Wee1-like protein kinase

WEE1 homolog (S. pombe)
File:PBB Protein WEE1 image.jpg PDB rendering based on 1x8b.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x8b​
Identifiers
Symbols	WEE1 ; DKFZp686I18166; FLJ16446; WEE1hu
External IDs	Template:OMIM5 Template:MGI HomoloGene: 31152
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WEE1 homolog (S. pombe), also known as WEE1, is a human gene.

This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.

Further reading

• Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377.
• Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780.
• Le Rouzic E, Benichou S (2006). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology. 2: 11. doi:10.1186/1742-4690-2-11. PMID 15725353.
• Zhao RY, Elder RT (2005). "Viral infections and cell cycle G2/M regulation". Cell Res. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
• Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): 270–86. PMID 15817944.CS1 maint: Multiple names: authors list (link)
• Li L, Li HS, Pauza CD; et al. (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Res. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Igarashi M, Nagata A, Jinno S; et al. (1991). "Wee1(+)-like gene in human cells". Nature. 353 (6339): 80–3. doi:10.1038/353080a0. PMID 1840647.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Baldin V, Ducommun B (1995). "Subcellular localisation of human wee1 kinase is regulated during the cell cycle". J. Cell. Sci. 108 ( Pt 6): 2425–32. PMID 7673359.
• Watanabe N, Broome M, Hunter T (1995). "Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle". EMBO J. 14 (9): 1878–91. PMID 7743995.CS1 maint: Multiple names: authors list (link)
• McGowan CH, Russell P (1995). "Cell cycle regulation of human WEE1". EMBO J. 14 (10): 2166–75. PMID 7774574.
• Kharbanda S, Yuan ZM, Taneja N; et al. (1994). "p56/p53lyn tyrosine kinase activation in mammalian cells treated with mitomycin C.". Oncogene. 9 (10): 3005–11. PMID 8084605.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Heald R, McLoughlin M, McKeon F (1993). "Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase". Cell. 74 (3): 463–74. PMID 8348613.CS1 maint: Multiple names: authors list (link)
• McGowan CH, Russell P (1993). "Human Wee1 kinase inhibits cell division by phosphorylating p34cdc2 exclusively on Tyr15". EMBO J. 12 (1): 75–85. PMID 8428596.
• Taviaux SA, Demaille JG (1993). "Localization of human cell cycle regulatory genes CDC25C to 5q31 and WEE1 to 11p15.3-11p15.1 by fluorescence in situ hybridization". Genomics. 15 (1): 194–6. doi:10.1006/geno.1993.1032. PMID 8432534.
• Booher RN, Holman PS, Fattaey A (1997). "Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity". J. Biol. Chem. 272 (35): 22300–6. PMID 9268380.CS1 maint: Multiple names: authors list (link)
• Zhou BB, Li H, Yuan J, Kirschner MW (1998). "Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6785–90. PMID 9618490.CS1 maint: Multiple names: authors list (link)
• Taylor WR, DePrimo SE, Agarwal A; et al. (1999). "Mechanisms of G2 arrest in response to overexpression of p53". Mol. Biol. Cell. 10 (11): 3607–22. PMID 10564259.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Jacobs C, Hook KE; et al. (2000). "Binding of 14-3-3beta to the carboxyl terminus of Wee1 increases Wee1 stability, kinase activity, and G2-M cell population". Cell Growth Differ. 11 (4): 211–9. PMID 10775038.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cichutek A, Brueckmann T, Seipel B; et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)". Cytogenet. Cell Genet. 93 (3–4): 277–83. PMID 11528126.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Elder RT, Yu M, Chen M; et al. (2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25". Virology. 287 (2): 359–70. doi:10.1006/viro.2001.1007. PMID 11531413.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)