Argatroban
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| Argatroban
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| Systematic (IUPAC) name | |
| (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2- [[(3R)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl] sulfonylamino]pentanoyl]-4-methyl-piperidine-2- carboxylic acid | |
| Identifiers | |
| CAS number | |
| ATC code | B01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C23H36N6O5S |
| Mol. mass | 508.635 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 100% (intravenous) |
| Protein binding | 54% |
| Metabolism | hepatic |
| Half life | 39 and 51 minutes |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
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| Legal status | |
| Routes | intravenous |
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Evidence Based Medicine | |
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Ongoing Trials on Argatroban at Clinical Trials.gov Clinical Trials on Argatroban at Google
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US National Guidelines Clearinghouse on Argatroban
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Patient resources on Argatroban Discussion groups on Argatroban Patient Handouts on Argatroban Directions to Hospitals Treating Argatroban Risk calculators and risk factors for Argatroban
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753
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Argatroban is an anticoagulant that is a small molecule direct thrombin inhibitor. In 2000, argatroban was licensed by the Food and Drug Administration (FDA) for prophylaxis or treatment of thrombosis in patients with heparin-induced thrombocytopenia. In 2002, it was approved for use during percutaneous coronary interventions in patients who have or at risk for developing HIT.
Argatroban is given intravenously. Argatroban is metabolized in the liver and has a half life of about 50 minutes. It is monitored by PTT. Because of its hepatic metabolism, it may be used in patients with renal dysfunction. (This is in contrast to lepirudin, a direct thrombin inhibitor that is primarily renally cleared).
It is manufactured by GlaxoSmithKline.
Reference
- Di Nisio M, Middeldorp S, Buller HR. Direct thrombin inhibitors. N Engl J Med 2005;353:1028-40. PMID 16148288.
External links
WikiDoc Research Resources for Argatroban | |
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| Articles on Argatroban | Most recent articles on Argatroban • Most cited articles on Argatroban • Review articles on Argatroban • Articles on Argatroban in N Eng J Med, Lancet, BMJ |
| Media (Slides, Video, Images, MP3) on Argatroban | Powerpoint slides on Argatroban • Images of Argatroban • Photos of Argatroban • Podcasts & MP3s on Argatroban • Videos on Argatroban |
| Evidence Based Medicine Regarding Argatroban | Cochrane Collaboration on Argatroban • Bandolier on Argatroban • TRIP on Argatroban |
| Cost Effectiveness of Argatroban | Cost Effectiveness of Argatroban |
| Clinical Trials Involving Argatroban | Ongoing Trials on Argatroban at Clinical Trials.gov • Trial results on Argatroban • Clinical Trials on Argatroban at Google |
| Guidelines / Policies / Government Resources (FDA/CDC) Regarding Argatroban | US National Guidelines Clearinghouse on Argatroban • NICE Guidance on Argatroban • NHS PRODIGY Guidance • FDA on Argatroban • CDC on Argatroban |
| Textbook Information on Argatroban | Books and Textbook Information on Argatroban |
| Pharmacology Resources on Argatroban | Dosing of Argatroban • Drug interactions with Argatroban • Side effects of Argatroban • Allergic reactions to Argatroban • Overdose information on Argatroban • Carcinogenicity information on Argatroban • Argatroban in pregnancy • Pharmacokinetics of Argatroban • |
| Genetics, Pharmacogenomics, and Proteinomics of Argatroban | Genetics of Argatroban • Pharmacogenomics of Argatroban • Proteomics of Argatroban |
| Newstories on Argatroban | Argatroban in the news • Be alerted to news on Argatroban • News trends on Argatroban |
| Commentary on Argatroban | Blogs on Argatroban |
| Patient Resources on Argatroban | Patient resources on Argatroban • Discussion groups on Argatroban • Patient Handouts on Argatroban • Directions to Hospitals Treating Argatroban • Risk calculators and risk factors for Argatroban |
| Healthcare Provider Resources on Argatroban | Symptoms of Argatroban • Causes & Risk Factors for Argatroban • Diagnostic studies for Argatroban • Treatment of Argatroban |
| Continuing Medical Education (CME) Programs on Argatroban | CME Programs on Argatroban |
| International Resources on Argatroban | Argatroban en Espanol • Argatroban en Francais |
| Business Resources on Argatroban | Argatroban in the Marketplace • Patents on Argatroban |
| Informatics Resources on Argatroban | List of terms related to Argatroban |
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Acknowledgement and Attribution Regarding Sources of Content
Some of the initial content on this page may be incorporated in part from copyleft sources in the public domain including wikis such as Wikipedia and AskDrWiki. Drug information for patients came from the The National Library of Medicine. Infectious disease information may have come from the Centers for Disease Control (CDC). Differential Diagnoses are drawn from clinicians as well as an amalgamation of 3 sources: 1.The Disease Database; 2. Kahan, Scott, Smith, Ellen G. In A Page: Signs and Symptoms. Malden, Massachusetts: Blackwell Publishing, 2004:3; 3. Sailer, Christian, Wasner, Susanne. Differential Diagnosis Pocket. Hermosa Beach, CA: Borm Bruckmeir Publishing LLC, 2002:7 .
