TCL1A

T-cell leukemia/lymphoma 1A
File:PBB Protein TCL1A image.jpg PDB rendering based on 1jsg.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1jsg​
Identifiers
Symbols	TCL1A ; TCL1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 7565
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO
RNA expression pattern
File:PBB GE TCL1A 39318 at tn.png
File:PBB GE TCL1A 209995 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

T-cell leukemia/lymphoma 1A, also known as TCL1A, is a human gene. It is encoding a TCL GTPase.

Further reading

• Pekarsky Y, Hallas C, Croce CM (2001). "The role of TCL1 in human T-cell leukemia". Oncogene. 20 (40): 5638–43. doi:10.1038/sj.onc.1204596. PMID 11607815.CS1 maint: Multiple names: authors list (link)
• Pekarsky Y, Zanesi N, Aqeilan R, Croce CM (2004). "Tcl1 as a model for lymphomagenesis". Hematol. Oncol. Clin. North Am. 18 (4): 863–79, ix. doi:10.1016/j.hoc.2004.04.007. PMID 15325703.CS1 maint: Multiple names: authors list (link)
• Noguchi M, Ropars V, Roumestand C, Suizu F (2007). "Proto-oncogene TCL1: more than just a coactivator for Akt". FASEB J. 21 (10): 2273–84. doi:10.1096/fj.06-7684com. PMID 17360849.CS1 maint: Multiple names: authors list (link)
• Russo G, Isobe M, Gatti R; et al. (1989). "Molecular analysis of a t(14;14) translocation in leukemic T-cells of an ataxia telangiectasia patient". Proc. Natl. Acad. Sci. U.S.A. 86 (2): 602–6. PMID 2783489.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Virgilio L, Narducci MG, Isobe M; et al. (1995). "Identification of the TCL1 gene involved in T-cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12530–4. PMID 7809072.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fu TB, Virgilio L, Narducci MG; et al. (1995). "Characterization and localization of the TCL-1 oncogene product". Cancer Res. 54 (24): 6297–301. PMID 7987816.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hoh F, Yang YS, Guignard L; et al. (1998). "Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology". Structure. 6 (2): 147–55. PMID 9519406.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Takizawa J, Suzuki R, Kuroda H; et al. (1998). "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia". Jpn. J. Cancer Res. 89 (7): 712–8. PMID 9738977.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pekarsky Y, Hallas C, Isobe M; et al. (1999). "Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2949–51. PMID 10077617.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laine J, Künstle G, Obata T; et al. (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. PMID 10983986.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi:10.1074/jbc.M107069200. PMID 11707444.CS1 maint: Multiple names: authors list (link)
• French SW, Shen RR, Koh PJ; et al. (2002). "A modeled hydrophobic domain on the TCL1 oncoprotein mediates association with AKT at the cytoplasmic membrane". Biochemistry. 41 (20): 6376–82. PMID 12009899.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fears S, Chakrabarti SR, Nucifora G, Rowley JD (2002). "Differential expression of TCL1 during pre-B-cell acute lymphoblastic leukemia progression". Cancer Genet. Cytogenet. 135 (2): 110–9. PMID 12127395.CS1 maint: Multiple names: authors list (link)
• Hoyer KK, French SW, Turner DE; et al. (2002). "Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14392–7. doi:10.1073/pnas.212410199. PMID 12381789.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• French SW, Malone CS, Shen RR; et al. (2003). "Sp1 transactivation of the TCL1 oncogene". J. Biol. Chem. 278 (2): 948–55. doi:10.1074/jbc.M207166200. PMID 12421830.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Herling M, Teitell MA, Shen RR; et al. (2004). "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin". Blood. 101 (12): 5007–9. doi:10.1182/blood-2002-10-3297. PMID 12576313.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kiss C, Nishikawa J, Takada K; et al. (2003). "T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4813–8. doi:10.1073/pnas.0730710100. PMID 12672960.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)