Syndrome of inappropriate antidiuretic hormone natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

Patients with SIADH have different characteristics and a different prognosis according to SIADH etiology. Serum sodium concentration at short-term follow-up is predictive of long-term survival. These findings might have diagnostic and treatment-related implications.

Natural History

If left untreated 2.5%-30% of hospitalized patients with SIADH may progress to develop

• Hyponatremia(Serum sodium concentration at short-term follow-up is predictive of long-term survival). T
• Cerebral edema
• Central pontine myelinolysis(if sodium levels are corrected too rapidly)

Complications

Common complications of SIADH are:

• Hyponatremia
• Central pontine myelinolysis ( When sodium levels are corrected too rapidly)
• Cerebral edema

Prognosis

The prognosis of (disease name) is poor/good with treatment. Without treatment, (disease name) will result in ___. (Disease name) is associated with a 1/5/10 year mortality of __ among patient with ______ (for example high grade lesions). The presence of ___ is associated with a particularly poor prognosis among patients with (disease nam

References

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