UGT1A6

UDP glucuronosyltransferase 1 family, polypeptide A6
Identifiers
Symbols	UGT1A6 ; UGT1; GNT1; UDPGT; HLUGP; HLUGP1; MGC29860; UGT1*6; UGT1F
External IDs	Template:OMIM5 Template:MGI HomoloGene: 85959
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

UDP glucuronosyltransferase 1 family, polypeptide A6, also known as UGT1A6, is a human gene.

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

Further reading

• Mackenzie PI, Owens IS, Burchell B; et al. (1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics. 7 (4): 255–69. PMID 9295054.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tukey RH, Strassburg CP (2000). "Human UDP-glucuronosyltransferases: metabolism, expression, and disease". Annu. Rev. Pharmacol. Toxicol. 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.
• King CD, Rios GR, Green MD, Tephly TR (2001). "UDP-glucuronosyltransferases". Curr. Drug Metab. 1 (2): 143–61. PMID 11465080.CS1 maint: Multiple names: authors list (link)
• Bock KW, Köhle C (2006). "UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects". Meth. Enzymol. 400: 57–75. doi:10.1016/S0076-6879(05)00004-2. PMID 16399343.
• Ritter JK, Chen F, Sheen YY; et al. (1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J. Biol. Chem. 267 (5): 3257–61. PMID 1339448.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bosma PJ, Chowdhury JR, Huang TJ; et al. (1992). "Mechanisms of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I.". FASEB J. 6 (10): 2859–63. PMID 1634050.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ritter JK, Crawford JM, Owens IS (1991). "Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells". J. Biol. Chem. 266 (2): 1043–7. PMID 1898728.CS1 maint: Multiple names: authors list (link)
• Harding D, Jeremiah SJ, Povey S, Burchell B (1990). "Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1". Ann. Hum. Genet. 54 (Pt 1): 17–21. PMID 2108603.CS1 maint: Multiple names: authors list (link)
• Harding D, Fournel-Gigleux S, Jackson MR, Burchell B (1988). "Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells". Proc. Natl. Acad. Sci. U.S.A. 85 (22): 8381–5. PMID 3141926.CS1 maint: Multiple names: authors list (link)
• Moghrabi N, Clarke DJ, Boxer M, Burchell B (1994). "Identification of an A-to-G missense mutation in exon 2 of the UGT1 gene complex that causes Crigler-Najjar syndrome type 2". Genomics. 18 (1): 171–3. doi:10.1006/geno.1993.1451. PMID 8276413.CS1 maint: Multiple names: authors list (link)
• Aono S, Yamada Y, Keino H; et al. (1994). "Identification of defect in the genes for bilirubin UDP-glucuronosyl-transferase in a patient with Crigler-Najjar syndrome type II". Biochem. Biophys. Res. Commun. 197 (3): 1239–44. doi:10.1006/bbrc.1993.2610. PMID 8280139.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Killard AJ, O'Kennedy R, Bogan DP (1997). "Analysis of the glucuronidation of 7-hydroxycoumarin by HPLC". Journal of pharmaceutical and biomedical analysis. 14 (11): 1585–90. PMID 8877866.CS1 maint: Multiple names: authors list (link)
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
• Ciotti M, Marrone A, Potter C, Owens IS (1998). "Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications". Pharmacogenetics. 7 (6): 485–95. PMID 9429234.CS1 maint: Multiple names: authors list (link)
• Münzel PA, Lehmköster T, Brück M; et al. (1998). "Aryl hydrocarbon receptor-inducible or constitutive expression of human UDP glucuronosyltransferase UGT1A6". Arch. Biochem. Biophys. 350 (1): 72–8. doi:10.1006/abbi.1997.0485. PMID 9466822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Duffy CF, O'Kennedy R (1999). "Determination of 7-hydroxycoumarin and its glucuronide and sulphate conjugates in liver slice incubates by capillary zone electrophoresis". Journal of pharmaceutical and biomedical analysis. 17 (8): 1279–84. PMID 9800648.
• Gong QH, Cho JW, Huang T; et al. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics. 11 (4): 357–68. PMID 11434514.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)