocrinology (5th ed. ed.). Philadelphia: Elsevier Saunders. pp. pp. 899–938. ISBN 0-7216-9546-9.
    Grimes, David A. (2004). "Intrauterine Devices (IUDs)". In in Hatcher, Robert A.; Trussell, James; Stewart, Felicia H.; Nelson, Anita L.; Cates Jr., Willard; Guest, Felicia; Kowal, Deborah (eds.). Contraceptive Technology (18th rev. ed. ed.). New York: Ardent Media. pp. pp. 495–530. ISBN 0-9664902-5-8.
    Speroff, Leon; Darney, Philip D. (2005). "Intauterine Contraception: The IUD". A Clinical Guide for Contraception (4th ed. ed.). Philadelphia: Lippincott Williams & Wilkins. pp. pp. 221–257. ISBN 0-7817-6488-2.
    Hall, Janet E. (2005). "Infertility and Fertility Control". In in Kasper Dennis L.; Braunwald, Eugene; Fauci, Anthony S.; Hauser, Stephen L.; Longo, Dan L.; Jameson, J. Larry (eds.). Harrison's Principles of Internal Medicine (16th ed. ed.). New York: McGraw-Hill. pp. pp. 279-83. ISBN 0-07-139140-1.
    Soper, David E.; Mead, Philip B. (2005). "Infections of the Female Pelvis". In in Mandell, Gerald L.; Bennett, John E.; Dolin, Raphael (eds.). Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases (6th ed. ed.). Philadelphia: Elsevier Chuchill Livingston. pp. pp. 1372–81. ISBN 0-443-06643-4.
    Glasier, Anna (2006). "Contraception". In in DeGroot, Leslie J.; Jameson, J. Larry (eds.). Endocrinology (5th ed. ed.). Philadelphia: Elsevier Saunders. pp. pp. 2993–3003. ISBN 0-7216-0376-9.Stubblefield, Phillip G.; Carr-Ellis, Sacheen; Kapp, Nathalie (2007). "Family Planning". In in Berek, Jonathan A. (ed.). Berek & Novak's Gynecology (14th ed. ed.). Philadelphia: Lippincott Williams & Wilkins. pp. pp. 247–311. ISBN 0-7817-6805-5.
  23. ↑ Stanford J, Mikolajczyk R (2002). "Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects". Am J Obstet Gynecol. 187 (6): 1699–708. PMID 12501086.Smart Y, Fraser I, Clancy R, Roberts T, Cripps A (1982). "Early pregnancy factor as a monitor for fertilization in women wearing intrauterine devices". Fertil Steril. 37 (2): 201–4. PMID 6174375.
  24. ↑ Mikolajczyk, Rafael; Stanford, Joseph (2004). "Arguments against contraception--do they make sense to the general public? Importance of ethics, religion and "natural morality" in choice of family planning methods". In Fehring, Richard J,; Notare, Theresa (eds.). Integrating faith and science through natural family planning. Milwaukee: Marquette University Press. pp. pp. 229-32. ISBN 0874620112.
  25. ↑ WHO (2004). "Intrauterine devices (IUDs)". Medical Eligibility Criteria for Contraceptive Use (3rd ed. ed.). Geneva: Reproductive Health and Research, WHO. ISBN 92-4-156266-8.
  26. ↑ FFPRHC (2006). "The UK Medical Eligibility Criteria for Contraceptive Use (2005/2006)" (PDF). Retrieved 2007-01-11.
  27. ↑ Jouppila P, Niinimäki A, Mikkonen M (1979). "Copper allergy and copper IUD". Contraception. 19 (6): 631–7. PMID 487812.
  28. ↑ Frentz G, Teilum D (1980). "Cutaneous eruptions and intrauterine contraceptive copper device". Acta Derm Venereol. 60 (1): 69–71. PMID 6153839.
  29. ↑ Wohrl S, Hemmer W, Focke M, Gotz M, Jarisch R (2001). "Copper allergy revisited". J Am Acad Dermatol. 45 (6): 863–70. PMID 11712031.
  30. ↑ IUDs-An Update. Chapter 3: Insertion.
  31. ↑ "Understanding IUDs". Planned Parenthood Federation of America. July 2005. Retrieved 2006-07-22.
  32. ↑ IUDs—An Update. Sidebar: Infection Prevention for IUD Insertion and Removal.
  33. ↑ IUDs—An Update. Sidebar: Procedures for Providing IUDs.
  34. ↑ IUDs-An Update. Chapter 2.5: Bleeding and Pain.
  35. ↑ IUDs-An Update. Chapter 2.9:Ectopic Pregnancies.
  36. ↑ IUDs-An Update. Chapter 2.8: Intrauterine Pregnancy.
  37. ↑ IUDs—An Update. Worldwide Use - Developed Countries. Table 2: Worldwide Use of IUDs.
  38. ↑ Chandra, A (2005). "Fertility, Family Planning, and Reproductive Health of U.S. Women: Data From the 2002 National Survey of Family Growth" (PDF). Vital Health Stat. National Center for Health Statistics. 23 (25). Retrieved 2007-05-20. Unknown parameter |coauthors= ignored (help) See Table 56.
  39. ↑ IUDs—An Update. Chapter 2: Types of IUDs.
  40. ↑ Smith (pseudonym), Sydney (Saturday, March 8, 2003). "Contraceptive Concerns". medpundit: Commentary on medical news by a practicing physician. Retrieved 2006-07-16. Check date values in: |date= (help)
  41. ↑ "Birth Control Options: The Progestasert Intrauterine Device (IUD)". Wyoming Health Council. 2004. Retrieved 2006-07-16.
  42. ↑ "New Contraceptive Choices". Population Reports, INFO Project, Center for Communication Programs. The Johns Hopkins School of Public Health. M (19). April 2005. Retrieved 2006-07-14. Chapter 9: Intrauterine Devices.

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