Testicular receptor 4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Testicular receptor 4''' also known as '''NR2C2''' (nuclear receptor subfamily 2, group C, member 2) is a [[protein]] that in humans is encoded by the ''NR2C2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2C2 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7182| accessdate = }}</ref><ref name="pmid8016112">{{cite journal | vauthors = Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP | title = Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 13 | pages = 6040–4 | date = Jun 1994 | pmid = 8016112 | pmc = 44133 | doi = 10.1073/pnas.91.13.6040 }}</ref><ref name="pmid8661150">{{cite journal | vauthors = Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD | title = New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene | journal = Genomics | volume = 35 | issue = 2 | pages = 361–6 | date = Jul 1996 | pmid = 8661150 | doi = 10.1006/geno.1996.0368 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The testicular receptor 4 is a member of the [[nuclear receptor]] family of [[transcription factor]]s.
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Nuclear receptor subfamily 2, group C, member 2
| HGNCid = 7972
| Symbol = NR2C2
| AltSymbols =; TAK1; TR2R1; TR4; hTAK1
| OMIM = 601426
| ECnumber = 
| Homologene = 2475
| MGIid = 1352466
| GeneAtlas_image1 = PBB_GE_NR2C2_206038_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0003707 |text = steroid hormone receptor activity}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0043565 |text = sequence-specific DNA binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007399 |text = nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7182
    | Hs_Ensembl = ENSG00000177463
    | Hs_RefseqProtein = NP_003289
    | Hs_RefseqmRNA = NM_003298
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 15020395
    | Hs_GenLoc_end = 15059704
    | Hs_Uniprot = P49116
    | Mm_EntrezGene = 22026
    | Mm_Ensembl = ENSMUSG00000005893
    | Mm_RefseqmRNA = XM_984385
    | Mm_RefseqProtein = XP_989479
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 92104498
    | Mm_GenLoc_end = 92133463
    | Mm_Uniprot = Q3U015
  }}
}}


'''Testicular receptor 4''' is a member of the [[nuclear receptor]] family of [[transcription factor]]s and is encoded by the {{gene|NR2C2}} gene (nuclear receptor subfamily 2, group C, member 2).<ref name="entrez">{{cite web | title = Entrez Gene: NR2C2 | url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7182| accessdate = }}</ref>
== Interactions ==


==See also==
Testicular receptor 4 has been shown to [[Protein-protein_interaction|interact]] with
* [[Androgen receptor]],<ref name="pmid10611280">{{cite journal | vauthors = Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C | title = Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 14724–9 | date = Dec 1999 | pmid = 10611280 | pmc = 24715 | doi = 10.1073/pnas.96.26.14724 }}</ref>
* [[Estrogen receptor alpha]],<ref name="pmid11844790">{{cite journal | vauthors = Shyr CR, Hu YC, Kim E, Chang C | title = Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 14622–8 | date = Apr 2002 | pmid = 11844790 | doi = 10.1074/jbc.M110051200 }}</ref> and
* [[Hepatocyte nuclear factor 4 alpha]].<ref name="pmid12522137">{{cite journal | vauthors = Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C | title = Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 11 | pages = 9353–60 | date = Mar 2003 | pmid = 12522137 | doi = 10.1074/jbc.M205944200 }}</ref>
 
== See also ==
* [[Testicular receptor]]
* [[Testicular receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
 
{{clear}}
==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin|33em}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hirose T, Fujimoto W, Tamaai T, Kim KH, Matsuura H, Jetten AM | title = TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily | journal = Molecular Endocrinology | volume = 8 | issue = 12 | pages = 1667–80 | date = Dec 1994 | pmid = 7708055 | doi = 10.1210/me.8.12.1667 | url = https://zenodo.org/record/1236241/files/article.pdf }}
| citations =
* {{cite journal | vauthors = Young WJ, Smith SM, Chang C | title = Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily | journal = The Journal of Biological Chemistry | volume = 272 | issue = 5 | pages = 3109–16 | date = Jan 1997 | pmid = 9006963 | doi = 10.1074/jbc.272.5.3109 }}
*{{cite journal | author=Hirose T, Fujimoto W, Tamaai T, ''et al.'' |title=TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily. |journal=Mol. Endocrinol. |volume=8 |issue= 12 |pages= 1667-80 |year= 1995 |pmid= 7708055 |doi= }}
* {{cite journal | vauthors = Lee CH, Chinpaisal C, Wei LN | title = A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 39 | pages = 25209–15 | date = Sep 1998 | pmid = 9737983 | doi = 10.1074/jbc.273.39.25209 }}
*{{cite journal  | author=Chang C, Da Silva SL, Ideta R, ''et al.'' |title=Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 13 |pages= 6040-4 |year= 1994 |pmid= 8016112 |doi=  }}
* {{cite journal | vauthors = Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C | title = Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 26 | pages = 14724–9 | date = Dec 1999 | pmid = 10611280 | pmc = 24715 | doi = 10.1073/pnas.96.26.14724 }}
*{{cite journal  | author=Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD |title=New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene. |journal=Genomics |volume=35 |issue= 2 |pages= 361-6 |year= 1996 |pmid= 8661150 |doi= 10.1006/geno.1996.0368 }}
* {{cite journal | vauthors = Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C | title = Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40417–23 | date = Nov 2001 | pmid = 11509567 | doi = 10.1074/jbc.M104765200 }}
*{{cite journal | author=Young WJ, Smith SM, Chang C |title=Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily. |journal=J. Biol. Chem. |volume=272 |issue= 5 |pages= 3109-16 |year= 1997 |pmid= 9006963 |doi= }}
* {{cite journal | vauthors = Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM | title = Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation | journal = Molecular and Cellular Biology | volume = 21 | issue = 21 | pages = 7207–17 | date = Nov 2001 | pmid = 11585904 | pmc = 99896 | doi = 10.1128/MCB.21.21.7207-7217.2001 }}
*{{cite journal | author=Lee CH, Chinpaisal C, Wei LN |title=A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4. |journal=J. Biol. Chem. |volume=273 |issue= 39 |pages= 25209-15 |year= 1998 |pmid= 9737983 |doi= }}
* {{cite journal | vauthors = Shyr CR, Hu YC, Kim E, Chang C | title = Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 17 | pages = 14622–8 | date = Apr 2002 | pmid = 11844790 | doi = 10.1074/jbc.M110051200 }}
*{{cite journal | author=Lee YF, Shyr CR, Thin TH, ''et al.'' |title=Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 26 |pages= 14724-9 |year= 2000 |pmid= 10611280 |doi= }}
* {{cite journal | vauthors = Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD | title = An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3434–42 | date = Jul 2002 | pmid = 12093744 | pmc = 126089 | doi = 10.1093/emboj/cdf340 }}
*{{cite journal | author=Wang X, Yeh S, Wu G, ''et al.'' |title=Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40417-23 |year= 2001 |pmid= 11509567 |doi= 10.1074/jbc.M104765200 }}
* {{cite journal | vauthors = Yang Y, Wang X, Dong T, Kim E, Lin WJ, Chang C | title = Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation | journal = The Journal of Biological Chemistry | volume = 278 | issue = 9 | pages = 7709–17 | date = Feb 2003 | pmid = 12486131 | doi = 10.1074/jbc.M207116200 }}
*{{cite journal | author=Yeung KC, Rose DW, Dhillon AS, ''et al.'' |title=Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. |journal=Mol. Cell. Biol. |volume=21 |issue= 21 |pages= 7207-17 |year= 2001 |pmid= 11585904 |doi= 10.1128/MCB.21.21.7207-7217.2001 }}
* {{cite journal | vauthors = Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C | title = Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 11 | pages = 9353–60 | date = Mar 2003 | pmid = 12522137 | doi = 10.1074/jbc.M205944200 }}
*{{cite journal | author=Shyr CR, Hu YC, Kim E, Chang C |title=Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 14622-8 |year= 2002 |pmid= 11844790 |doi= 10.1074/jbc.M110051200 }}
* {{cite journal | vauthors = Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB | title = TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway | journal = Journal of Molecular Biology | volume = 326 | issue = 1 | pages = 105–15 | date = Feb 2003 | pmid = 12547194 | doi = 10.1016/S0022-2836(02)01404-3 }}
*{{cite journal | author=Tanabe O, Katsuoka F, Campbell AD, ''et al.'' |title=An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3434-42 |year= 2002 |pmid= 12093744 |doi= 10.1093/emboj/cdf340 }}
* {{cite journal | vauthors = Inui S, Lee YF, Chang E, Shyr CR, Chang C | title = Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes | journal = Journal of Dermatological Science | volume = 31 | issue = 1 | pages = 65–71 | date = Feb 2003 | pmid = 12615366 | doi = 10.1016/S0923-1811(02)00152-4 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K | title = Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling | journal = The EMBO Journal | volume = 22 | issue = 23 | pages = 6277–88 | date = Dec 2003 | pmid = 14633987 | pmc = 291846 | doi = 10.1093/emboj/cdg605 }}
*{{cite journal  | author=Yang Y, Wang X, Dong T, ''et al.'' |title=Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7709-17 |year= 2003 |pmid= 12486131 |doi= 10.1074/jbc.M207116200 }}
* {{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1 | journal = The Biochemical Journal | volume = 378 | issue = Pt 1 | pages = 27–34 | date = Feb 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}
*{{cite journal | author=Lin WJ, Li J, Lee YF, ''et al.'' |title=Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4. |journal=J. Biol. Chem. |volume=278 |issue= 11 |pages= 9353-60 |year= 2003 |pmid= 12522137 |doi= 10.1074/jbc.M205944200 }}
* {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nature Cell Biology | volume = 6 | issue = 2 | pages = 97–105 | date = Feb 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
*{{cite journal | author=Takaesu G, Surabhi RM, Park KJ, ''et al.'' |title=TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway. |journal=J. Mol. Biol. |volume=326 |issue= 1 |pages= 105-15 |year= 2003 |pmid= 12547194 |doi= }}
*{{cite journal | author=Inui S, Lee YF, Chang E, ''et al.'' |title=Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes. |journal=J. Dermatol. Sci. |volume=31 |issue= 1 |pages= 65-71 |year= 2003 |pmid= 12615366 |doi= }}
*{{cite journal | author=Ishitani T, Takaesu G, Ninomiya-Tsuji J, ''et al.'' |title=Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling. |journal=EMBO J. |volume=22 |issue= 23 |pages= 6277-88 |year= 2004 |pmid= 14633987 |doi= 10.1093/emboj/cdg605 }}
*{{cite journal | author=Cheung PC, Nebreda AR, Cohen P |title=TAB3, a new binding partner of the protein kinase TAK1. |journal=Biochem. J. |volume=378 |issue= Pt 1 |pages= 27-34 |year= 2004 |pmid= 14670075 |doi= 10.1042/BJ20031794 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
}}
{{refend}}
{{refend}}
 
== External links ==
{{protein-stub}}
* {{FactorBook|TR4}}
{{Transcription factors}}
{{Transcription factors|g2}}
[[Category:Intracellular receptors]]
[[Category:Intracellular receptors]]
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{WikiDoc Sources}}
 
{{gene-3-stub}}

Latest revision as of 08:20, 27 October 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[1][2][3]

The testicular receptor 4 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 4 has been shown to interact with

See also

References

  1. ↑ "Entrez Gene: NR2C2".
  2. ↑ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133. PMID 8016112.
  3. ↑ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (Jul 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
  4. ↑ Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (Dec 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America. 96 (26): 14724–9. doi:10.1073/pnas.96.26.14724. PMC 24715. PMID 10611280.
  5. ↑ Shyr CR, Hu YC, Kim E, Chang C (Apr 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry. 277 (17): 14622–8. doi:10.1074/jbc.M110051200. PMID 11844790.
  6. ↑ Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (Mar 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry. 278 (11): 9353–60. doi:10.1074/jbc.M205944200. PMID 12522137.

Further reading

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Testicular_receptor_4&oldid=1532269"