Tabes Dorsalis overview

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Tabes Dorsalis Microchapters

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Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Tabes Dorsalis from other Diseases

Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Tabes dorsalis is a slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The degenerating nerves are in the dorsal columns of the spinal cord (the portion closest to the back of the body) and carry information that help maintain a person's sense of position.

Causes

Tabes dorsalis is a form of neurosyphilis, which is a complication of late or tertiary syphilis infection. Syphilis is a sexually transmitted, infectious disease. The infection damages the spinal cord and peripheral nervous tissue.

Epidemiology and Demographics

Tabes dorsalis is now very rare because syphilis is usually treated early in the disease.

Diagnosis

CT

A head CT or a spine CT can be performed on the brain and spinal cord to help rule out other diseases.

MRI

An MRI scan can be performed on the brain and spinal cord to help rule out other diseases.

Treatment

Medical Therapy

Penicillin, administered intravenously, is the treatment of choice. Associated pain can be treated with opiates, valproate, or carbamazepine. Patients may also require physical or rehabilitative therapy to deal with muscle wasting and weakness. Preventive treatment for those who come into sexual contact with an individual with tabes dorsalis is important.

References

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