Tumor lysis syndrome causes: Difference between revisions

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==Overview==
==Overview==
The most common tumors associated with this syndrome are poorly differentiated lymphomas, such as [[Burkitt's lymphoma]], and leukemias, such as [[acute lymphoblastic leukemia]] (ALL) and [[acute myeloid leukemia]] (AML). Other cancers have also been associated with TLS but are less common. Usually, the precipitating medication regimen includes combination [[chemotherapy]], but those patients with lymphoma and ALL can be affected with [[steroid]] treatment alone.
The most common tumors associated with this syndrome are poorly differentiated lymphomas, such as [[Burkitt's lymphoma]], and leukemias, such as [[acute lymphoblastic leukemia]] (ALL) and [[acute myeloid leukemia]] (AML). Other cancers have also been associated with TLS but are less common. Usually, the precipitating medication regimen includes combination [[chemotherapy]], but those patients with lymphoma and ALL can be affected with [[steroid]] treatment alone.
==Cause==
==Causes==
===Life Threatening Causes===
===Common Causes===
===Common Causes===
*[[Burkitt's lymphoma]]
*[[Burkitt's lymphoma]]
Line 10: Line 11:
*[[Acute myeloid leukemia]]
*[[Acute myeloid leukemia]]
*[[Chemotherapy]]
*[[Chemotherapy]]
===Causes by Organ System===
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Heparin]], [[Combined oral contraceptive pill|oral contraceptives]], [[Thiazide|thiazide diuretics]]
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| [[Diabetes mellitus]], [[hypothyroidism]]
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| [[Glycogen storage disease type I]], [[lipoprotein lipase deficiency]], [[familial hyperchylomicronemia|type 1C hyperlipoproteinemia]], [[mixed hyperlipoproteinemia ]]
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| [[Familial hypertriglyceridemia]], [[glycogen storage disease type I]], [[lipoprotein lipase deficiency]]
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| [[Pregnancy]]
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| [[Alcoholism|Alcohol]]
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| [[Chronic renal failure]]
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| [[Autoimmune hyperchylomicronemia ]]<ref name="Yoshimura-1998">{{Cite journal  | last1 = Yoshimura | first1 = T. | last2 = Ito | first2 = M. | last3 = Sakoda | first3 = Y. | last4 = Kobori | first4 = S. | last5 = Okamura | first5 = H. | title = Rare case of autoimmune hyperchylomicronemia during pregnancy. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 76 | issue = 1 | pages = 49-51 | month = Jan | year = 1998 | doi =  | PMID = 9481547 }}</ref>
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
|-
|}
===Causes by Alphabetical Order===
{{col-begin|width=80%}}
{{col-break|width=33%}}
*[[Alcoholism]]
*Autoimmune hyperchylomicronemia<ref name="Yoshimura-1998">{{Cite journal  | last1 = Yoshimura | first1 = T. | last2 = Ito | first2 = M. | last3 = Sakoda | first3 = Y. | last4 = Kobori | first4 = S. | last5 = Okamura | first5 = H. | title = Rare case of autoimmune hyperchylomicronemia during pregnancy. | journal = Eur J Obstet Gynecol Reprod Biol | volume = 76 | issue = 1 | pages = 49-51 | month = Jan | year = 1998 | doi =  | PMID = 9481547 }}</ref>
*[[Chronic renal failure]]
*[[Diabetes mellitus]]
*[[Familial hyperchylomicronemia|Type 1B hyperlipoproteinemia]]
*[[Familial hypertriglyceridemia]]
*[[Glycogen storage disease type I]]
*[[Heparin]]
*[[Hypothyroidism]]
*[[Familial hyperchylomicronemia|Lipoprotein lipase deficiency]]
*[[Combined oral contraceptive pill|Oral contraceptives]]
*[[Pregnancy]]
*[[Thiazide|Thiazide diuretics]]
*[[Familial hyperchylomicronemia|Type 1C hyperlipoproteinemia]]
*[[Mixed hyperlipoproteinemia ]]
{{col-end}}
==References==
==References==
{{reflist|2}}
{{reflist|2}}

Revision as of 23:54, 4 February 2014

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

The most common tumors associated with this syndrome are poorly differentiated lymphomas, such as Burkitt's lymphoma, and leukemias, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). Other cancers have also been associated with TLS but are less common. Usually, the precipitating medication regimen includes combination chemotherapy, but those patients with lymphoma and ALL can be affected with steroid treatment alone.

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect Heparin, oral contraceptives, thiazide diuretics
Ear Nose Throat No underlying causes
Endocrine Diabetes mellitus, hypothyroidism
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic Glycogen storage disease type I, lipoprotein lipase deficiency, type 1C hyperlipoproteinemia, mixed hyperlipoproteinemia
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic Familial hypertriglyceridemia, glycogen storage disease type I, lipoprotein lipase deficiency
Obstetric/Gynecologic Pregnancy
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity Alcohol
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte Chronic renal failure
Rheumatology/Immunology/Allergy Autoimmune hyperchylomicronemia [1]
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes

Causes by Alphabetical Order

References

  1. ↑ 1.0 1.1 Yoshimura, T.; Ito, M.; Sakoda, Y.; Kobori, S.; Okamura, H. (1998). "Rare case of autoimmune hyperchylomicronemia during pregnancy". Eur J Obstet Gynecol Reprod Biol. 76 (1): 49–51. PMID 9481547. Unknown parameter |month= ignored (help)

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