Valosin-containing protein

Valosin-containing protein
File:PBB Protein VCP image.jpg PDB rendering based on 1e32.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1e32​, 1oz4​, 1r7r​, 1s3s​, 1ypw​, 1yq0​, 1yqi​, 2pjh​
Identifiers
Symbols	VCP ; p97; IBMPFD; MGC131997; MGC148092; MGC8560; TERA
External IDs	Template:OMIM5 Template:MGI HomoloGene: 5168
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE VCP 208649 s at tn.png
File:PBB GE VCP 208648 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Valosin-containing protein, also known as VCP, is a human gene.

Valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. VCP has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation.

Further reading

• Guinto JB, Ritson GP, Taylor JP, Forman MS (2007). "Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy". Acta Neuropathol. 114 (1): 55–61. doi:10.1007/s00401-007-0224-7. PMID 17457594.CS1 maint: Multiple names: authors list (link)
• Dawson SJ, White LA (1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". J. Infect. 24 (3): 317–20. PMID 1602151.
• Rabouille C, Levine TP, Peters JM, Warren G (1995). "An NSF-like ATPase, p97, and NSF mediate cisternal regrowth from mitotic Golgi fragments". Cell. 82 (6): 905–14. PMID 7553851.CS1 maint: Multiple names: authors list (link)
• Pleasure IT, Black MM, Keen JH (1993). "Valosin-containing protein, VCP, is a ubiquitous clathrin-binding protein". Nature. 365 (6445): 459–62. doi:10.1038/365459a0. PMID 8413590.CS1 maint: Multiple names: authors list (link)
• Druck T, Gu Y, Prabhala G; et al. (1996). "Chromosome localization of human genes for clathrin adaptor polypeptides AP2 beta and AP50 and the clathrin-binding protein, VCP". Genomics. 30 (1): 94–7. doi:10.1006/geno.1995.0016. PMID 8595912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Germain-Lee EL, Obie C, Valle D (1997). "NVL: a new member of the AAA family of ATPases localized to the nucleus". Genomics. 44 (1): 22–34. doi:10.1006/geno.1997.4856. PMID 9286697.CS1 maint: Multiple names: authors list (link)
• Hoyle J, Tan KH, Fisher EM (1997). "Mapping the valosin-containing protein (VCP) gene on human chromosome 9 and mouse chromosome 4, and a likely pseudogene on the mouse X chromosome". Mamm. Genome. 8 (10): 778–80. PMID 9321476.CS1 maint: Multiple names: authors list (link)
• Dai RM, Chen E, Longo DL; et al. (1998). "Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha". J. Biol. Chem. 273 (6): 3562–73. PMID 9452483.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Rabouille C, Kondo H, Newman R; et al. (1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro". Cell. 92 (5): 603–10. PMID 9506515.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhang SH, Liu J, Kobayashi R, Tonks NK (1999). "Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1". J. Biol. Chem. 274 (25): 17806–12. PMID 10364224.CS1 maint: Multiple names: authors list (link)
• Zhang H, Wang Q, Kajino K, Greene MI (2000). "VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells". DNA Cell Biol. 19 (5): 253–63. doi:10.1089/10445490050021168. PMID 10855792.CS1 maint: Multiple names: authors list (link)
• Hu RM, Han ZG, Song HD; et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lavoie C, Chevet E, Roy L; et al. (2001). "Tyrosine phosphorylation of p97 regulates transitional endoplasmic reticulum assembly in vitro". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13637–42. doi:10.1073/pnas.240278097. PMID 11087817.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kimonis VE, Kovach MJ, Waggoner B; et al. (2001). "Clinical and molecular studies in a unique family with autosomal dominant limb-girdle muscular dystrophy and Paget disease of bone". Genet. Med. 2 (4): 232–41. PMID 11252708.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Seigneurin-Berny D, Verdel A, Curtet S; et al. (2001). "Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways". Mol. Cell. Biol. 21 (23): 8035–44. doi:10.1128/MCB.21.23.8035-8044.2001. PMID 11689694.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
• Asai T, Tomita Y, Nakatsuka S; et al. (2002). "VCP (p97) regulates NFkappaB signaling pathway, which is important for metastasis of osteosarcoma cell line". Jpn. J. Cancer Res. 93 (3): 296–304. PMID 11927012.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kobayashi T, Tanaka K, Inoue K, Kakizuka A (2003). "Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells". J. Biol. Chem. 277 (49): 47358–65. doi:10.1074/jbc.M207783200. PMID 12351637.CS1 maint: Multiple names: authors list (link)
• Uchiyama K, Jokitalo E, Kano F; et al. (2003). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo". J. Cell Biol. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMID 12473691.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)