Structure specific recognition protein 1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''FACT complex subunit SSRP1''' also known as '''structure specific recognition protein 1''' is a [[protein]] that in humans is encoded by the SSRP1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SSRP1 structure specific recognition protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6749| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Structure specific recognition protein 1
| HGNCid = 11327
| Symbol = SSRP1
| AltSymbols =; FACT; FACT80; T160
| OMIM = 604328
| ECnumber = 
| Homologene = 2370
| MGIid = 107912
| GeneAtlas_image1 = PBB_GE_SSRP1_200957_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SSRP1_200956_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6749
    | Hs_Ensembl = ENSG00000149136
    | Hs_RefseqProtein = NP_003137
    | Hs_RefseqmRNA = NM_003146
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 56850036
    | Hs_GenLoc_end = 56859927
    | Hs_Uniprot = Q08945
    | Mm_EntrezGene = 20833
    | Mm_Ensembl = ENSMUSG00000027067
    | Mm_RefseqmRNA = NM_182990
    | Mm_RefseqProtein = NP_892035
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 84838111
    | Mm_GenLoc_end = 84847948
    | Mm_Uniprot = Q05DR5
  }}
}}
'''Structure specific recognition protein 1''', also known as '''SSRP1''', is a human protein.<ref name="entrez">{{cite web | title = Entrez Gene: SSRP1 structure specific recognition protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6749| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor [[FACT (biology)|FACT]]. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a [[high mobility group]] box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor [[FACT_(biology)|FACT]]. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a [[High mobility group|high mobility group]] box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.<ref name="entrez">{{cite web | title = Entrez Gene: SSRP1 structure specific recognition protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6749| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
Structure specific recognition protein 1 has been shown to [[Protein-protein interaction|interact]] with [[NEK9]].<ref name=pmid14660563>{{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 9321–30 | date = Mar 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 }}</ref>
SSRP1 further interacts with transcriptional activator [[tp63|p63]].<ref name=pmid12374749>{{cite journal | vauthors = Zeng SX, Dai MS, Keller DM, Lu H | title = SSRP1 functions as a co-activator of the transcriptional activator p63 | journal = EMBO J. | volume = 21 | issue = 20 | pages = 5487–97 | date = 15 Oct 2002 | pmid = 12374749 | pmc = 129072 | doi = 10.1093/emboj/cdf540 }}</ref> SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bruhn SL, Pil PM, Essigmann JM, Housman DE, Lippard SJ | title = Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 6 | pages = 2307–11 | year = 1992 | pmid = 1372440 | pmc = 48646 | doi = 10.1073/pnas.89.6.2307 }}
| citations =
* {{cite journal | vauthors = Toney JH, Donahue BA, Kellett PJ, Bruhn SL, Essigmann JM, Lippard SJ | title = Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II) | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 86 | issue = 21 | pages = 8328–32 | year = 1989 | pmid = 2530581 | pmc = 298274 | doi = 10.1073/pnas.86.21.8328 }}
*{{cite journal | author=Bruhn SL, Pil PM, Essigmann JM, ''et al.'' |title=Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 6 |pages= 2307-11 |year= 1992 |pmid= 1372440 |doi= }}
* {{cite journal | vauthors = Nagulapalli S, Pongubala JM, Atchison ML | title = Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). | journal = J. Immunol. | volume = 155 | issue = 9 | pages = 4330–8 | year = 1995 | pmid = 7594592 | doi =  }}
*{{cite journal  | author=Toney JH, Donahue BA, Kellett PJ, ''et al.'' |title=Isolation of cDNAs encoding a human protein that binds selectively to DNA modified by the anticancer drug cis-diamminedichloroplatinum(II) |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 21 |pages= 8328-32 |year= 1989 |pmid= 2530581 |doi= }}
* {{cite journal | vauthors = Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D | title = FACT, a factor that facilitates transcript elongation through nucleosomes. | journal = Cell | volume = 92 | issue = 1 | pages = 105–16 | year = 1998 | pmid = 9489704 | doi = 10.1016/S0092-8674(00)80903-4 }}
*{{cite journal | author=Nagulapalli S, Pongubala JM, Atchison ML |title=Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3). |journal=J. Immunol. |volume=155 |issue= 9 |pages= 4330-8 |year= 1995 |pmid= 7594592 |doi=  }}
* {{cite journal | vauthors = Dyer MA, Hayes PJ, Baron MH | title = The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. | journal = Mol. Cell. Biol. | volume = 18 | issue = 5 | pages = 2617–28 | year = 1998 | pmid = 9566881 | pmc = 110641 | doi =  }}
*{{cite journal | author=Orphanides G, LeRoy G, Chang CH, ''et al.'' |title=FACT, a factor that facilitates transcript elongation through nucleosomes. |journal=Cell |volume=92 |issue= 1 |pages= 105-16 |year= 1998 |pmid= 9489704 |doi= }}
* {{cite journal | vauthors = LeRoy G, Orphanides G, Lane WS, Reinberg D | title = Requirement of RSF and FACT for transcription of chromatin templates in vitro. | journal = Science | volume = 282 | issue = 5395 | pages = 1900–4 | year = 1998 | pmid = 9836642 | doi = 10.1126/science.282.5395.1900 }}
*{{cite journal | author=Dyer MA, Hayes PJ, Baron MH |title=The HMG domain protein SSRP1/PREIIBF is involved in activation of the human embryonic beta-like globin gene. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2617-28 |year= 1998 |pmid= 9566881 |doi=  }}
* {{cite journal | vauthors = Kelley DE, Stokes DG, Perry RP | title = CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. | journal = Chromosoma | volume = 108 | issue = 1 | pages = 10–25 | year = 1999 | pmid = 10199952 | doi = 10.1007/s004120050347 }}
*{{cite journal | author=LeRoy G, Orphanides G, Lane WS, Reinberg D |title=Requirement of RSF and FACT for transcription of chromatin templates in vitro. |journal=Science |volume=282 |issue= 5395 |pages= 1900-4 |year= 1998 |pmid= 9836642 |doi= }}
* {{cite journal | vauthors = Spencer JA, Baron MH, Olson EN | title = Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. | journal = J. Biol. Chem. | volume = 274 | issue = 22 | pages = 15686–93 | year = 1999 | pmid = 10336466 | doi = 10.1074/jbc.274.22.15686 }}
*{{cite journal | author=Kelley DE, Stokes DG, Perry RP |title=CHD1 interacts with SSRP1 and depends on both its chromodomain and its ATPase/helicase-like domain for proper association with chromatin. |journal=Chromosoma |volume=108 |issue= 1 |pages= 10-25 |year= 1999 |pmid= 10199952 |doi= }}
* {{cite journal | vauthors = Orphanides G, Wu WH, Lane WS, Hampsey M, Reinberg D | title = The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. | journal = Nature | volume = 400 | issue = 6741 | pages = 284–8 | year = 1999 | pmid = 10421373 | doi = 10.1038/22350 }}
*{{cite journal | author=Spencer JA, Baron MH, Olson EN |title=Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15686-93 |year= 1999 |pmid= 10336466 |doi= }}
* {{cite journal | vauthors = Wada T, Orphanides G, Hasegawa J, Kim DK, Shima D, Yamaguchi Y, Fukuda A, Hisatake K, Oh S, Reinberg D, Handa H | title = FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. | journal = Mol. Cell | volume = 5 | issue = 6 | pages = 1067–72 | year = 2000 | pmid = 10912001 | doi = 10.1016/S1097-2765(00)80272-5 }}
*{{cite journal | author=Orphanides G, Wu WH, Lane WS, ''et al.'' |title=The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins. |journal=Nature |volume=400 |issue= 6741 |pages= 284-8 |year= 1999 |pmid= 10421373 |doi= 10.1038/22350 }}
* {{cite journal | vauthors = Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H | title = A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. | journal = Mol. Cell | volume = 7 | issue = 2 | pages = 283–92 | year = 2001 | pmid = 11239457 | doi = 10.1016/S1097-2765(01)00176-9 }}
*{{cite journal | author=Wada T, Orphanides G, Hasegawa J, ''et al.'' |title=FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. |journal=Mol. Cell |volume=5 |issue= 6 |pages= 1067-72 |year= 2000 |pmid= 10912001 |doi= }}
* {{cite journal | vauthors = Yarnell AT, Oh S, Reinberg D, Lippard SJ | title = Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. | journal = J. Biol. Chem. | volume = 276 | issue = 28 | pages = 25736–41 | year = 2001 | pmid = 11344167 | doi = 10.1074/jbc.M101208200 }}
*{{cite journal | author=Keller DM, Zeng X, Wang Y, ''et al.'' |title=A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. |journal=Mol. Cell |volume=7 |issue= 2 |pages= 283-92 |year= 2001 |pmid= 11239457 |doi= }}
* {{cite journal | vauthors = Santoro P, De Andrea M, Migliaretti G, Trapani C, Landolfo S, Gariglio M | title = High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases. | journal = J. Rheumatol. | volume = 29 | issue = 1 | pages = 90–3 | year = 2002 | pmid = 11824977 | doi =  }}
*{{cite journal | author=Yarnell AT, Oh S, Reinberg D, Lippard SJ |title=Interaction of FACT, SSRP1, and the high mobility group (HMG) domain of SSRP1 with DNA damaged by the anticancer drug cisplatin. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 25736-41 |year= 2001 |pmid= 11344167 |doi= 10.1074/jbc.M101208200 }}
* {{cite journal | vauthors = Roig J, Mikhailov A, Belham C, Avruch J | title = Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. | journal = Genes Dev. | volume = 16 | issue = 13 | pages = 1640–58 | year = 2002 | pmid = 12101123 | pmc = 186374 | doi = 10.1101/gad.972202 }}
*{{cite journal | author=Santoro P, De Andrea M, Migliaretti G, ''et al.'' |title=High prevalence of autoantibodies against the nuclear high mobility group (HMG) protein SSRP1 in sera from patients with systemic lupus erythematosus, but not other rheumatic diseases. |journal=J. Rheumatol. |volume=29 |issue= 1 |pages= 90-3 |year= 2002 |pmid= 11824977 |doi=  }}
* {{cite journal | vauthors = Zeng SX, Dai MS, Keller DM, Lu H | title = SSRP1 functions as a co-activator of the transcriptional activator p63. | journal = EMBO J. | volume = 21 | issue = 20 | pages = 5487–97 | year = 2002 | pmid = 12374749 | pmc = 129072 | doi = 10.1093/emboj/cdf540 }}
*{{cite journal | author=Roig J, Mikhailov A, Belham C, Avruch J |title=Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. |journal=Genes Dev. |volume=16 |issue= 13 |pages= 1640-58 |year= 2002 |pmid= 12101123 |doi= 10.1101/gad.972202 }}
* {{cite journal | vauthors = Keller DM, Lu H | title = p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 50206–13 | year = 2003 | pmid = 12393879 | doi = 10.1074/jbc.M209820200 }}
*{{cite journal | author=Zeng SX, Dai MS, Keller DM, Lu H |title=SSRP1 functions as a co-activator of the transcriptional activator p63. |journal=EMBO J. |volume=21 |issue= 20 |pages= 5487-97 |year= 2002 |pmid= 12374749 |doi= }}
* {{cite journal | vauthors = Belotserkovskaya R, Oh S, Bondarenko VA, Orphanides G, Studitsky VM, Reinberg D | title = FACT facilitates transcription-dependent nucleosome alteration. | journal = Science | volume = 301 | issue = 5636 | pages = 1090–3 | year = 2003 | pmid = 12934006 | doi = 10.1126/science.1085703 }}
*{{cite journal | author=Keller DM, Lu H |title=p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 50206-13 |year= 2003 |pmid= 12393879 |doi= 10.1074/jbc.M209820200 }}
* {{cite journal | vauthors = Li J, Hawkins IC, Harvey CD, Jennings JL, Link AJ, Patton JG | title = Regulation of alternative splicing by SRrp86 and its interacting proteins. | journal = Mol. Cell. Biol. | volume = 23 | issue = 21 | pages = 7437–47 | year = 2003 | pmid = 14559993 | pmc = 207616 | doi = 10.1128/MCB.23.21.7437-7447.2003 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tan BC, Lee SC | title = Nek9, a novel FACT-associated protein, modulates interphase progression. | journal = J. Biol. Chem. | volume = 279 | issue = 10 | pages = 9321–30 | year = 2004 | pmid = 14660563 | doi = 10.1074/jbc.M311477200 }}
*{{cite journal | author=Belotserkovskaya R, Oh S, Bondarenko VA, ''et al.'' |title=FACT facilitates transcription-dependent nucleosome alteration. |journal=Science |volume=301 |issue= 5636 |pages= 1090-3 |year= 2003 |pmid= 12934006 |doi= 10.1126/science.1085703 }}
*{{cite journal  | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi=  }}
*{{cite journal | author=Tan BC, Lee SC |title=Nek9, a novel FACT-associated protein, modulates interphase progression. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 9321-30 |year= 2004 |pmid= 14660563 |doi= 10.1074/jbc.M311477200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|SSRP1+protein,+human}}
* {{MeshName|SSRP1+protein,+human}}


{{NLM content}}
{{Transcription factors|g4}}


{{protein-stub}}
{{NLM content}}
{{Transcription factors}}
[[Category:Transcription factors]]
[[Category:Transcription factors]]
{{gene-11-stub}}

Latest revision as of 06:34, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

FACT complex subunit SSRP1 also known as structure specific recognition protein 1 is a protein that in humans is encoded by the SSRP1 gene.[1]

Function

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.[1]

Interactions

Structure specific recognition protein 1 has been shown to interact with NEK9.[2] SSRP1 further interacts with transcriptional activator p63.[3] SSRP1 enhances the activity of full-length p63, but it has no effect on the N-terminus-deleted p63 (DeltaN-p63) variant.

References

  1. ↑ 1.0 1.1 "Entrez Gene: SSRP1 structure specific recognition protein 1".
  2. ↑ Tan BC, Lee SC (Mar 2004). "Nek9, a novel FACT-associated protein, modulates interphase progression". J. Biol. Chem. 279 (10): 9321–30. doi:10.1074/jbc.M311477200. PMID 14660563.
  3. ↑ Zeng SX, Dai MS, Keller DM, Lu H (15 Oct 2002). "SSRP1 functions as a co-activator of the transcriptional activator p63". EMBO J. 21 (20): 5487–97. doi:10.1093/emboj/cdf540. PMC 129072. PMID 12374749.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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