Essential thrombocytosis other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis.[1] On bone marrow biopsy, essential thrombocytosis is characterized by bone marrow hypercellularity with clusters of megakaryocytes that stain positive for iron, increased reticulin, and no collagen fibrosis.

Bone marrow biopsy findings

  • Bone marrow biopsy is an important test and needed to make a diagnosis of essential thrombocytosis.[1]
  • On bone marrow biopsy, essential thrombocytosis is characterized by:
    • Increased cellularity
    • Hyperplasia and clustering of megakaryocytes
    • Bone marrow stains positive for iron
    • Bone marrow reticulin may be increased with no collagen fibrosis

References

  1. 1.0 1.1 Sanchez S, Ewton A (2006). "Essential thrombocythemia: a review of diagnostic and pathologic features". Arch Pathol Lab Med. 130 (8): 1144–50. doi:10.1043/1543-2165(2006)130[1144:ET]2.0.CO;2. PMID 16879015.


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