Wilms' tumor causes: Difference between revisions

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{{CMG}}
{{Wilms' tumor}}
{{Wilms' tumor}}
{{CMG}}; {{AE}} {{SC}}{{SSW}}


==Overview==
==Overview==
The casue of wilms' tumor is genetic mutations.
Wilms' tumor may be caused by either [[Genetics|genetic]] [[Mutation|mutations]] or [[Chromosome|chromosomal]] alterations.
 
==Causes==
==Causes==
Wilms tumor is the most common form of childhood kidney cancer. The exact cause of this tumor in most children is unknown.
* [[Genetic]] mutations: <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq </ref>
===Genetic factors===
** Wilms tumor 1 gene ([[WT1]])
 
** WT2<ref name="pmid9441738">{{cite journal |vauthors=Crider-Miller SJ, Reid LH, Higgins MJ, Nowak NJ, Shows TB, Futreal PA, Weissman BE |title=Novel transcribed sequences within the BWS/WT2 region in 11p15.5: tissue-specific expression correlates with cancer type |journal=Genomics |volume=46 |issue=3 |pages=355–63 |date=December 1997 |pmid=9441738 |doi=10.1006/geno.1997.5061 |url=}}</ref>
** WTX<ref name="pmid17204608">{{cite journal |vauthors=Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA |title=An X chromosome gene, WTX, is commonly inactivated in Wilms tumor |journal=Science |volume=315 |issue=5812 |pages=642–5 |date=February 2007 |pmid=17204608 |doi=10.1126/science.1137509 |url=}}</ref>


* Other genes and chromosomal alterations:
** 1q<ref name="pmid1850292">{{cite journal |vauthors=Truong HT, Pratt EA, Ho C |title=Interaction of the membrane-bound D-lactate dehydrogenase of Escherichia coli with phospholipid vesicles and reconstitution of activity using a spin-labeled fatty acid as an electron acceptor: a magnetic resonance and biochemical study |journal=Biochemistry |volume=30 |issue=16 |pages=3893–8 |date=April 1991 |pmid=1850292 |doi= |url=}}</ref>
** 16q and 1p<ref name="pmid8162576">{{cite journal |vauthors=Grundy PE, Telzerow PE, Breslow N, Moksness J, Huff V, Paterson MC |title=Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome |journal=Cancer Res. |volume=54 |issue=9 |pages=2331–3 |date=May 1994 |pmid=8162576 |doi= |url=}}</ref>
** CACNA1E<ref name="pmid17189400">{{cite journal |vauthors=Natrajan R, Little SE, Reis-Filho JS, Hing L, Messahel B, Grundy PE, Dome JS, Schneider T, Vujanic GM, Pritchard-Jones K, Jones C |title=Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors |journal=Clin. Cancer Res. |volume=12 |issue=24 |pages=7284–93 |date=December 2006 |pmid=17189400 |doi=10.1158/1078-0432.CCR-06-1567 |url=}}</ref>
** 7p21
** SKCG-1
** TP53 (tumor suppressor gene)
** FBXW7
** PTCH1
** DICER1
** MYCN
==References==
==References==
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{{Reflist|2}}
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[[Category:Urology]]
[[Category:Urology]]
[[Category:Pediatrics]]
[[Category:Pediatrics]]
[[Category:Oncology]]
[[Category:Hematology]]
[[Category:Hematology]]

Latest revision as of 19:53, 18 June 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]Sargun Singh Walia M.B.B.S.[3]

Overview

Wilms' tumor may be caused by either genetic mutations or chromosomal alterations.

Causes

  • Other genes and chromosomal alterations:
    • 1q[4]
    • 16q and 1p[5]
    • CACNA1E[6]
    • 7p21
    • SKCG-1
    • TP53 (tumor suppressor gene)
    • FBXW7
    • PTCH1
    • DICER1
    • MYCN

References

  1. National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/publications/pdq
  2. Crider-Miller SJ, Reid LH, Higgins MJ, Nowak NJ, Shows TB, Futreal PA, Weissman BE (December 1997). "Novel transcribed sequences within the BWS/WT2 region in 11p15.5: tissue-specific expression correlates with cancer type". Genomics. 46 (3): 355–63. doi:10.1006/geno.1997.5061. PMID 9441738.
  3. Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO, Chin L, Iafrate AJ, Bell DW, Haber DA (February 2007). "An X chromosome gene, WTX, is commonly inactivated in Wilms tumor". Science. 315 (5812): 642–5. doi:10.1126/science.1137509. PMID 17204608.
  4. Truong HT, Pratt EA, Ho C (April 1991). "Interaction of the membrane-bound D-lactate dehydrogenase of Escherichia coli with phospholipid vesicles and reconstitution of activity using a spin-labeled fatty acid as an electron acceptor: a magnetic resonance and biochemical study". Biochemistry. 30 (16): 3893–8. PMID 1850292.
  5. Grundy PE, Telzerow PE, Breslow N, Moksness J, Huff V, Paterson MC (May 1994). "Loss of heterozygosity for chromosomes 16q and 1p in Wilms' tumors predicts an adverse outcome". Cancer Res. 54 (9): 2331–3. PMID 8162576.
  6. Natrajan R, Little SE, Reis-Filho JS, Hing L, Messahel B, Grundy PE, Dome JS, Schneider T, Vujanic GM, Pritchard-Jones K, Jones C (December 2006). "Amplification and overexpression of CACNA1E correlates with relapse in favorable histology Wilms' tumors". Clin. Cancer Res. 12 (24): 7284–93. doi:10.1158/1078-0432.CCR-06-1567. PMID 17189400.

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