Zinc finger and BTB domain-containing protein 16: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Zinc finger and BTB domain-containing protein 16''' is a [[protein]] that in humans is encoded by the ''ZBTB16'' [[gene]].
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| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ZBTB16_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1buo.
| PDB = {{PDB2|1buo}}, {{PDB2|1cs3}}
| Name = Zinc finger and BTB domain containing 16
| HGNCid = 12930
| Symbol = ZBTB16
| AltSymbols =; PLZF; ZNF145
| OMIM = 176797
| ECnumber = 
| Homologene = 21214
| MGIid = 103222
| GeneAtlas_image1 = PBB_GE_ZBTB16_205883_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016566 |text = specific transcriptional repressor activity}} {{GNF_GO|id=GO:0042803 |text = protein homodimerization activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016607 |text = nuclear speck}} {{GNF_GO|id=GO:0017053 |text = transcriptional repressor complex}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001823 |text = mesonephros development}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0009880 |text = embryonic pattern specification}} {{GNF_GO|id=GO:0009952 |text = anterior/posterior pattern formation}} {{GNF_GO|id=GO:0030099 |text = myeloid cell differentiation}} {{GNF_GO|id=GO:0035110 |text = leg morphogenesis}} {{GNF_GO|id=GO:0035116 |text = embryonic hindlimb morphogenesis}} {{GNF_GO|id=GO:0035136 |text = forelimb morphogenesis}} {{GNF_GO|id=GO:0043065 |text = positive regulation of apoptosis}} {{GNF_GO|id=GO:0045638 |text = negative regulation of myeloid cell differentiation}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0048133 |text = male germ-line stem cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7704
    | Hs_Ensembl = ENSG00000109906
    | Hs_RefseqProtein = NP_001018011
    | Hs_RefseqmRNA = NM_001018011
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 113435525
    | Hs_GenLoc_end = 113626562
    | Hs_Uniprot = Q05516
    | Mm_EntrezGene = 235320
    | Mm_Ensembl = ENSMUSG00000066687
    | Mm_RefseqmRNA = NM_001033324
    | Mm_RefseqProtein = NP_001028496
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 48406264
    | Mm_GenLoc_end = 48587864
    | Mm_Uniprot =
  }}
}}
'''Zinc finger and BTB domain containing 16''', also known as '''ZBTB16''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a [[zinc finger]] [[transcription factor]] that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in [[cell cycle]] progression, and interacts with a [[histone deacetylase]]. Specific instances of aberrant gene rearrangement at this locus have been associated with [[acute promyelocytic leukemia]] (APL)<ref>{{cite journal | vauthors = Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A | title = Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia | journal = The EMBO Journal | volume = 12 | issue = 3 | pages = 1161–7 | year = 1993 | pmid = 8384553 | pmc = 413318 }}</ref> and physiological roles have been identified in mouse [[Natural Killer T cell]]s<ref>{{cite journal | vauthors = Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, Kim HJ, Im JS, Pandolfi PP, Sant'Angelo DB | title = The BTB-zinc finger transcriptional regulator, PLZF, controls the development of iNKT cell effector functions | journal = Nature Immunology | volume = 9 | issue = 9 | pages = 1055–64 | year = 2008 | pmid = 18660811 | pmc = 2662733 | doi = 10.1038/ni.1641 | display-authors = 8 }}</ref><ref>{{cite journal | vauthors = Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A | title = The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage | journal = Immunity | volume = 29 | issue = 3 | pages = 391–403 | year = 2008 | pmid = 18703361 | pmc = 2613001 | doi = 10.1016/j.immuni.2008.07.011 }}</ref> and [[γδ T cells|gamma-delta T cells]].<ref>{{cite journal | vauthors = Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H | title = TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 106 | issue = 30 | pages = 12453–8 | year = 2009 | pmid = 19617548 | pmc = 2718370 | doi = 10.1073/pnas.0903895106 }}</ref> Alternate transcriptional splice variants have been characterized in human.<ref>{{cite journal | vauthors = Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, Tong JH, Gu BW, Yu M, Liu JX, Licht J, Waxman S, Zelent A, Chen E, Chen SJ | title = Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11422–7 | year = 1999 | pmid = 10500192 | pmc = 18049 | doi = 10.1073/pnas.96.20.11422 | url = http://www.pnas.org/content/96/20/11422.full | display-authors = 8 }}</ref><ref name="entrez">{{cite web |title=ZBTB16 zinc finger and BTB domain containing 16 |url=https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7704 |work=[[Entrez]] |date=4 October 2009 |accessdate=10 October 2009}}</ref>
{{PBB_Summary
| section_title =
| summary_text = This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: ZBTB16 zinc finger and BTB domain containing 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7704| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
Zinc finger and BTB domain-containing protein 16 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[Angiotensin II receptor type 1]],<ref name = pmid14657020>{{cite journal | vauthors = Senbonmatsu T, Saito T, Landon EJ, Watanabe O, Price E, Roberts RL, Imboden H, Fitzgerald TG, Gaffney FA, Inagami T | title = A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy | journal = EMBO J. | volume = 22 | issue = 24 | pages = 6471–82 | pmid = 14657020 | pmc = 291832 | doi = 10.1093/emboj/cdg637 | display-authors = 8 }}</ref>
* [[BCL6]],<ref name = pmid11175338>{{cite journal | vauthors = Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH | title = Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF | journal = Oncogene | volume = 19 | issue = 54 | pages = 6240–50 | pmid = 11175338 | doi = 10.1038/sj.onc.1203976 }}</ref>
* [[BMI1]],<ref name = pmid12408802>{{cite journal | vauthors = Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP | title = Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling | journal = Dev. Cell | volume = 3 | issue = 4 | pages = 499–510 | pmid = 12408802 | doi =  10.1016/s1534-5807(02)00289-7}}</ref>
* [[Calcitriol receptor]],<ref name = pmid11719366/><ref name = pmid12460926>{{cite journal | vauthors = Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M | title = AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor | journal = Cancer Res. | volume = 62 | issue = 23 | pages = 7050–8 | pmid = 12460926 | doi =  | display-authors = 8 }}</ref>
* [[FHL2]],<ref name = pmid12145280>{{cite journal | vauthors = McLoughlin P, Ehler E, Carlile G, Licht JD, Schäfer BW | title = The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein | journal = J. Biol. Chem. | volume = 277 | issue = 40 | pages = 37045–53 | pmid = 12145280 | doi = 10.1074/jbc.M203336200 }}</ref>
* [[GATA1]],<ref name = pmid12242665>{{cite journal | vauthors = Labbaye C, Quaranta MT, Pagliuca A, Militi S, Licht JD, Testa U, Peschle C | title = PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein | journal = Oncogene | volume = 21 | issue = 43 | pages = 6669–79 | pmid = 12242665 | doi = 10.1038/sj.onc.1205884 }}</ref>
* [[GATA2]],<ref name = pmid11964310>{{cite journal | vauthors = Tsuzuki S, Enver T | title = Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein | journal = Blood | volume = 99 | issue = 9 | pages = 3404–10 | pmid = 11964310 | doi =  10.1182/blood.v99.9.3404}}</ref>
* [[HDAC1]],<ref name = pmid15467736/><ref name = pmid9627120/><ref name = pmid9765306/>
* [[HDAC4]],<ref name = pmid15467736/><ref name = pmid11929873/>
* [[HDAC6]],<ref name = pmid15467736/>
* [[Heparin-binding EGF-like growth factor]],<ref name = pmid14597771>{{cite journal | vauthors = Nanba D, Mammoto A, Hashimoto K, Higashiyama S | title = Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF | journal = J. Cell Biol. | volume = 163 | issue = 3 | pages = 489–502 | pmid = 14597771 | pmc = 2173632 | doi = 10.1083/jcb.200303017 }}</ref><ref name = pmid15219838>{{cite journal | vauthors = Nanba D, Toki F, Higashiyama S | title = Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF | journal = Biochem. Biophys. Res. Commun. | volume = 320 | issue = 2 | pages = 376–82 | pmid = 15219838 | doi = 10.1016/j.bbrc.2004.05.176 }}</ref>
* [[Histone deacetylase 5]],<ref name = pmid15467736>{{cite journal | vauthors = Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A | title = HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF | journal = Oncogene | volume = 23 | issue = 54 | pages = 8777–84 | pmid = 15467736 | doi = 10.1038/sj.onc.1208128 }}</ref><ref name = pmid11929873>{{cite journal | vauthors = Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S | title = Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor | journal = J. Biol. Chem. | volume = 277 | issue = 24 | pages = 22045–52 | pmid = 11929873 | doi = 10.1074/jbc.M201736200 }}</ref>
* [[Nuclear receptor co-repressor 2]],<ref name = pmid9765306>{{cite journal | vauthors = Wong CW, Privalsky ML | title = Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6 | journal = J. Biol. Chem. | volume = 273 | issue = 42 | pages = 27695–702 | pmid = 9765306 | doi =  10.1074/jbc.273.42.27695}}</ref><ref name = pmid14982881>{{cite journal | vauthors = Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD | title = The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT | journal = Blood | volume = 103 | issue = 12 | pages = 4650–8 | pmid = 14982881 | doi = 10.1182/blood-2003-08-2759 }}</ref><ref name = pmid9256429>{{cite journal | vauthors = Hong SH, David G, Wong CW, Dejean A, Privalsky ML | title = SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 17 | pages = 9028–33 | pmid = 9256429 | pmc = 23013 | doi =  10.1073/pnas.94.17.9028}}</ref>
* [[Promyelocytic leukemia protein]]<ref name = pmid9294197>{{cite journal | vauthors = Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, Chen S, Chen Z, Tan CC, Licht J, Waxman S, de Thé H, Zelent A | title = Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 19 | pages = 10255–60 | pmid = 9294197 | pmc = 23349 | doi =  10.1073/pnas.94.19.10255| display-authors = 8 }}</ref>
* [[RUNX1T1]],<ref name = pmid10688654>{{cite journal | vauthors = Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD | title = The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 6 | pages = 2075–86 | pmid = 10688654 | pmc = 110824 | doi =  10.1128/mcb.20.6.2075-2086.2000}}</ref><ref name = pmid11090081>{{cite journal | vauthors = Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD | title = AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein | journal = Blood | volume = 96 | issue = 12 | pages = 3939–47 | pmid = 11090081 | doi =  }}</ref>
* [[Retinoic acid receptor alpha]],<ref name = pmid14521715>{{cite journal | vauthors = Martin PJ, Delmotte MH, Formstecher P, Lefebvre P | title = PLZF is a negative regulator of retinoic acid receptor transcriptional activity | journal = Nucl. Recept. | volume = 1 | issue = 1 | pages = 6 | pmid = 14521715 | pmc = 212040 | doi = 10.1186/1478-1336-1-6 }}</ref>
* [[SIN3A]],<ref name = pmid11719366>{{cite journal | vauthors = Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP | title = The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor | journal = Blood | volume = 98 | issue = 12 | pages = 3290–300 | pmid = 11719366 | doi =  10.1182/blood.v98.12.3290}}</ref><ref name = pmid9627120/><ref name = pmid9765306/>
* [[SIN3B]],<ref name = pmid9627120>{{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}</ref>  and
* [[ZBTB32]].<ref name = pmid10572087>{{cite journal | vauthors = Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD | title = A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF | journal = Blood | volume = 94 | issue = 11 | pages = 3737–47 | pmid = 10572087 | doi =  | display-authors = 8 }}</ref>
{{Div col end}}
 
== See also ==
* [[Zbtb7]]
* [[Zbtb7]]


==References==
== References ==
{{reflist|2}}
{{Reflist|2}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A | title = Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia | journal = The EMBO Journal | volume = 12 | issue = 3 | pages = 1161–7 | year = 1993 | pmid = 8384553 | pmc = 413318 }}
| citations =
* {{cite journal | vauthors = Chen SJ, Zelent A, Tong JH, Yu HQ, Wang ZY, Derré J, Berger R, Waxman S, Chen Z | title = Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia | journal = The Journal of Clinical Investigation | volume = 91 | issue = 5 | pages = 2260–7 | year = 1993 | pmid = 8387545 | pmc = 288229 | doi = 10.1172/JCI116453 }}
*{{cite journal | author=Chen Z, Brand NJ, Chen A, ''et al.'' |title=Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia. |journal=EMBO J. |volume=12 |issue= 3 |pages= 1161-7 |year= 1993 |pmid= 8384553 |doi= }}
* {{cite journal | vauthors = Reid A, Gould A, Brand N, Cook M, Strutt P, Li J, Licht J, Waxman S, Krumlauf R, Zelent A | title = Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors | journal = Blood | volume = 86 | issue = 12 | pages = 4544–52 | year = 1995 | pmid = 8541544 | display-authors = 8 }}
*{{cite journal | author=Chen SJ, Zelent A, Tong JH, ''et al.'' |title=Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia. |journal=J. Clin. Invest. |volume=91 |issue= 5 |pages= 2260-7 |year= 1993 |pmid= 8387545 |doi= }}
* {{cite journal | vauthors = Dong S, Zhu J, Reid A, Strutt P, Guidez F, Zhong HJ, Wang ZY, Licht J, Waxman S, Chomienne C, Chen Z, Zelent A, Chen SJ | title = Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 8 | pages = 3624–9 | year = 1996 | pmid = 8622986 | pmc = 39661 | doi = 10.1073/pnas.93.8.3624 | display-authors = 8 }}
*{{cite journal | author=Reid A, Gould A, Brand N, ''et al.'' |title=Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors. |journal=Blood |volume=86 |issue= 12 |pages= 4544-52 |year= 1996 |pmid= 8541544 |doi= }}
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | year = 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Dong S, Zhu J, Reid A, ''et al.'' |title=Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3624-9 |year= 1996 |pmid= 8622986 |doi= }}
* {{cite journal | vauthors = Hong SH, David G, Wong CW, Dejean A, Privalsky ML | title = SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor α (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 17 | pages = 9028–33 | year = 1997 | pmid = 9256429 | pmc = 23013 | doi = 10.1073/pnas.94.17.9028 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, Chen S, Chen Z, Tan CC, Licht J, Waxman S, de Thé H, Zelent A | title = Leukemia-associated retinoic acid receptor α fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 19 | pages = 10255–60 | year = 1997 | pmid = 9294197 | pmc = 23349 | doi = 10.1073/pnas.94.19.10255 | display-authors = 8 }}
*{{cite journal | author=Hong SH, David G, Wong CW, ''et al.'' |title=SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 17 |pages= 9028-33 |year= 1997 |pmid= 9256429 |doi= }}
* {{cite journal | vauthors = Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM | title = Role of the histone deacetylase complex in acute promyelocytic leukaemia | journal = Nature | volume = 391 | issue = 6669 | pages = 811–4 | year = 1998 | pmid = 9486654 | doi = 10.1038/35895 }}
*{{cite journal | author=Koken MH, Reid A, Quignon F, ''et al.'' |title=Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 19 |pages= 10255-60 |year= 1997 |pmid= 9294197 |doi= }}
* {{cite journal | vauthors = Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A | title = Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia | journal = Blood | volume = 91 | issue = 8 | pages = 2634–42 | year = 1998 | pmid = 9531570 }}
*{{cite journal  | author=Lin RJ, Nagy L, Inoue S, ''et al.'' |title=Role of the histone deacetylase complex in acute promyelocytic leukaemia. |journal=Nature |volume=391 |issue= 6669 |pages= 811-4 |year= 1998 |pmid= 9486654 |doi= 10.1038/35895 }}
* {{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | year = 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}
*{{cite journal | author=Guidez F, Ivins S, Zhu J, ''et al.'' |title=Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. |journal=Blood |volume=91 |issue= 8 |pages= 2634-42 |year= 1998 |pmid= 9531570 |doi=  }}
* {{cite journal | vauthors = Ahmad KF, Engel CK, Privé GG | title = Crystal structure of the BTB domain from PLZF | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 21 | pages = 12123–8 | year = 1998 | pmid = 9770450 | pmc = 22795 | doi = 10.1073/pnas.95.21.12123 }}
*{{cite journal | author=David G, Alland L, Hong SH, ''et al.'' |title=Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. |journal=Oncogene |volume=16 |issue= 19 |pages= 2549-56 |year= 1998 |pmid= 9627120 |doi= 10.1038/sj.onc.1202043 }}
* {{cite journal | vauthors = van Schothorst EM, Prins DE, Baysal BE, Beekman M, Licht JD, Waxman S, Zelent A, Cornelisse CJ, van Ommen GJ, Richard CW, Devilee P | title = Genomic structure of the human PLZF gene | journal = Gene | volume = 236 | issue = 1 | pages = 21–4 | year = 1999 | pmid = 10433962 | doi = 10.1016/S0378-1119(99)00277-2 | display-authors = 8 }}
*{{cite journal | author=Ahmad KF, Engel CK, Privé GG |title=Crystal structure of the BTB domain from PLZF. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12123-8 |year= 1998 |pmid= 9770450 |doi= }}
* {{cite journal | vauthors = Ball HJ, Melnick A, Shaknovich R, Kohanski RA, Licht JD | title = The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase | journal = Nucleic Acids Research | volume = 27 | issue = 20 | pages = 4106–13 | year = 1999 | pmid = 10497277 | pmc = 148680 | doi = 10.1093/nar/27.20.4106 }}
*{{cite journal | author=van Schothorst EM, Prins DE, Baysal BE, ''et al.'' |title=Genomic structure of the human PLZF gene. |journal=Gene |volume=236 |issue= 1 |pages= 21-4 |year= 1999 |pmid= 10433962 |doi= }}
* {{cite journal | vauthors = Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, Tong JH, Gu BW, Yu M, Liu JX, Licht J, Waxman S, Zelent A, Chen E, Chen SJ | title = Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 20 | pages = 11422–7 | year = 1999 | pmid = 10500192 | pmc = 18049 | doi = 10.1073/pnas.96.20.11422 | display-authors = 8 }}
*{{cite journal | author=Ball HJ, Melnick A, Shaknovich R, ''et al.'' |title=The promyelocytic leukemia zinc finger (PLZF) protein binds DNA in a high molecular weight complex associated with cdc2 kinase. |journal=Nucleic Acids Res. |volume=27 |issue= 20 |pages= 4106-13 |year= 1999 |pmid= 10497277 |doi= }}
* {{cite journal | vauthors = Li X, Peng H, Schultz DC, Lopez-Guisa JM, Rauscher FJ, Marmorstein R | title = Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein | journal = Cancer Research | volume = 59 | issue = 20 | pages = 5275–82 | year = 1999 | pmid = 10537309 }}
*{{cite journal | author=Zhang T, Xiong H, Kan LX, ''et al.'' |title=Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11422-7 |year= 1999 |pmid= 10500192 |doi= }}
* {{cite journal | vauthors = Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, Owen G, Zelent A, Licht JD | title = A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF | journal = Blood | volume = 94 | issue = 11 | pages = 3737–47 | year = 1999 | pmid = 10572087 | display-authors = 8 }}
*{{cite journal | author=Li X, Peng H, Schultz DC, ''et al.'' |title=Structure-function studies of the BTB/POZ transcriptional repression domain from the promyelocytic leukemia zinc finger oncoprotein. |journal=Cancer Res. |volume=59 |issue= 20 |pages= 5275-82 |year= 1999 |pmid= 10537309 |doi=  }}
* {{cite journal | vauthors = Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD | title = The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein | journal = Molecular and Cellular Biology | volume = 20 | issue = 6 | pages = 2075–86 | year = 2000 | pmid = 10688654 | pmc = 110824 | doi = 10.1128/MCB.20.6.2075-2086.2000 }}
*{{cite journal | author=Hoatlin ME, Zhi Y, Ball H, ''et al.'' |title=A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. |journal=Blood |volume=94 |issue= 11 |pages= 3737-47 |year= 1999 |pmid= 10572087 |doi= }}
* {{cite journal | vauthors = Hyman J, Chen H, Di Fiore PP, De Camilli P, Brunger AT | title = Epsin 1 Undergoes Nucleocytosolic Shuttling and Its Eps15 Interactor Nh2-Terminal Homology (Enth) Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger Protein (Plzf) | journal = The Journal of Cell Biology | volume = 149 | issue = 3 | pages = 537–46 | year = 2000 | pmid = 10791968 | pmc = 2174850 | doi = 10.1083/jcb.149.3.537 }}
*{{cite journal | author=Melnick AM, Westendorf JJ, Polinger A, ''et al.'' |title=The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2075-86 |year= 2000 |pmid= 10688654 |doi= }}
* {{cite journal | vauthors = Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD | title = AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein | journal = Blood | volume = 96 | issue = 12 | pages = 3939–47 | year = 2000 | pmid = 11090081 }}
*{{cite journal | author=Hyman J, Chen H, Di Fiore PP, ''et al.'' |title=Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 537-46 |year= 2000 |pmid= 10791968 |doi= }}
* {{cite journal | vauthors = Beez S, Demmer P, Puccetti E | title = Targeting the Acute Promyelocytic Leukemia-Associated Fusion Proteins PML/RARα and PLZF/RARα with Interfering Peptides | journal = PLoS ONE | volume = 7 | issue = 11 | pages = e48636 | year = 2012 | pmid = 23152790 | pmc = 3494703 | doi = 10.1371/journal.pone.0048636 }}
*{{cite journal | author=Melnick A, Carlile GW, McConnell MJ, ''et al.'' |title=AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein. |journal=Blood |volume=96 |issue= 12 |pages= 3939-47 |year= 2001 |pmid= 11090081 |doi=  }}
* {{cite journal | vauthors = He LZ, Bhaumik M, Tribioli C, Rego EM, Ivins S, Zelent A, Pandolfi PP | title = Two critical hits for promyelocytic leukemia | journal = Molecular Cell | volume = 6 | issue = 5 | pages = 1131–41 | year = 2000 | pmid = 11106752 | doi = 10.1016/S1097-2765(00)00111-8 }}
*{{cite journal | author=He LZ, Bhaumik M, Tribioli C, ''et al.'' |title=Two critical hits for promyelocytic leukemia. |journal=Mol. Cell |volume=6 |issue= 5 |pages= 1131-41 |year= 2002 |pmid= 11106752 |doi= }}
{{Refend}}
}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|ZBTB16+protein,+human}}
* {{MeshName|ZBTB16+protein,+human}}


{{NLM content}}
{{PDB Gallery|geneid=7704}}
{{Transcription factors|g2}}


{{protein-stub}}
{{DEFAULTSORT:Zinc Finger And Btb Domain-Containing Protein 16}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}

Latest revision as of 02:20, 19 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene.

Function

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)[1] and physiological roles have been identified in mouse Natural Killer T cells[2][3] and gamma-delta T cells.[4] Alternate transcriptional splice variants have been characterized in human.[5][6]

Interactions

Zinc finger and BTB domain-containing protein 16 has been shown to interact with:

See also

References

  1. ↑ Chen Z, Brand NJ, Chen A, Chen SJ, Tong JH, Wang ZY, Waxman S, Zelent A (1993). "Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia". The EMBO Journal. 12 (3): 1161–7. PMC 413318. PMID 8384553.
  2. ↑ Kovalovsky D, Uche OU, Eladad S, Hobbs RM, Yi W, Alonzo E, Chua K, Eidson M, et al. (2008). "The BTB-zinc finger transcriptional regulator, PLZF, controls the development of iNKT cell effector functions". Nature Immunology. 9 (9): 1055–64. doi:10.1038/ni.1641. PMC 2662733. PMID 18660811.
  3. ↑ Savage AK, Constantinides MG, Han J, Picard D, Martin E, Li B, Lantz O, Bendelac A (2008). "The transcription factor PLZF (Zbtb16) directs the effector program of the NKT cell lineage". Immunity. 29 (3): 391–403. doi:10.1016/j.immuni.2008.07.011. PMC 2613001. PMID 18703361.
  4. ↑ Kreslavsky T, Savage AK, Hobbs R, Gounari F, Bronson R, Pereira P, Pandolfi PP, Bendelac A, von Boehmer H (2009). "TCR-inducible PLZF transcription factor required for innate phenotype of a subset of γδ T cells with restricted TCR diversity". Proceedings of the National Academy of Sciences of the United States of America. 106 (30): 12453–8. doi:10.1073/pnas.0903895106. PMC 2718370. PMID 19617548.
  5. ↑ Zhang T, Xiong H, Kan LX, Zhang CK, Jiao XF, Fu G, Zhang QH, Lu L, et al. (1999). "Genomic sequence, structural organization, molecular evolution, and aberrant rearrangement of promyelocytic leukemia zinc finger gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (20): 11422–7. doi:10.1073/pnas.96.20.11422. PMC 18049. PMID 10500192.
  6. ↑ "ZBTB16 zinc finger and BTB domain containing 16". Entrez. 4 October 2009. Retrieved 10 October 2009.
  7. ↑ Senbonmatsu T, Saito T, Landon EJ, Watanabe O, Price E, Roberts RL, Imboden H, Fitzgerald TG, et al. "A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy". EMBO J. 22 (24): 6471–82. doi:10.1093/emboj/cdg637. PMC 291832. PMID 14657020.
  8. ↑ Dhordain P, Albagli O, Honore N, Guidez F, Lantoine D, Schmid M, The HD, Zelent A, Koken MH. "Colocalization and heteromerization between the two human oncogene POZ/zinc finger proteins, LAZ3 (BCL6) and PLZF". Oncogene. 19 (54): 6240–50. doi:10.1038/sj.onc.1203976. PMID 11175338.
  9. ↑ Barna M, Merghoub T, Costoya JA, Ruggero D, Branford M, Bergia A, Samori B, Pandolfi PP. "Plzf mediates transcriptional repression of HoxD gene expression through chromatin remodeling". Dev. Cell. 3 (4): 499–510. doi:10.1016/s1534-5807(02)00289-7. PMID 12408802.
  10. ↑ 10.0 10.1 Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD, Freedman LP. "The acute promyelocytic leukemia-associated protein, promyelocytic leukemia zinc finger, regulates 1,25-dihydroxyvitamin D(3)-induced monocytic differentiation of U937 cells through a physical interaction with vitamin D(3) receptor". Blood. 98 (12): 3290–300. doi:10.1182/blood.v98.12.3290. PMID 11719366.
  11. ↑ Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, et al. "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. PMID 12460926.
  12. ↑ McLoughlin P, Ehler E, Carlile G, Licht JD, Schäfer BW. "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". J. Biol. Chem. 277 (40): 37045–53. doi:10.1074/jbc.M203336200. PMID 12145280.
  13. ↑ Labbaye C, Quaranta MT, Pagliuca A, Militi S, Licht JD, Testa U, Peschle C. "PLZF induces megakaryocytic development, activates Tpo receptor expression and interacts with GATA1 protein". Oncogene. 21 (43): 6669–79. doi:10.1038/sj.onc.1205884. PMID 12242665.
  14. ↑ Tsuzuki S, Enver T. "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein". Blood. 99 (9): 3404–10. doi:10.1182/blood.v99.9.3404. PMID 11964310.
  15. ↑ 15.0 15.1 15.2 15.3 Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, Dejean A, Harel-Bellan A. "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF". Oncogene. 23 (54): 8777–84. doi:10.1038/sj.onc.1208128. PMID 15467736.
  16. ↑ 16.0 16.1 16.2 David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A. "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
  17. ↑ 17.0 17.1 17.2 Wong CW, Privalsky ML. "Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6". J. Biol. Chem. 273 (42): 27695–702. doi:10.1074/jbc.273.42.27695. PMID 9765306.
  18. ↑ 18.0 18.1 Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S. "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi:10.1074/jbc.M201736200. PMID 11929873.
  19. ↑ Nanba D, Mammoto A, Hashimoto K, Higashiyama S. "Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF". J. Cell Biol. 163 (3): 489–502. doi:10.1083/jcb.200303017. PMC 2173632. PMID 14597771.
  20. ↑ Nanba D, Toki F, Higashiyama S. "Roles of charged amino acid residues in the cytoplasmic domain of proHB-EGF". Biochem. Biophys. Res. Commun. 320 (2): 376–82. doi:10.1016/j.bbrc.2004.05.176. PMID 15219838.
  21. ↑ Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD. "The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT". Blood. 103 (12): 4650–8. doi:10.1182/blood-2003-08-2759. PMID 14982881.
  22. ↑ Hong SH, David G, Wong CW, Dejean A, Privalsky ML. "SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARalpha) and PLZF-RARalpha oncoproteins associated with acute promyelocytic leukemia". Proc. Natl. Acad. Sci. U.S.A. 94 (17): 9028–33. doi:10.1073/pnas.94.17.9028. PMC 23013. PMID 9256429.
  23. ↑ Koken MH, Reid A, Quignon F, Chelbi-Alix MK, Davies JM, Kabarowski JH, Zhu J, Dong S, et al. "Leukemia-associated retinoic acid receptor alpha fusion partners, PML and PLZF, heterodimerize and colocalize to nuclear bodies". Proc. Natl. Acad. Sci. U.S.A. 94 (19): 10255–60. doi:10.1073/pnas.94.19.10255. PMC 23349. PMID 9294197.
  24. ↑ Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD. "The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein". Mol. Cell. Biol. 20 (6): 2075–86. doi:10.1128/mcb.20.6.2075-2086.2000. PMC 110824. PMID 10688654.
  25. ↑ Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD. "AML-1/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein". Blood. 96 (12): 3939–47. PMID 11090081.
  26. ↑ Martin PJ, Delmotte MH, Formstecher P, Lefebvre P. "PLZF is a negative regulator of retinoic acid receptor transcriptional activity". Nucl. Recept. 1 (1): 6. doi:10.1186/1478-1336-1-6. PMC 212040. PMID 14521715.
  27. ↑ Hoatlin ME, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, Arai S, Hawe N, et al. "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF". Blood. 94 (11): 3737–47. PMID 10572087.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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