TRIP6

Thyroid hormone receptor interactor 6
File:PBB Protein TRIP6 image.jpg PDB rendering based on 1x61.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1x61​, 2dlo​
Identifiers
Symbols	TRIP6 ; MGC10556; MGC10558; MGC29959; MGC3837; MGC4423; OIP1; ZRP-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37757
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TRIP6 209129 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Thyroid hormone receptor interactor 6, also known as TRIP6, is a human gene.

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Further reading

• Lee JW, Choi HS, Gyuris J; et al. (1995). "Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor". Mol. Endocrinol. 9 (2): 243–54. PMID 7776974.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Williams JM, Chen GC, Zhu L, Rest RF (1998). "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth". Mol. Microbiol. 27 (1): 171–86. PMID 9466265.CS1 maint: Multiple names: authors list (link)
• Yi J, Beckerle MC (1998). "The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis". Genomics. 49 (2): 314–6. doi:10.1006/geno.1998.5248. PMID 9598321.
• Murthy KK, Clark K, Fortin Y; et al. (1999). "ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E". J. Biol. Chem. 274 (29): 20679–87. PMID 10400701.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zhao MK, Wang Y, Murphy K; et al. (2000). "LIM domain-containing protein trip6 can act as a coactivator for the v-Rel transcription factor". Gene Expr. 8 (4): 207–17. PMID 10794523.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cuppen E, van Ham M, Wansink DG; et al. (2000). "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP-BL". Eur. J. Cell Biol. 79 (4): 283–93. PMID 10826496.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wilson MD, Riemer C, Martindale DW; et al. (2001). "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5". Nucleic Acids Res. 29 (6): 1352–65. PMID 11239002.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang Y, Gilmore TD (2001). "LIM domain protein Trip6 has a conserved nuclear export signal, nuclear targeting sequences, and multiple transactivation domains". Biochim. Biophys. Acta. 1538 (2–3): 260–72. PMID 11336797.
• Yi J, Kloeker S, Jensen CC; et al. (2002). "Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers". J. Biol. Chem. 277 (11): 9580–9. doi:10.1074/jbc.M106922200. PMID 11782456.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Zarsky HA, Tarnasky HA, Cheng M, van der Hoorn FA (2003). "Novel RING finger protein OIP1 binds to conserved amino acid repeats in sperm tail protein ODF1". Biol. Reprod. 68 (2): 543–52. PMID 12533418.CS1 maint: Multiple names: authors list (link)
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263.CS1 maint: Multiple names: authors list (link)
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Sanz-Rodriguez F, Guerrero-Esteo M, Botella LM; et al. (2004). "Endoglin regulates cytoskeletal organization through binding to ZRP-1, a member of the Lim family of proteins". J. Biol. Chem. 279 (31): 32858–68. doi:10.1074/jbc.M400843200. PMID 15148318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kassel O, Schneider S, Heilbock C; et al. (2004). "A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB-regulated promoters". Genes Dev. 18 (20): 2518–28. doi:10.1101/gad.322404. PMID 15489293.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Li L, Bin LH, Li F; et al. (2005). "TRIP6 is a RIP2-associated common signaling component of multiple NF-kappaB activation pathways". J. Cell. Sci. 118 (Pt 3): 555–63. doi:10.1242/jcs.01641. PMID 15657077.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Petit MM, Crombez KR, Vervenne HB; et al. (2005). "The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins". FEBS Lett. 579 (22): 5061–8. doi:10.1016/j.febslet.2005.08.012. PMID 16137684.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)