TP53BP2

Tumor protein p53 binding protein, 2
File:PBB Protein TP53BP2 image.jpg PDB rendering based on 1ycs.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1ycs​
Identifiers
Symbols	TP53BP2 ; 53BP2; ASPP2; BBP; PPP1R13A; p53BP2
External IDs	Template:OMIM5 Template:MGI HomoloGene: 3959
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TP53BP2 203120 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Tumor protein p53 binding protein, 2, also known as TP53BP2, is a human gene.

This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene.

Further reading

• Liu ZJ, Lu X, Zhong S (2005). "ASPP--Apoptotic specific regulator of p53". Biochim. Biophys. Acta. 1756 (1): 77–80. doi:10.1016/j.bbcan.2005.08.002. PMID 16139958.CS1 maint: Multiple names: authors list (link)
• Iwabuchi K, Bartel PL, Li B; et al. (1994). "Two cellular proteins that bind to wild-type but not mutant p53". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6098–102. PMID 8016121.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Helps NR, Barker HM, Elledge SJ, Cohen PT (1996). "Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53". FEBS Lett. 377 (3): 295–300. doi:10.1016/0014-5793(95)01347-4. PMID 8549741.CS1 maint: Multiple names: authors list (link)
• Naumovski L, Cleary ML (1996). "The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M". Mol. Cell. Biol. 16 (7): 3884–92. PMID 8668206.
• Gorina S, Pavletich NP (1996). "Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2". Science. 274 (5289): 1001–5. PMID 8875926.
• Pirozzi G, McConnell SJ, Uveges AJ; et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. PMID 9169421.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang JP, Ono T, Sonta S; et al. (1997). "Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization". Cytogenet. Cell Genet. 78 (1): 61–2. PMID 9345910.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Iwabuchi K, Li B, Massa HF; et al. (1998). "Stimulation of p53-mediated transcriptional activation by the p53-binding proteins, 53BP1 and 53BP2". J. Biol. Chem. 273 (40): 26061–8. PMID 9748285.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Yang JP, Hori M, Takahashi N; et al. (1999). "NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2". Oncogene. 18 (37): 5177–86. doi:10.1038/sj.onc.1202904. PMID 10498867.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Scanlan MJ, Gordan JD, Williamson B; et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. PMID 10508479.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mori T, Okamoto H, Takahashi N; et al. (2000). "Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines". FEBS Lett. 465 (2–3): 124–8. PMID 10631318.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nakagawa H, Koyama K, Murata Y; et al. (2000). "APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus". Cancer Res. 60 (1): 101–5. PMID 10646860.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lopez CD, Ao Y, Rohde LH; et al. (2000). "Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53". Mol. Cell. Biol. 20 (21): 8018–25. PMID 11027272.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Espanel X, Sudol M (2001). "Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains". J. Biol. Chem. 276 (17): 14514–23. doi:10.1074/jbc.M008568200. PMID 11278422.
• Kajkowski EM, Lo CF, Ning X; et al. (2001). "beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module". J. Biol. Chem. 276 (22): 18748–56. doi:10.1074/jbc.M011161200. PMID 11278849.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Samuels-Lev Y, O'Connor DJ, Bergamaschi D; et al. (2001). "ASPP proteins specifically stimulate the apoptotic function of p53". Mol. Cell. 8 (4): 781–94. PMID 11684014.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Chen Y, Liu W, Naumovski L, Neve RL (2003). "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis". J. Neurochem. 85 (3): 801–9. PMID 12694406.CS1 maint: Multiple names: authors list (link)
• Bergamaschi D, Samuels Y, Jin B; et al. (2004). "ASPP1 and ASPP2: common activators of p53 family members". Mol. Cell. Biol. 24 (3): 1341–50. PMID 14729977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takahashi N, Kobayashi S, Jiang X; et al. (2004). "Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing". Biochem. Biophys. Res. Commun. 315 (2): 434–8. doi:10.1016/j.bbrc.2004.01.079. PMID 14766226.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)