Wilms' tumor other diagnostic studies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sargun Singh Walia M.B.B.S.[2]
Overview
Other diagnostic studies for Wilms tumor include PET scan and histology of biopsy samples taken.
Other Diagnostic Studies
Other diagnostic studies for Wilms tumor include:
- PET scan[1]
- 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT.
- Wilms tumor is 18F-FDG avid, and 18F-FDG-PET-CT imaging adds clinically applicable information to conventional imaging.
- This may be particularly helpful in patients with bilateral disease or those receiving preoperative chemotherapy.
- 18F-FDG-PET-CT highlights FDG-avid areas in the tumor and metastases.
- This corresponds to histologically confirmed active disease.
- Biopsy
- Histology of the biopsy sample taken during surgery is the gold standard for the diagnosis of Wilms tumor.[2][3]
- The following result of histology is confirmatory of Wilms tumor:[4]
- Triphasic histology comprising -
- Anaplastic changes
- Most of the tumors of the kidney have a favorable histology(90%).
- If anaplastic changes(3-7%) are found then the outcome is poor.[5]
- The surgical examination and biopsy must be performed when:
- If a case of Wilms tumor is suspected in North America, then nephrectomy is done immediately.
- Contralateral kidney is also explored to check for disease and lymph node biopsies done.
- Transcutaneous biopsy samples are almost never taken to prevent:
- Tumor spill - If this occurs then whole abdomen radiotherapy has to be done.
- The surgical examination and biopsy must be performed when:
References
- ↑ Hildebrandt MG, Gerke O, Baun C, Falch K, Hansen JA, Farahani ZA, Petersen H, Larsen LB, Duvnjak S, Buskevica I, Bektas S, Søe K, Jylling AM, Ewertz M, Alavi A, Høilund-Carlsen PF (June 2016). "[18F]Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET)/Computed Tomography (CT) in Suspected Recurrent Breast Cancer: A Prospective Comparative Study of Dual-Time-Point FDG-PET/CT, Contrast-Enhanced CT, and Bone Scintigraphy". J. Clin. Oncol. 34 (16): 1889–97. doi:10.1200/JCO.2015.63.5185. PMID 27001573.
- ↑ Tentzeris M, Fritz G (May 1973). "[Suction and irrigation drainage in the therapy of acute and chronic osteomyelitis]". Zentralbl Chir (in German). 98 (21): 771–4. PMID 4728859.
- ↑ Stefanowicz J, Sierota D, Balcerska A, Stoba C (2004). "[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report]". Med Wieku Rozwoj (in Polish). 8 (2 Pt 1): 197–200. PMID 15738594.
- ↑ Hansz J, Prazmowska-Owczarek B, Nowicka G (1979). "[Granulocyte adherence in advanced Hodgkin's disease and its dependence on antiproliferative drugs used]". Acta Haematol Pol (in Polish). 10 (1): 7–12. PMID 373364.
- ↑ Stefanowicz J, Sierota D, Balcerska A, Stoba C (2004). "[Wilms' tumour of unfavorable histology--results of treatment with the SIOP 93-01 protocol at the Gdańsk centre. Preliminary report]". Med Wieku Rozwoj (in Polish). 8 (2 Pt 1): 197–200. PMID 15738594.
- ↑ https://librepathology.org/wiki/File:Wilms_tumour_-_low_mag.jpg#filelinks
- ↑ https://upload.wikimedia.org/wikipedia/commons/a/a8/Wilms_Tumour.jpg
