TNRC6A

Revision as of 15:19, 6 September 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search


Trinucleotide repeat containing 6A
Identifiers
Symbols TNRC6A ; CAGH26; DKFZp666E117; FLJ22043; GW1; GW182; KIAA1460; MGC75384; TNRC6
External IDs Template:OMIM5 Template:MGI HomoloGene: 41399
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Trinucleotide repeat containing 6A, also known as TNRC6A, is a human gene.[1]

This gene encodes a member of the trinucleotide repeat containing 6 protein family. The protein functions in post-transcriptional gene silencing through the RNA interference (RNAi) and microRNA pathways. The protein associates with messenger RNAs and Argonaute proteins in cytoplasmic bodies known as GW-bodies or P-bodies. Inhibiting expression of this gene delocalizes other GW-body proteins and impairs RNAi and microRNA-induced gene silencing.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: TNRC6A trinucleotide repeat containing 6A".

Further reading

  • Yamagata K, Takeda J, Menzel S; et al. (1996). "Searching for NIDDM susceptibility genes: studies of genes with triplet repeats expressed in skeletal muscle". Diabetologia. 39 (6): 725–30. PMID 8781769.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.
  • Margolis RL, Abraham MR, Gatchell SB; et al. (1997). "cDNAs with long CAG trinucleotide repeats from human brain". Hum. Genet. 100 (1): 114–22. PMID 9225980.
  • Dias Neto E, Correa RG, Verjovski-Almeida S; et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
  • Nagase T, Kikuno R, Ishikawa K; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. PMID 10819331.
  • Eystathioy T, Chan EK, Tenenbaum SA; et al. (2002). "A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles". Mol. Biol. Cell. 13 (4): 1338–51. doi:10.1091/mbc.01-11-0544. PMID 11950943.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Eystathioy T, Chan EK, Mahler M; et al. (2004). "A panel of monoclonal antibodies to cytoplasmic GW bodies and the mRNA binding protein GW182". Hybrid. Hybridomics. 22 (2): 79–86. doi:10.1089/153685903321947996. PMID 12831532.
  • Eystathioy T, Jakymiw A, Chan EK; et al. (2003). "The GW182 protein colocalizes with mRNA degradation associated proteins hDcp1 and hLSm4 in cytoplasmic GW bodies". RNA. 9 (10): 1171–3. PMID 13130130.
  • Eystathioy T, Chan EK, Takeuchi K; et al. (2004). "Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182". J. Mol. Med. 81 (12): 811–8. doi:10.1007/s00109-003-0495-y. PMID 14598044.
  • Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
  • Yang Z, Jakymiw A, Wood MR; et al. (2005). "GW182 is critical for the stability of GW bodies expressed during the cell cycle and cell proliferation". J. Cell. Sci. 117 (Pt 23): 5567–78. doi:10.1242/jcs.01477. PMID 15494374.
  • Sen GL, Blau HM (2005). "Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies". Nat. Cell Biol. 7 (6): 633–6. doi:10.1038/ncb1265. PMID 15908945.
  • Rehwinkel J, Behm-Ansmant I, Gatfield D, Izaurralde E (2005). "A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing". RNA. 11 (11): 1640–7. doi:10.1261/rna.2191905. PMID 16177138.
  • Jakymiw A, Lian S, Eystathioy T; et al. (2006). "Disruption of GW bodies impairs mammalian RNA interference". Nat. Cell Biol. 7 (12): 1267–74. doi:10.1038/ncb1334. PMID 16284622.
  • Liu J, Rivas FV, Wohlschlegel J; et al. (2006). "A role for the P-body component GW182 in microRNA function". Nat. Cell Biol. 7 (12): 1261–6. doi:10.1038/ncb1333. PMID 16284623.
  • Lian S, Jakymiw A, Eystathioy T; et al. (2007). "GW bodies, microRNAs and the cell cycle". Cell Cycle. 5 (3): 242–5. PMID 16418578.
  • Behm-Ansmant I, Rehwinkel J, Doerks T; et al. (2006). "mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes". Genes Dev. 20 (14): 1885–98. doi:10.1101/gad.1424106. PMID 16815998.
  • Schneider MD, Najand N, Chaker S; et al. (2006). "Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development". J. Cell Biol. 174 (3): 349–58. doi:10.1083/jcb.200512103. PMID 16880270.

Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=TNRC6A&oldid=726883"