USP7

Ubiquitin specific peptidase 7 (herpes virus-associated)
File:PBB Protein USP7 image.jpg PDB rendering based on 1nb8.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1nb8​, 1nbf​, 1yy6​, 1yze​, 2f1w​, 2f1x​, 2f1y​, 2f1z​, 2foj​, 2foo​, 2fop​
Identifiers
Symbols	USP7 ; HAUSP; TEF1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2592
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE USP7 201498 at tn.png
File:PBB GE USP7 201499 s at tn.png
File:PBB GE USP7 222032 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Ubiquitin specific peptidase 7 (herpes virus-associated), also known as USP7, is a human gene.

HAUSP is a direct antagonist of Mdm2 activity and acts by removing ubiquitin molecules specifically from p53 when stimulated by DNA damage. Interestingly, HAUSP can protect p53 from Mdm2-mediated degradation, indicating that it may possess a tumor suppressor function for the immediate stabilization of p53 in response to stress. Another exciting premise of HAUSP function involves the oncogenic stabilization of p53. Oncogenes such as Myc and E1A are thought to activate p53 through a p19 alternative reading frame (p19ARF, also called ARF)-dependent pathway, although some evidence suggests ARF is not essential in this process. An intriguing possibility is that HAUSP provides an alternative pathway for safeguarding the cell against oncogenic insults.

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. PMID 9827704.
• Puente XS, Sánchez LM, Overall CM, López-Otín C (2003). "Human and mouse proteases: a comparative genomic approach". Nat. Rev. Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.CS1 maint: Multiple names: authors list (link)
• Holowaty MN, Frappier L (2005). "HAUSP/USP7 as an Epstein-Barr virus target". Biochem. Soc. Trans. 32 (Pt 5): 731–2. doi:10.1042/BST0320731. PMID 15494000.
• Everett RD, Meredith M, Orr A; et al. (1997). "A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein". EMBO J. 16 (3): 566–77. doi:10.1093/emboj/16.3.566. PMID 9034339.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Everett RD, Meredith M, Orr A; et al. (1997). "A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein". EMBO J. 16 (7): 1519–30. doi:10.1093/emboj/16.7.1519. PMID 9130697.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Robinson PA, Lomonte P, Leek; et al. (1999). "Assignment1 of herpesvirus-associated ubiquitin-specific protease gene HAUSP to human chromosome band 16p13.3 by in situ hybridization". Cytogenet. Cell Genet. 83 (1–2): 100. PMID 9925944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zapata JM, Pawlowski K, Haas E; et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains". J. Biol. Chem. 276 (26): 24242–52. doi:10.1074/jbc.M100354200. PMID 11279055.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li M, Chen D, Shiloh A; et al. (2002). "Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization". Nature. 416 (6881): 648–53. doi:10.1038/nature737. PMID 11923872.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hong S, Kim SJ, Ka S; et al. (2002). "USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product". Mol. Cell. Neurosci. 20 (2): 298–306. PMID 12093161.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu M, Li P, Li M; et al. (2003). "Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde". Cell. 111 (7): 1041–54. PMID 12507430.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Holowaty MN, Sheng Y, Nguyen T; et al. (2004). "Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP". J. Biol. Chem. 278 (48): 47753–61. doi:10.1074/jbc.M307200200. PMID 14506283.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Brajenovic M, Joberty G, Küster B; et al. (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li M, Brooks CL, Kon N, Gu W (2004). "A dynamic role of HAUSP in the p53-Mdm2 pathway". Mol. Cell. 13 (6): 879–86. PMID 15053880.CS1 maint: Multiple names: authors list (link)
• Cummins JM, Rago C, Kohli M; et al. (2004). "Tumour suppression: disruption of HAUSP gene stabilizes p53". Nature. 428 (6982): 1 p following 486. doi:10.1038/nature02501. PMID 15058298.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Canning M, Boutell C, Parkinson J, Everett RD (2004). "A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7". J. Biol. Chem. 279 (37): 38160–8. doi:10.1074/jbc.M402885200. PMID 15247261.CS1 maint: Multiple names: authors list (link)
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Saridakis V, Sheng Y, Sarkari F; et al. (2005). "Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization". Mol. Cell. 18 (1): 25–36. doi:10.1016/j.molcel.2005.02.029. PMID 15808506.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)