Syndrome of inappropriate antidiuretic hormone natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
The symptoms of SIADH can occur at any age. If left untreated can lead to complications, such as confusion, seizures, stupor, and coma.
Natural History, Complications, and Prognosis
- The symptoms of SIADH can occur at any age. If left untreated can lead to complications, such as confusion, seizures, stupor, and coma.
Complications
- Some of the complications of SIADH treatment are include cerebral edema and central pontine myelinolysis, which are seen with rapid sodium correction.
Prognosis
- The prognosis of Syndrome of inappropriate antidiuretic hormone (SIADH) depends primarily on its cause.
- If the cause is medications, SIADH usually improves after discontinuing the medication.
- SIADH secondary to an infection, improves with the treatment of the infection.
- SIADH secondary to cancers, has poor outcome.
- Patients with SIADH have different signs, symptoms and prognosis depending on the etiology of SIADH. Serum sodium concentration at short-term follow-up is predictive of long-term survival. Rapid correction of serum sodium concentration can lead to various complications. [1]
References
- ↑ Tzoulis P, Carr H, Bagkeris E, Bouloux PM (2017). "Improving care and outcomes of inpatients with syndrome of inappropriate antidiuresis (SIAD): a prospective intervention study of intensive endocrine input vs. routine care". Endocrine. 55 (2): 539–546. doi:10.1007/s12020-016-1161-9. PMC 5272879. PMID 27837439.