WNK1

WNK lysine deficient protein kinase 1
File:PBB Protein WNK1 image.jpg PDB rendering based on 1t4h.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1t4h​
Identifiers
Symbols	WNK1 ; KDP; KIAA0344; PHA2C; PRKWNK1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 14253
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE WNK1 211992 at tn.png
File:PBB GE WNK1 211993 at tn.png
File:PBB GE WNK1 211994 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

WNK lysine deficient protein kinase 1, also known as WNK1, is a human gene.

The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]

Further reading

• Hart GW, Haltiwanger RS, Holt GD, Kelly WG (1989). "Nucleoplasmic and cytoplasmic glycoproteins". Ciba Found. Symp. 145: 102–12, discussion 112-8. PMID 2507249.CS1 maint: Multiple names: authors list (link)
• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. PMID 12168954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu BE, Lee BH, Min X; et al. (2005). "WNK1: analysis of protein kinase structure, downstream targets, and potential roles in hypertension". Cell Res. 15 (1): 6–10. doi:10.1038/sj.cr.7290256. PMID 15686619.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Subramanya AR, Yang CL, McCormick JA, Ellison DH (2006). "WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron". Kidney Int. 70 (4): 630–4. doi:10.1038/sj.ki.5001634. PMID 16820787.CS1 maint: Multiple names: authors list (link)
• Huang CL, Kuo E (2007). "Mechanisms of disease: WNK-ing at the mechanism of salt-sensitive hypertension". Nature clinical practice. Nephrology. 3 (11): 623–30. doi:10.1038/ncpneph0638. PMID 17957199.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Nagase T, Ishikawa K, Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. PMID 9205841.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moore TM, Garg R, Johnson C; et al. (2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization". J. Biol. Chem. 275 (6): 4311–22. PMID 10660600.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Disse-Nicodème S, Achard JM, Desitter I; et al. (2000). "A new locus on chromosome 12p13.3 for pseudohypoaldosteronism type II, an autosomal dominant form of hypertension". Am. J. Hum. Genet. 67 (2): 302–10. PMID 10869238.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilson FH, Disse-Nicodème S, Choate KA; et al. (2001). "Human hypertension caused by mutations in WNK kinases". Science. 293 (5532): 1107–12. doi:10.1126/science.1062844. PMID 11498583.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Veríssimo F, Jordan P (2001). "WNK kinases, a novel protein kinase subfamily in multi-cellular organisms". Oncogene. 20 (39): 5562–9. doi:10.1038/sj.onc.1204726. PMID 11571656.
• Xu BE, Min X, Stippec S; et al. (2003). "Regulation of WNK1 by an autoinhibitory domain and autophosphorylation". J. Biol. Chem. 277 (50): 48456–62. doi:10.1074/jbc.M207917200. PMID 12374799.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vitari AC, Deak M, Collins BJ; et al. (2004). "WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate". Biochem. J. 378 (Pt 1): 257–68. doi:10.1042/BJ20031692. PMID 14611643.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Delaloy C, Lu J, Houot AM; et al. (2004). "Multiple promoters in the WNK1 gene: one controls expression of a kidney-specific kinase-defective isoform". Mol. Cell. Biol. 23 (24): 9208–21. PMID 14645531.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu BE, Stippec S, Lenertz L; et al. (2004). "WNK1 activates ERK5 by an MEKK2/3-dependent mechanism". J. Biol. Chem. 279 (9): 7826–31. doi:10.1074/jbc.M313465200. PMID 14681216.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu GK, Wang JT, Yang J; et al. (2005). "Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes". Genomics. 84 (1): 205–10. doi:10.1016/j.ygeno.2004.01.011. PMID 15203218.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Jin J, Smith FD, Stark C; et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)