UHRF1: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ubiquitin-like, containing PHD and RING finger domains, 1''', also known as '''UHRF1''', is a [[protein]] which in humans is encoded by the ''UHRF1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29128| accessdate = }}</ref><ref name="pmid10646863">{{cite journal | vauthors = Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C | title = ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression | journal = Cancer Research | volume = 60 | issue = 1 | pages = 121–8 | date = Jan 2000 | pmid = 10646863 | doi = | url = http://cancerres.aacrjournals.org/cgi/content/abstract/60/1/121 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_UHRF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2faz.
| PDB = {{PDB2|2faz}}
| Name = Ubiquitin-like, containing PHD and RING finger domains, 1
| HGNCid = 12556
| Symbol = UHRF1
| AltSymbols =; FLJ21925; ICBP90; MGC138707; Np95; RNF106
| OMIM = 607990
| ECnumber = 
| Homologene = 7866
| MGIid = 1338889
| GeneAtlas_image1 = PBB_GE_UHRF1_gnf1h00130_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006464 |text = protein modification process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29128
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_001041666
    | Hs_RefseqmRNA = NM_001048201
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 18140
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_972841
    | Mm_RefseqProtein = XP_977935
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Ubiquitin-like, containing PHD and RING finger domains, 1''', also known as '''UHRF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29128| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of a subfamily of [[RING finger domain|RING-finger]] type [[E3 ubiquitin ligase]]s. The protein binds to hemi-methylated DNA during S-phase and recruits the main DNA methyltransferase gene, [[DNMT1]], to regulate chromatin structure and gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the [[cell cycle]]. It plays a major role in the G1/S transition, and functions in the [[p53]]-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. It was originally identified as a direct regulator of topoisomerase 2a, but this has subsequently been disproven.  Uhrf1 has been extensively studied in vivo using zebrafish.
{{PBB_Summary
 
| section_title =
== Clinical significance ==
| summary_text = This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29128| accessdate = }}</ref>
 
}}
UHRF1 has recently been identified as a novel [[oncogene]] in hepatocellular carcinoma, the primary type of liver cancer.<ref>{{Cite journal | url=http://www.cell.com/cancer-cell/abstract/S1535-6108%2814%2900031-2 | doi=10.1016/j.ccr.2014.01.003| pmid=24486181| pmc=3951208| title=UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma| journal=Cancer Cell| volume=25| issue=2| pages=196–209| year=2014| last1=Mudbhary| first1=Raksha| last2=Hoshida| first2=Yujin| last3=Chernyavskaya| first3=Yelena| last4=Jacob| first4=Vinitha| last5=Villanueva| first5=Augusto| last6=Fiel| first6=M. Isabel| last7=Chen| first7=Xintong| last8=Kojima| first8=Kensuke| last9=Thung| first9=Swan| last10=Bronson| first10=Roderick T.| last11=Lachenmayer| first11=Anja| last12=Revill| first12=Kate| last13=Alsinet| first13=Clara| last14=Sachidanandam| first14=Ravi| last15=Desai| first15=Anal| last16=Senbanerjee| first16=Sucharita| last17=Ukomadu| first17=Chinweike| last18=Llovet| first18=Josep M.| last19=Sadler| first19=Kirsten C.}}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==


==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ku DH, Chang CD, Koniecki J, Cannizzaro LA, Boghosian-Sell L, Alder H, Baserga R | title = A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor | journal = Cell Growth & Differentiation | volume = 2 | issue = 4 | pages = 179–86  | date = Apr 1991 | pmid = 1868030 | doi =  }}
| citations =
* {{cite journal | vauthors = Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M | title = Generation and analysis of 280,000 human expressed sequence tags | journal = Genome Research | volume = 6 | issue = 9 | pages = 807–28 | year = 1997 | date = Sep 1996 | pmid = 8889549 | doi = 10.1101/gr.6.9.807 }}
*{{cite journal | author=Ku DH, Chang CD, Koniecki J, ''et al.'' |title=A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor. |journal=Cell Growth Differ. |volume=2 |issue= 4 |pages= 179-86 |year= 1991 |pmid= 1868030 |doi=  }}
* {{cite journal | vauthors = Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C | title = ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression | journal = Cancer Research | volume = 60 | issue = 1 | pages = 121–8  | date = Jan 2000 | pmid = 10646863 | doi =  }}
*{{cite journal | author=Hillier LD, Lennon G, Becker M, ''et al.'' |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807-28 |year= 1997 |pmid= 8889549 |doi=  }}
* {{cite journal | vauthors = Hopfner R, Mousli M, Garnier JM, Redon R, du Manoir S, Chatton B, Ghyselinck N, Oudet P, Bronner C | title = Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression | journal = Gene | volume = 266 | issue = 1-2 | pages = 15–23  | date = Mar 2001 | pmid = 11290415 | doi = 10.1016/S0378-1119(01)00371-7 }}
*{{cite journal  | author=Hopfner R, Mousli M, Jeltsch JM, ''et al.'' |title=ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 121-8 |year= 2000 |pmid= 10646863 |doi= }}
* {{cite journal | vauthors = Mousli M, Hopfner R, Abbady AQ, Monté D, Jeanblanc M, Oudet P, Louis B, Bronner C | title = ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells | journal = British Journal of Cancer | volume = 89 | issue = 1 | pages = 120–7  | date = Jul 2003 | pmid = 12838312 | pmc = 2394215 | doi = 10.1038/sj.bjc.6601068 }}
*{{cite journal | author=Hopfner R, Mousli M, Garnier JM, ''et al.'' |title=Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression. |journal=Gene |volume=266 |issue= 1-2 |pages= 15-23 |year= 2001 |pmid= 11290415 |doi=  }}
* {{cite journal | vauthors = Citterio E, Papait R, Nicassio F, Vecchi M, Gomiero P, Mantovani R, Di Fiore PP, Bonapace IM | title = Np95 is a histone-binding protein endowed with ubiquitin ligase activity | journal = Molecular and Cellular Biology | volume = 24 | issue = 6 | pages = 2526–35  | date = Mar 2004 | pmid = 14993289 | pmc = 355858 | doi = 10.1128/MCB.24.6.2526-2535.2004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Arima Y, Hirota T, Bronner C, Mousli M, Fujiwara T, Niwa S, Ishikawa H, Saya H | title = Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition | journal = Genes to Cells | volume = 9 | issue = 2 | pages = 131–42  | date = Feb 2004 | pmid = 15009091 | doi = 10.1111/j.1356-9597.2004.00710.x }}
*{{cite journal | author=Mousli M, Hopfner R, Abbady AQ, ''et al.'' |title=ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells. |journal=Br. J. Cancer |volume=89 |issue= 1 |pages= 120-7 |year= 2003 |pmid= 12838312 |doi= 10.1038/sj.bjc.6601068 }}
* {{cite journal | vauthors = Abbady AQ, Bronner C, Trotzier MA, Hopfner R, Bathami K, Muller CD, Jeanblanc M, Mousli M | title = ICBP90 expression is downregulated in apoptosis-induced Jurkat cells | journal = Annals of the New York Academy of Sciences | volume = 1010 | issue = | pages = 300–3 | year = 2004 | date = Dec 2003 | pmid = 15033738 | doi = 10.1196/annals.1299.052 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | year = 2005 | date = Jun 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Citterio E, Papait R, Nicassio F, ''et al.'' |title=Np95 is a histone-binding protein endowed with ubiquitin ligase activity. |journal=Mol. Cell. Biol. |volume=24 |issue= 6 |pages= 2526-35 |year= 2004 |pmid= 14993289 |doi= }}
* {{cite journal | vauthors = Trotzier MA, Bronner C, Bathami K, Mathieu E, Abbady AQ, Jeanblanc M, Muller CD, Rochette-Egly C, Mousli M | title = Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression | journal = Biochemical and Biophysical Research Communications | volume = 319 | issue = 2 | pages = 590–5  | date = Jun 2004 | pmid = 15178447 | doi = 10.1016/j.bbrc.2004.05.028 }}
*{{cite journal | author=Arima Y, Hirota T, Bronner C, ''et al.'' |title=Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition. |journal=Genes Cells |volume=9 |issue= 2 |pages= 131-42 |year= 2004 |pmid= 15009091 |doi= }}
* {{cite journal | vauthors = Unoki M, Nishidate T, Nakamura Y | title = ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain | journal = Oncogene | volume = 23 | issue = 46 | pages = 7601–10  | date = Oct 2004 | pmid = 15361834 | doi = 10.1038/sj.onc.1208053 }}
*{{cite journal | author=Abbady AQ, Bronner C, Trotzier MA, ''et al.'' |title=ICBP90 expression is downregulated in apoptosis-induced Jurkat cells. |journal=Ann. N. Y. Acad. Sci. |volume=1010 |issue= |pages= 300-3 |year= 2004 |pmid= 15033738 |doi= }}
* {{cite journal | vauthors = Abbady AQ, Bronner C, Bathami K, Muller CD, Jeanblanc M, Mathieu E, Klein JP, Candolfi E, Mousli M | title = TCR pathway involves ICBP90 gene down-regulation via E2F binding sites | journal = Biochemical Pharmacology | volume = 70 | issue = 4 | pages = 570–9  | date = Aug 2005 | pmid = 15964557 | doi = 10.1016/j.bcp.2005.05.012 }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
* {{cite journal | vauthors = Jeanblanc M, Mousli M, Hopfner R, Bathami K, Martinet N, Abbady AQ, Siffert JC, Mathieu E, Muller CD, Bronner C | title = The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle | journal = Oncogene | volume = 24 | issue = 49 | pages = 7337–45  | date = Nov 2005 | pmid = 16007129 | doi = 10.1038/sj.onc.1208878 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
* {{cite journal | vauthors = Jenkins Y, Markovtsov V, Lang W, Sharma P, Pearsall D, Warner J, Franci C, Huang B, Huang J, Yam GC, Vistan JP, Pali E, Vialard J, Janicot M, Lorens JB, Payan DG, Hitoshi Y | title = Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth | journal = Molecular Biology of the Cell | volume = 16 | issue = 12 | pages = 5621–9 | year = 2006 | date = Dec 2005 | pmid = 16195352 | pmc = 1289407 | doi = 10.1091/mbc.E05-03-0194 }}
*{{cite journal | author=Trotzier MA, Bronner C, Bathami K, ''et al.'' |title=Phosphorylation of ICBP90 by protein kinase A enhances topoisomerase IIalpha expression. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 2 |pages= 590-5 |year= 2004 |pmid= 15178447 |doi= 10.1016/j.bbrc.2004.05.028 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65  | date = Jan 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Unoki M, Nishidate T, Nakamura Y |title=ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain. |journal=Oncogene |volume=23 |issue= 46 |pages= 7601-10 |year= 2004 |pmid= 15361834 |doi= 10.1038/sj.onc.1208053 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92  | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Abbady AQ, Bronner C, Bathami K, ''et al.'' |title=TCR pathway involves ICBP90 gene down-regulation via E2F binding sites. |journal=Biochem. Pharmacol. |volume=70 |issue= 4 |pages= 570-9 |year= 2005 |pmid= 15964557 |doi= 10.1016/j.bcp.2005.05.012 }}
* {{cite journal | vauthors = Muto M, Fujimori A, Nenoi M, Daino K, Matsuda Y, Kuroiwa A, Kubo E, Kanari Y, Utsuno M, Tsuji H, Ukai H, Mita K, Takahagi M, Tatsumi K | title = Isolation and Characterization of a Novel Human Radiosusceptibility Gene, NP95 | journal = Radiation Research | volume = 166 | issue = 5 | pages = 723–33 | date = Nov 2006 | pmid = 17067204 | doi = 10.1667/RR0459.1 }}
*{{cite journal | author=Jeanblanc M, Mousli M, Hopfner R, ''et al.'' |title=The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycle. |journal=Oncogene |volume=24 |issue= 49 |pages= 7337-45 |year= 2005 |pmid= 16007129 |doi= 10.1038/sj.onc.1208878 }}
*{{cite journal | author=Jenkins Y, Markovtsov V, Lang W, ''et al.'' |title=Critical role of the ubiquitin ligase activity of UHRF1, a nuclear RING finger protein, in tumor cell growth. |journal=Mol. Biol. Cell |volume=16 |issue= 12 |pages= 5621-9 |year= 2006 |pmid= 16195352 |doi= 10.1091/mbc.E05-03-0194 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Muto M, Fujimori A, Nenoi M, ''et al.'' |title=Isolation and Characterization of a Novel Human Radiosusceptibility Gene, NP95. |journal=Radiat. Res. |volume=166 |issue= 5 |pages= 723-33 |year= 2006 |pmid= 17067204 |doi= 10.1667/RR0459.1 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=29128}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 10:41, 5 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene.[1][2]

Function

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to hemi-methylated DNA during S-phase and recruits the main DNA methyltransferase gene, DNMT1, to regulate chromatin structure and gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. It was originally identified as a direct regulator of topoisomerase 2a, but this has subsequently been disproven. Uhrf1 has been extensively studied in vivo using zebrafish.

Clinical significance

UHRF1 has recently been identified as a novel oncogene in hepatocellular carcinoma, the primary type of liver cancer.[3]

References

  1. ↑ "Entrez Gene: UHRF1 ubiquitin-like, containing PHD and RING finger domains, 1".
  2. ↑ Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C (Jan 2000). "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression". Cancer Research. 60 (1): 121–8. PMID 10646863.
  3. ↑ Mudbhary, Raksha; Hoshida, Yujin; Chernyavskaya, Yelena; Jacob, Vinitha; Villanueva, Augusto; Fiel, M. Isabel; Chen, Xintong; Kojima, Kensuke; Thung, Swan; Bronson, Roderick T.; Lachenmayer, Anja; Revill, Kate; Alsinet, Clara; Sachidanandam, Ravi; Desai, Anal; Senbanerjee, Sucharita; Ukomadu, Chinweike; Llovet, Josep M.; Sadler, Kirsten C. (2014). "UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma". Cancer Cell. 25 (2): 196–209. doi:10.1016/j.ccr.2014.01.003. PMC 3951208. PMID 24486181.

Further reading

  • Ku DH, Chang CD, Koniecki J, Cannizzaro LA, Boghosian-Sell L, Alder H, Baserga R (Apr 1991). "A new growth-regulated complementary DNA with the sequence of a putative trans-activating factor". Cell Growth & Differentiation. 2 (4): 179–86. PMID 1868030.
  • Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M (Sep 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549. Check date values in: |year= / |date= mismatch (help)
  • Hopfner R, Mousli M, Jeltsch JM, Voulgaris A, Lutz Y, Marin C, Bellocq JP, Oudet P, Bronner C (Jan 2000). "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression". Cancer Research. 60 (1): 121–8. PMID 10646863.
  • Hopfner R, Mousli M, Garnier JM, Redon R, du Manoir S, Chatton B, Ghyselinck N, Oudet P, Bronner C (Mar 2001). "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression". Gene. 266 (1–2): 15–23. doi:10.1016/S0378-1119(01)00371-7. PMID 11290415.
  • Mousli M, Hopfner R, Abbady AQ, Monté D, Jeanblanc M, Oudet P, Louis B, Bronner C (Jul 2003). "ICBP90 belongs to a new family of proteins with an expression that is deregulated in cancer cells". British Journal of Cancer. 89 (1): 120–7. doi:10.1038/sj.bjc.6601068. PMC 2394215. PMID 12838312.
  • Citterio E, Papait R, Nicassio F, Vecchi M, Gomiero P, Mantovani R, Di Fiore PP, Bonapace IM (Mar 2004). "Np95 is a histone-binding protein endowed with ubiquitin ligase activity". Molecular and Cellular Biology. 24 (6): 2526–35. doi:10.1128/MCB.24.6.2526-2535.2004. PMC 355858. PMID 14993289.
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