Torsemide (tablet)

Torsemide (tablet)

Clinical data
AHFS/Drugs.com	International Drug Names
MedlinePlus	a601212
Pregnancy category	US: C (Risk not ruled out)
Routes of administration	Oral, IV
ATC code	C03CA04 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Elimination half-life	3.5 hours; Cirrhosis: 7-8 hours
Identifiers
IUPAC name N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
CAS Number	56211-40-6
PubChem CID	41781
DrugBank	DB00214 Y
ChemSpider	38123 Y
UNII	W31X2H97FB
KEGG	D00382 Y
ChEMBL	ChEMBL1148 Y
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H20N4O3S
Molar mass	348.421 g/mol
3D model (JSmol)	Interactive image
SMILES O=S(=O)(c2c(Nc1cc(ccc1)C)ccnc2)NC(=O)NC(C)C
InChI InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21) Y Key:NGBFQHCMQULJNZ-UHFFFAOYSA-N Y
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms / Brand Names: DEMADEX^®; generic

Overview

Torsemide is a diuretic of the pyridine-sulfonylurea class used in treatment of edema associated with congestive heart failure, renal disease, or hepatic disease.

Category

Loop Diuretic