Thiamphenicol

Thiamphenicol

Clinical data
Pregnancy category	?
Routes of administration	IV, IM, O
ATC code	J01BA02 (WHO)
Legal status
Legal status	none
Pharmacokinetic data
Bioavailability	?
Metabolism	hepatic
Elimination half-life	5.0 hours
Excretion	renal
Identifiers
IUPAC name 2,2-dichloro-N-[(1R,2R)- 1,3-dihydroxy-1- (4-methylsulfonylphenyl) propan-2-yl] acetamide
CAS Number	15318-45-3
PubChem CID	27200
DrugBank	?
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H15Cl2NO5S
Molar mass	356.223 g/mol

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Thiamphenicol is an antibiotic. It is the methyl-sulfonyl analogue of chloramphenicol and has a similar spectrum of activity, but is 2.5 to 5 times as potent. Like chloramphenicol, is insoluble in water but highly soluble in lipids. It is used in many countries as a veterinary antibiotic, but is available in China and Italy for use in humans. Its main advantage over chloramphenicol is that it has never been associated with aplastic anaemia.

Alternative names

• Dextrosulphenidol
• Thiophenicol

External links

• Overview at World Health Organization - Food and Agriculture Organization
• Raymond J, Boutros N, Bergeret M (2004). "Role of thiamphenicol in the treatment of community-acquired lung infections". Med Trop (Mars). 64 (1): 33–8. PMID 15224555.CS1 maint: Multiple names: authors list (link)
• Marchese A, Debbia E, Tonoli E, Gualco L, Schito A (2002). "In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy". J Chemother. 14 (6): 554–61. PMID 12583545.CS1 maint: Multiple names: authors list (link)