TTK (gene)

TTK protein kinase
Identifiers
Symbols	TTK ; ESK; FLJ38280; MPS1L1; PYT
External IDs	Template:OMIM5 Template:MGI HomoloGene: 2489
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TTK 204822 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

TTK protein kinase, also known as TTK, is a human gene.

Further reading

• Mills GB, Schmandt R, McGill M; et al. (1992). "Expression of TTK, a novel human protein kinase, is associated with cell proliferation". J. Biol. Chem. 267 (22): 16000–6. PMID 1639825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hanks SK, Quinn AM (1991). "Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members". Meth. Enzymol. 200: 38–62. PMID 1956325.
• Lindberg RA, Fischer WH, Hunter T (1993). "Characterization of a human protein threonine kinase isolated by screening an expression library with antibodies to phosphotyrosine". Oncogene. 8 (2): 351–9. PMID 7678926.CS1 maint: Multiple names: authors list (link)
• Lauzé E, Stoelcker B, Luca FC; et al. (1995). "Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase". EMBO J. 14 (8): 1655–63. PMID 7737118.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cahill DP, da Costa LT, Carson-Walter EB; et al. (1999). "Characterization of MAD2B and other mitotic spindle checkpoint genes". Genomics. 58 (2): 181–7. doi:10.1006/geno.1999.5831. PMID 10366450.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Weinmann AS, Yan PS, Oberley MJ; et al. (2002). "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. doi:10.1101/gad.943102. PMID 11799066.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stucke VM, Silljé HH, Arnaud L, Nigg EA (2002). "Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication". EMBO J. 21 (7): 1723–32. doi:10.1093/emboj/21.7.1723. PMID 11927556.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Liu ST, Chan GK, Hittle JC; et al. (2003). "Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores". Mol. Biol. Cell. 14 (4): 1638–51. doi:10.1091/mbc.02-05-0074. PMID 12686615.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fisk HA, Mattison CP, Winey M (2004). "Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 14875–80. doi:10.1073/pnas.2434156100. PMID 14657364.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dou Z, Ding X, Zereshki A; et al. (2004). "TTK kinase is essential for the centrosomal localization of TACC2". FEBS Lett. 572 (1–3): 51–6. doi:10.1016/j.febslet.2004.06.092. PMID 15304323.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wei JH, Chou YF, Ou YH; et al. (2005). "TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68". J. Biol. Chem. 280 (9): 7748–57. doi:10.1074/jbc.M410152200. PMID 15618221.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Camacho E, Beà S, Salaverría I; et al. (2006). "Analysis of Aurora-A and hMPS1 mitotic kinases in mantle cell lymphoma". Int. J. Cancer. 118 (2): 357–63. doi:10.1002/ijc.21370. PMID 16080195.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Leng M, Chan DW, Luo H; et al. (2006). "MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability". Proc. Natl. Acad. Sci. U.S.A. 103 (31): 11485–90. doi:10.1073/pnas.0601828103. PMID 16864798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bertheau P, Turpin E, Rickman DS; et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen". PLoS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMID 17388661.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhu S, Wang W, Clarke DC, Liu X (2007). "Activation of Mps1 promotes transforming growth factor-beta-independent Smad signaling". J. Biol. Chem. 282 (25): 18327–38. doi:10.1074/jbc.M700636200. PMID 17452325.CS1 maint: Multiple names: authors list (link)
• Kanai M, Ma Z, Izumi H; et al. (2007). "Physical and functional interaction between mortalin and Mps1 kinase". Genes Cells. 12 (6): 797–810. doi:10.1111/j.1365-2443.2007.01091.x. PMID 17573779.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mattison CP, Old WM, Steiner E; et al. (2007). "Mps1 activation loop autophosphorylation enhances kinase activity". J. Biol. Chem. 282 (42): 30553–61. doi:10.1074/jbc.M707063200. PMID 17728254.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)