Small-sized vessel vasculitis with fever, headache, weight loss, arthralgia, and claudication: Difference between revisions

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(Created page with "__NOTOC__ {{CMG}}; {{AE}} {{EG}} <span style="font-size:85%">'''Abbreviations:''' ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptid...")
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__NOTOC__
__NOTOC__
{{CMG}}; {{AE}} {{EG}}
{{CMG}}; {{AE}} {{EG}}


<span style="font-size:85%">'''Abbreviations:'''
<span style="font-size:85%">'''Abbreviations:'''
ABG= [[Arterial blood gas]], ANA= [[Antinuclear antibody]], ANP= [[Atrial natriuretic peptide]], ASO= [[Antistreptolysin O|Antistreptolysin O antibody]], BNP= [[Brain natriuretic peptide]], CBC= [[Complete blood count]], COPD= [[Chronic obstructive pulmonary disease]], CRP= [[C-reactive protein]], CT= [[Computed tomography]], CXR= [[Chest X-ray]], DVT= [[Deep vein thrombosis]], ESR= [[Erythrocyte sedimentation rate]], HRCT= [[High Resolution CT]], IgE= [[Immunoglobulin E]], LDH= [[Lactate dehydrogenase]], PCWP= [[Pulmonary capillary wedge pressure]], PCR= [[Polymerase chain reaction]], PFT= [[Pulmonary function test]].</span>
ABG= [[Arterial blood gas]], ANA= [[Antinuclear antibody]], ANP= [[Atrial natriuretic peptide]], ASO= [[Antistreptolysin O|Antistreptolysin O antibody]], BNP= [[Brain natriuretic peptide]], CBC= [[Complete blood count]], COPD= [[Chronic obstructive pulmonary disease]], CRP= [[C-reactive protein]], CT= [[Computed tomography]], CXR= [[Chest X-ray]], DVT= [[Deep vein thrombosis]], ESR= [[Erythrocyte sedimentation rate]], HRCT= [[High Resolution CT]], IgE= [[Immunoglobulin E]], LDH= [[Lactate dehydrogenase]], PCWP= [[Pulmonary capillary wedge pressure]], PCR= [[Polymerase chain reaction]], PFT= [[Pulmonary function test]].</span>
<small><small>
{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
{| style="border: 0px; font-size: 90%; margin: 3px;" align="center"
! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
! colspan="3" rowspan="4" style="background:#4479BA; color: #FFFFFF;" align="center" |Diseases
Line 35: Line 37:
! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
! style="background:#4479BA; color: #FFFFFF;" align="center" |Other
|-
|-
! rowspan="30" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |Small-Vessel Vasculitis
! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[ANCA-associated vasculitis]]
! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hematologic disease]]
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Microscopic polyangiitis]]<ref name="pmid20688249">{{cite journal| author=Chung SA, Seo P| title=Microscopic polyangiitis. | journal=Rheum Dis Clin North Am | year= 2010 | volume= 36 | issue= 3 | pages= 545-58 | pmid=20688249 | doi=10.1016/j.rdc.2010.04.003 | pmc=2917831 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20688249  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (40%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (60%)
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normocytic anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Proteinuria]], [[RBC casts|Erythrocyte casts]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Suspected [[pancreatitis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric]] [[angiography]] for differentiating from [[polyarteritis nodosa]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral nodular, and patchy [[Opacity|opacities]] in [[Chest X-ray|CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Glomerulonephritis]] with focal [[necrosis]], crescent formation, and lack or paucity of [[immunoglobulin]] deposits
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rash]], [[Hemoptysis]] 
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Granulomatosis with polyangiitis|Granulomatosis with polyangiitis (Wegener’s)]]<ref name="pmid27195187">{{cite journal| author=Kubaisi B, Abu Samra K, Foster CS| title=Granulomatosis with polyangiitis (Wegener's disease): An updated review of ocular disease manifestations. | journal=Intractable Rare Dis Res | year= 2016 | volume= 5 | issue= 2 | pages= 61-9 | pmid=27195187 | doi=10.5582/irdr.2016.01014 | pmc=4869584 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27195187  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C-ANCA|Anti-PR3 antibody (C-ANCA)]] (90%), [[P-ANCA|Anti-MPO antibody (P-ANCA)]] (10%)
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Normochromic anemia|Normochromic normocytic anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Consolidation (medicine)|Consolidation]], Patchy or diffuse [[Ground glass opacification on CT|ground-glass opacities]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occlusion]] or [[stenosis]] of [[LAD]] and [[RCA]] in [[coronary angiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Single or multiple [[nodules]] and [[Mass|masses]] with [[cavitation]] in [[CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Parenchymal]] [[necrosis]], [[Granulomatous]] [[inflammation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Conjunctivitis]],
 
[[Episcleritis]],
 
[[Uveitis]],
 
[[Optic nerve]] vasculitis
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Eosinophilic granulomatosis with polyangiitis|Eosinophilic granulomatosis with polyangiitis]]
[[Eosinophilic granulomatosis with polyangiitis|(Churg-Strauss)]]<ref name="pmid16612766">{{cite journal |vauthors=Keogh KA, Specks U |title=Churg-Strauss syndrome |journal=Semin Respir Crit Care Med |volume=27 |issue=2 |pages=148–57 |date=April 2006 |pmid=16612766 |doi=10.1055/s-2006-939518 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]] (40%), Eotaxin-3
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]], [[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Proteinuria]], [[RBC casts|Erythrocyte casts]], ↑[[Immunoglobulin E|IgE]] levels
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Significant enlargement of peripheral [[pulmonary arteries]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Myocardial ischemia]] and [[Myocardial infarction|infarction]] in [[coronary angiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Congestive heart failure|Congestive heart failure (CHF)]] in [[echocardiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Extensive air-space [[Opacity|opacities]] in [[CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Small [[necrotizing]] [[granulomas]] with  [[eosinophilic]] core surrounded by [[macrophages]] and [[Epithelioid cell|epithelioid giant cells]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Allergic rhinitis]], [[Asthma]], [[Urticaria|Urticarial rash]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hydralazine]]-associated [[ANCA-associated vasculitis]]<ref name="pmid23316942">{{cite journal| author=Keasberry J, Frazier J, Isbel NM, Van Eps CL, Oliver K, Mudge DW| title=Hydralazine-induced anti-neutrophil cytoplasmic antibody-positive renal vasculitis presenting with a vasculitic syndrome, acute nephritis and a puzzling skin rash: a case report. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue=  | pages= 20 | pmid=23316942 | doi=10.1186/1752-1947-7-20 | pmc=3565908 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23316942  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[P-ANCA|Anti-MPO antibody (P-ANCA)]], Anti-histone antibodies
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Creatinine|Cr]] or [[Blood urea nitrogen|BUN]], [[Hypoalbuminemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[pulmonary]] infiltrates
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aneurysms]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Pauci-immune [[necrotizing]] and [[crescentic glomerulonephritis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sinusitis]], [[Hemoptysis]]
|-
! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Immune complexes|Immune complex]] small-vessel vasculitis
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Goodpasture disease|Anti-glomerular basement membrane disease]]<ref name="pmid28515156">{{cite journal |vauthors=McAdoo SP, Pusey CD |title=Anti-Glomerular Basement Membrane Disease |journal=Clin J Am Soc Nephrol |volume=12 |issue=7 |pages=1162–1172 |date=July 2017 |pmid=28515156 |doi=10.2215/CJN.01380217 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypochromic anemia|Hypochromic microcytic anemia]], [[Thrombocytopenia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C3 (complement)|C3]] level
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary hemorrhage]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal [[kidneys]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Alveolar]] infiltrates spreading from the [[hilum]] in [[CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Cellular crescents in the [[glomeruli]], [[Pulmonary hemorrhage|Intra-alveolar hemorrhages]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anti-GBM antibody|Anti-GBM antibodies]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hemoptysis]], [[Hematuria]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cryoglobulinemia|Cryoglobulinemic vasculitis]]<ref name="pmid16344620">{{cite journal |vauthors=Ferri C, Mascia MT |title=Cryoglobulinemic vasculitis |journal=Curr Opin Rheumatol |volume=18 |issue=1 |pages=54–63 |date=January 2006 |pmid=16344620 |doi= |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C4A|C4 component]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], [[hypocomplementemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O underlying [[malignancy]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Stenosis]] or [[Occlusion|occlusions]] of the [[Visceral|visceral arteries]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bacterial endocarditis]] in [[echocardiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Interstitial]] involvement or [[pleural effusions]] in [[CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HCV]]-associated [[proteins]] in [[vasculitic]] [[skin]], Intraluminal [[cryoglobulin]] deposits 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Acrocyanosis]], [[Retinal]] [[hemorrhage]], [[Purpura]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hepatitis C virus]]-associated [[Cryoglobulinemia|cryoglobulinemic vasculitis]]<ref name="pmid28810602">{{cite journal| author=Guo QY, Wu M, Wang YW, Sun GD| title=Hepatitis C virus-associated cryoglobulinemia with membrano-proliferative glomerulonephritis treated with prednisolone and interferon: A case report. | journal=Exp Ther Med | year= 2017 | volume= 14 | issue= 2 | pages= 1395-1398 | pmid=28810602 | doi=10.3892/etm.2017.4671 | pmc=5525644 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28810602  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Cryoglobulins]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↓[[C4A|Serum C4]], Positive [[RF]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[hepatic]] [[echogenicity]] in [[MRI]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vasculitic]] skin, [[Antigen]] infilteration in [[lesions]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatitis C|HCV RNA]], [[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Palpable [[purpura]], [[Microscopic hematuria]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Henoch-Schönlein purpura|IgA vasculitis (Henoch-Schönlein purpura)]]<ref name="pmid26990342">{{cite journal |vauthors=Farhadian JA, Castilla C, Shvartsbeyn M, Meehan SA, Neimann A, Pomeranz MK |title=IgA vasculitis (Henoch-Schönlein purpura) |journal=Dermatol. Online J. |volume=21 |issue=12 |pages= |date=December 2015 |pmid=26990342 |doi= |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgA]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia]], [[Leukocytosis]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Occult blood|Stool OB]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased [[bowel]] wall thickness, [[Hematoma|hematomas]], [[peritoneal fluid]], and [[intussusception]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Dilated loops of [[bowel]] consistent in [[abdominal X-ray]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytoclastic vasculitis]] in postcapillary [[venules]] with [[IgA]] deposition
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Purpura|Palpable purpura]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypocomplementemia|Hypocomplementemic urticarial vasculitis (anti-C1q vasculitis)]]<ref name="pmid22328958">{{cite journal| author=Buck A, Christensen J, McCarty M| title=Hypocomplementemic urticarial vasculitis syndrome: a case report and literature review. | journal=J Clin Aesthet Dermatol | year= 2012 | volume= 5 | issue= 1 | pages= 36-46 | pmid=22328958 | doi= | pmc=3277093 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22328958  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C11orf1|C1q]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antinuclear antibodies|ANA]], ↓[[C10orf10|C1q]], ↓[[C3 (complement)|C3]], ↓[[C4A|C4]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Deposits of [[immunoglobulins]], [[complement]], or [[fibrin]] around [[blood vessels]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]],
 
[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Urticaria]], [[Hematuria]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Gastrointestinal diseases|Gastrointestinal disease]]
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute mesenteric ischemia]]<ref name="pmid24267504">{{cite journal |vauthors=Sise MJ |title=Acute mesenteric ischemia |journal=Surg. Clin. North Am. |volume=94 |issue=1 |pages=165–81 |date=February 2014 |pmid=24267504 |doi=10.1016/j.suc.2013.10.012 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FABP1|I-FABP]], [[GSTA1|Alpha-GST]], [[Ischemia-modified albumin (IMA)]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], ↑[[Hematocrit|HCT]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" | ↑[[Amylase]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bowel]] wall thickening, [[Pneumatosis intestinalis|Intestinal pneumatosis]], [[Mesenteric ischemia|Portomesenteric]] thrombosis
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Mesenteric vein thrombosis|Mesenteric venous thrombosis]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Artery|Arterial]] [[stenosis]] or occlusion of the [[Celiac artery|celiac]] or [[superior mesenteric arteries]] in [[duplex ultrasound]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ileus]] with distended loops of [[bowel]], [[Bowel]] wall thickening in [[abdominal X-ray]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Superficial [[Mucosal bleeding|mucosal hemorrhage]], [[edema]] and [[necrosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |History and [[physical examination]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Abdominal pain]], [[Distension]], [[Absent bowel sounds]]
|-
! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Cardiovascular diseases|Cardiovascular disease]]
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Infective Endocarditis]]<ref name="pmid19665088">{{cite journal| author=McDonald JR| title=Acute infective endocarditis. | journal=Infect Dis Clin North Am | year= 2009 | volume= 23 | issue= 3 | pages= 643-64 | pmid=19665088 | doi=10.1016/j.idc.2009.04.013 | pmc=2726828 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19665088  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[NT-proBNP]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Normochromic anemia|Normochromic-normocytic anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypergammaglobulinemia|Hyperglobulinemia]], [[Cryoglobulinemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Metastatic]] [[infections]], such as [[Splenic infarction|splenic infarct]], [[Renal infarct|renal infarcts]], or [[psoas abscess]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]], [[abscess]], or new dehiscence of a [[Prosthetic valves|prosthetic valve]]<nowiki/>in [[echocardiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vertebral osteomyelitis]] in [[Magnetic resonance imaging|MRI]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vegetation (pathology)|Vegetation]] or [[Abscess|intracardiac abscess]] demonstrating active [[endocarditis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Echocardiography]] ([[TTE]])
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Janeway lesions]], [[Osler nodes]], [[Roth's spot|Roth spots]], [[Vertebral osteomyelitis]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Leukocytoclastic vasculitis|Leukocytoclastic Vasculitis]]<ref name="pmid26176572">{{cite journal| author=Einhorn J, Levis JT| title=Dermatologic Diagnosis: Leukocytoclastic Vasculitis. | journal=Perm J | year= 2015 | volume= 19 | issue= 3 | pages= 77-8 | pmid=26176572 | doi=10.7812/TPP/15-001 | pmc=4500485 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26176572  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgM]], [[IgA]], [[Immunoglobulin G|IgG]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Vascular]] [[stenosis]] and [[obstruction]] in visceral [[Angiogram|angiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Perivascular [[inflammatory]] infiltrate of [[neutrophils]] with leukocytoclasia (releasing [[nuclear]] debris)
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Purpura|Palpable purpura]], [[Petechiae]] 
|-
! rowspan="4" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary disease]]
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Langerhans Cell Histiocytosis]]<ref name="pmid18572052">{{cite journal |vauthors=Margo CE, Goldman DR |title=Langerhans cell histiocytosis |journal=Surv Ophthalmol |volume=53 |issue=4 |pages=332–58 |date=2008 |pmid=18572052 |doi=10.1016/j.survophthal.2008.04.007 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[CD1a]], CD207,[[BRAF (gene)|BRAF-V600E]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary cystic lymphangiectasis|Pulmonary cysts]] and [[Pulmonary nodule|nodules]], [[Lytic|Bone lytic lesions]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatomegaly]], [[Splenomegaly]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebellum]] and [[pons]] hyperintensity in [[MRI]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Birbeck granules]] by [[electron microscopy]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Brown to purplish [[papules]], [[Eczematous Scaling|Eczematous rash]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non small cell lung cancer|Non-Small Cell Lung Cancer]]<ref name="pmid18452692">{{cite journal| author=Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA| title=Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. | journal=Mayo Clin Proc | year= 2008 | volume= 83 | issue= 5 | pages= 584-94 | pmid=18452692 | doi=10.4065/83.5.584 | pmc=2718421 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18452692  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[EGFR]], ''[[ROS1]],'' [[Anaplastic lymphoma kinase|EML4-''ALK'']],  [[PD-L1]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypercalcemia]], [[Hyponatremia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary|Pulmonary lesion]] or [[mass]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] marginal [[lesions]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cancer staging|Staging]] and response to treatment in [[Positron emission tomography|PET-CT]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Adenocarcinoma of the lung pathophysiology|Adenocarcinoma]], [[Squamous cell carcinoma of the lung pathophysiology|Squamous cell carcinoma]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Small cell lung cancer|Small Cell Lung Cancer]]<ref name="pmid16226617">{{cite journal |vauthors=Jackman DM, Johnson BE |title=Small-cell lung cancer |journal=Lancet |volume=366 |issue=9494 |pages=1385–96 |date=2005 |pmid=16226617 |doi=10.1016/S0140-6736(05)67569-1 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |''[[P53 (protein)|p53]],'' [[Thyroid transcription factor-1|Thyroid transcription factor-1 (TTF1)]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hyponatremia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Large [[hilar]] mass with bulky [[mediastinal]] [[adenopathy]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Endobronchial [[ultrasound]] (EBUS)
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Standard [[Staging (pathology)|staging]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Spindled cells with dark [[nuclei]], scant [[cytoplasm]], and fine, granular [[Chromatin|nuclear chromatin]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Computed tomography|High resolution CT-scan]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Pulmonary Infarction]]<ref name="pmid15821192">{{cite journal |vauthors=Parambil JG, Savci CD, Tazelaar HD, Ryu JH |title=Causes and presenting features of pulmonary infarctions in 43 cases identified by surgical lung biopsy |journal=Chest |volume=127 |issue=4 |pages=1178–83 |date=April 2005 |pmid=15821192 |doi=10.1378/chest.127.4.1178 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[D-dimer]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[leukocytosis]], Mild [[anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypoxemia]], [[Hypocarbia]] or [[Hypercarbia]],  [[Respiratory alkalosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary embolism]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Low-[[density]] filling defect within the [[pulmonary artery]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pericardial effusion]] in [[echocardiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary]] infiltrates, [[atelectasis]], and [[pleural effusions]] in [[Chest X-ray|CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Infarct]] induced [[apoptosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pulmonary artery]] [[angiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Hemoptysis]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Renal disease]]
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Acute poststreptococcal glomerulonephritis|Acute Poststreptococcal Glomerulonephritis]]<ref name="pmid25554106">{{cite journal |vauthors=VanDeVoorde RG |title=Acute poststreptococcal glomerulonephritis: the most common acute glomerulonephritis |journal=Pediatr Rev |volume=36 |issue=1 |pages=3–12; quiz 13 |date=January 2015 |pmid=25554106 |doi=10.1542/pir.36-1-3 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Antistreptococcal antibodies|Antistreptolysin-O (ASO) titers]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hypocomplementemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Normal to slightly enlarged [[kidneys]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Central venous pressure|Central venous]] congestion in a [[hilar]] pattern  in [[Chest X-ray|CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypercellularity of [[Endothelial cells|endothelial]] and [[mesangial cells]], Infiltration of the [[glomerular]] tuft with [[polymorphonuclear cells]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]]
|-
! rowspan="8" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hematologic disease]]
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hemolytic-uremic syndrome|Hemolytic-Uremic Syndrome]]<ref name="pmid11691946">{{cite journal |vauthors=Corrigan JJ, Boineau FG |title=Hemolytic-uremic syndrome |journal=Pediatr Rev |volume=22 |issue=11 |pages=365–9 |date=November 2001 |pmid=11691946 |doi= |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[C5a|C5b-9]], [[ADAMTS13]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Reticulocytosis]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Lactate dehydrogenase|Lactate dehydrogenase (LDH)]], [[Hypercalcemia]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thalami]], [[brainstem]], or [[cerebellum]] abnormality
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cerebral]] [[microangiopathy]] or [[hypertension]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Hypoechoic [[kidney]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Abnormal hyperintensity in the [[Brain|brain cisterns]] in [[MRI]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thromboses|Microthromboses]] include [[Fibrin|fibrin thrombi]] that may occlude the [[glomerular]] tuft
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Proteinuria]] 
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia (CLL)]]<ref name="pmid15561682">{{cite journal |vauthors=Byrd JC, Stilgenbauer S, Flinn IW |title=Chronic lymphocytic leukemia |journal=Hematology Am Soc Hematol Educ Program |volume= |issue= |pages=163–83 |date=2004 |pmid=15561682 |doi=10.1182/asheducation-2004.1.163 |url=}}</ref>
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia (CLL)]]<ref name="pmid15561682">{{cite journal |vauthors=Byrd JC, Stilgenbauer S, Flinn IW |title=Chronic lymphocytic leukemia |journal=Hematology Am Soc Hematol Educ Program |volume= |issue= |pages=163–83 |date=2004 |pmid=15561682 |doi=10.1182/asheducation-2004.1.163 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
Line 450: Line 59:
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Chromosomal]] and [[genetic testing]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Chromosomal]] and [[genetic testing]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Multiple myeloma|Multiple Myeloma]]<ref name="pmid28318212">{{cite journal |vauthors=Michels TC, Petersen KE |title=Multiple Myeloma: Diagnosis and Treatment |journal=Am Fam Physician |volume=95 |issue=6 |pages=373–383 |date=March 2017 |pmid=28318212 |doi= |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Light chain|Ig light chain]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]], [[Leukopenia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Bone marrow aspiration]] and [[biopsy]], ↑[[Cr]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Osseous]] involvement and [[Lytic|lytic lesions]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Peripheral zone of increased [[vascularity]] in lesions
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Punched-out lesion in [[X-ray|skull X-ray]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clonal proliferation of [[plasma cells]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Protein electrophoresis]] plus conventional [[X-rays]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Constipation]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Hypereosinophilic syndrome|Hypereosinophilic Syndrome]]<ref name="pmid19630574">{{cite journal |vauthors=Klion A |title=Hypereosinophilic syndrome: current approach to diagnosis and treatment |journal=Annu. Rev. Med. |volume=60 |issue= |pages=293–306 |date=2009 |pmid=19630574 |doi=10.1146/annurev.med.60.062107.090340 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IgE]], [[CD117]] with [[CD2]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Eosinophilia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑Serum [[tryptase]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Lymphadenopathy]] and [[splenomegaly]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracardiac thrombus|Intracardiac thrombi]] in [[echocardiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Reticulin|Reticulin stain]] for [[myelofibrosis]] and [[tryptase]] staining for [[mast cells]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Splinter hemorrhages]], [[Raynaud phenomenon]]
|-
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non-Hodgkin lymphoma|Non-Hodgkin Lymphoma]]<ref name="pmid22835603">{{cite journal |vauthors=Shankland KR, Armitage JO, Hancock BW |title=Non-Hodgkin lymphoma |journal=Lancet |volume=380 |issue=9844 |pages=848–57 |date=September 2012 |pmid=22835603 |doi=10.1016/S0140-6736(12)60605-9 |url=}}</ref>
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Non-Hodgkin lymphoma|Non-Hodgkin Lymphoma]]<ref name="pmid22835603">{{cite journal |vauthors=Shankland KR, Armitage JO, Hancock BW |title=Non-Hodgkin lymphoma |journal=Lancet |volume=380 |issue=9844 |pages=848–57 |date=September 2012 |pmid=22835603 |doi=10.1016/S0140-6736(12)60605-9 |url=}}</ref>
Line 514: Line 81:
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Testicular mass]], [[Skin lesions|Skin lesion]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Testicular mass]], [[Skin lesions|Skin lesion]]
|-
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Serum sickness|Serum Sickness]]<ref name="pmid2867672">{{cite journal |vauthors=Lin RY |title=Serum sickness syndrome |journal=Am Fam Physician |volume=33 |issue=1 |pages=157–62 |date=January 1986 |pmid=2867672 |doi= |url=}}</ref>
! rowspan="2" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic lupus erythematosus]]<ref name="Tsokos2011">{{cite journal|last1=Tsokos|first1=George C.|title=Systemic Lupus Erythematosus|journal=New England Journal of Medicine|volume=365|issue=22|year=2011|pages=2110–2121|issn=0028-4793|doi=10.1056/NEJMra1100359}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[IL-1]], [[IL-6]], [[TNF]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukopenia]] 
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Gammopathy|Polyclonal gammopathy]], ↑[[Cr]], [[Cryoglobulinemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Arteritic lesions are focal, [[necrotizing]], and [[inflammatory]]  involving all layers of the [[artery]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hematuria]], [[Skin rash]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Disseminated intravascular coagulation|Disseminated Intravascular Coagulation]]<ref name="pmid25535423">{{cite journal| author=Venugopal A| title=Disseminated intravascular coagulation. | journal=Indian J Anaesth | year= 2014 | volume= 58 | issue= 5 | pages= 603-8 | pmid=25535423 | doi=10.4103/0019-5049.144666 | pmc=4260307 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25535423  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Fibrin degradation product|Fibrin degradation product (FDP)]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Thrombocytopenia]], [[Schistocytes]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[aPTT]] and [[PT]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Intracranial hemorrhage]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ischemia]] and [[necrosis]] due to [[Fibrin|fibrin deposition]] in small and medium-sized [[vessels]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[Medical laboratory|laboratory abnormalities]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[Cyanosis|Acral cyanosis]], [[Hemorrhagic]] skin [[Infarction|infarctions]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Idiopathic thrombocytopenic purpura|Idiopathic Thrombocytopenic Purpura]]<ref name="pmid27441004">{{cite journal| author=Nomura S| title=Advances in Diagnosis and Treatments for Immune Thrombocytopenia. | journal=Clin Med Insights Blood Disord | year= 2016 | volume= 9 | issue=  | pages= 15-22 | pmid=27441004 | doi=10.4137/CMBD.S39643 | pmc=4948655 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27441004  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[FCGR2B|FC gamma receptors (FCGR) IIb]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Anemia]], [[Thrombocytopenia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[HIV]], [[ANA]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O other causes
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |R/O [[splenomegaly]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Increased number of normal morphologic [[megakaryocytes]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with [[thrombocytopenia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Easy bruising]], [[Purpura]]
|-
! rowspan="5" style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic disease]]
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Sarcoidosis]]<ref name="pmid27454074">{{cite journal| author=Chiarchiaro J, Chen BB, Gibson KF| title=New molecular targets for the treatment of sarcoidosis. | journal=Curr Opin Pulm Med | year= 2016 | volume= 22 | issue= 5 | pages= 515-21 | pmid=27454074 | doi=10.1097/MCP.0000000000000304 | pmc=5152532 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27454074  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" | [[IL-2]] and [[Interferon gamma|IFN-γ]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Mild [[anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[Angiotensin-converting enzyme|ACE]], ↑[[Vitamin D|1, 25-dihydroxyvitamin D]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Active [[alveolitis]] or [[fibrosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Hepatosplenomegaly]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Bilateral [[Adenopathy|hilar adenopathy]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Granuloma|Noncaseating granulomas (NCGs)]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Histopathology|Histological confirmation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Heart block]], [[Ocular disease|Ocular lesion]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Legionella Infections|Legionella Infection]]<ref name="pmid12491204">{{cite journal |vauthors=Murdoch DR |title=Diagnosis of Legionella infection |journal=Clin. Infect. Dis. |volume=36 |issue=1 |pages=64–9 |date=January 2003 |pmid=12491204 |doi=10.1086/345529 |url=}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cytokine|Inflammatory cytokines]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]] with [[left shift]], [[Thrombocytosis]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |↑[[D-dimer]], [[Fibrin degradation product|FDP]], [[Hyponatremia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Pleural effusion]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Nonspecific and indistinguishable [[CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Intra-[[alveolar]] [[inflammation]], [[Abscesses|Microabscesses]] in the [[parenchyma]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Sputum culture]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cough]], [[Diarrhea]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Systemic lupus erythematosus]]<ref name="Tsokos2011">{{cite journal|last1=Tsokos|first1=George C.|title=Systemic Lupus Erythematosus|journal=New England Journal of Medicine|volume=365|issue=22|year=2011|pages=2110–2121|issn=0028-4793|doi=10.1056/NEJMra1100359}}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
Line 643: Line 105:
|-
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rheumatoid arthritis]]<ref name="pmid16824912">{{cite journal| author=Scott JT| title=The gold standard in rheumatoid arthritis. | journal=J R Soc Med | year= 1991 | volume= 84 | issue= 9 | pages= 513-4 | pmid=1682491 | doi= | pmc=1293405 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1682491  }}</ref>
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Rheumatoid arthritis]]<ref name="pmid16824912">{{cite journal| author=Scott JT| title=The gold standard in rheumatoid arthritis. | journal=J R Soc Med | year= 1991 | volume= 84 | issue= 9 | pages= 513-4 | pmid=1682491 | doi= | pmc=1293405 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1682491  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
Line 663: Line 125:
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled [[Anti-citrullinated protein antibody|anti-CCP antibody]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled [[Anti-citrullinated protein antibody|anti-CCP antibody]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid nodules]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Rheumatoid nodules]]
|-
! style="padding: 5px 5px; background: #DCDCDC;" align="center" |[[Relapsing polychondritis]]<ref name="pmid27708954">{{cite journal| author=Emmungil H, Aydın SZ| title=Relapsing polychondritis. | journal=Eur J Rheumatol | year= 2015 | volume= 2 | issue= 4 | pages= 155-159 | pmid=27708954 | doi=10.5152/eurjrheum.2015.0036 | pmc=5047229 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27708954  }}</ref>
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+/-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |+
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Leukocytosis]], [[Anemia]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |-
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Cryoglobulins]], [[ANA]], [[C-ANCA]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Calcification]] of [[Cartilaginous|cartilaginous structures]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Aortic root|Aortic root dilatation]] and degree of [[aortic regurgitation]] in [[echocardiography]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Tracheal stenosis]] in [[CXR]]
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Chondrolysis, [[Chondritis]],  Perichondritis
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |Clinical findings coupled with imaging
! style="padding: 5px 5px; background: #F5F5F5;" align="center" |[[Ear pain]] and redness, [[Polyarthritis]]
|-
|-
|}
|}
 
</small></small>
==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category: Medicine]]
[[Category: Up-To-Date]]
[[Category: Primary care]]
[[Category: Rheumatology]]
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[[Category:Medicine]]
[[Category:Up-To-Date]]
[[Category:Rheumatology]]

Latest revision as of 00:13, 30 July 2020


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

Abbreviations: ABG= Arterial blood gas, ANA= Antinuclear antibody, ANP= Atrial natriuretic peptide, ASO= Antistreptolysin O antibody, BNP= Brain natriuretic peptide, CBC= Complete blood count, COPD= Chronic obstructive pulmonary disease, CRP= C-reactive protein, CT= Computed tomography, CXR= Chest X-ray, DVT= Deep vein thrombosis, ESR= Erythrocyte sedimentation rate, HRCT= High Resolution CT, IgE= Immunoglobulin E, LDH= Lactate dehydrogenase, PCWP= Pulmonary capillary wedge pressure, PCR= Polymerase chain reaction, PFT= Pulmonary function test.

Diseases Clinical manifestations Para-clinical findings Gold standard Additional findings
Symptoms Physical examination
Lab Findings Imaging Histopathology
Headache Fever Weight loss Arthralgia Claudication Bruit HTN Focal neurological disorder Biomarker CBC ESR Other CT scan Angiography Ultrasound/ Echocardiography Other
Small-Vessel Vasculitis Hematologic disease Chronic Lymphocytic Leukemia (CLL)[1] + + + + +/- - - +/- CD5, CD19, CD20, IgVH Absolute lymphocytosis, Smudge cells ↑ Flow cytometry Staging - - - Large atypical cells, cleaved cells, and prolymphocytes  Chromosomal and genetic testing Easy bruising
Non-Hodgkin Lymphoma[2] + + + + +/- +/- +/- +/- MYC, BCL2, BCL6, and TP53 Lymphocytosis, Anemia, Thrombocytopenia ↑ ↑Lactate dehydrogenase (LDH), Hypercalcemia  Enlarged lymph nodes, Hepatosplenomegaly, Filling defects in the liver and spleen - Hepatosplenomegaly Mediastinal lymphadenopathy Small cleaved or noncleaved, intermediate, or large cell with a follicular or diffuse pattern Surgically excised tissue biopsy Easy bruising, Testicular mass, Skin lesion
Systemic disease Systemic lupus erythematosus[3] + + + + +/- - + + Anti dsDNA, ANA  Leukopenia, Lymphopenia, Anemia, Thrombocytopenia ↑ ↑Cr or BUN,

↑ALT or AST, Proteinuria

Interstitial lung disease, Pneumonitis, Pulmonary emboli, Alveolar hemorrhage Aneurysms Pericardial effusion, pulmonary hypertension, or verrucous Libman-Sacks endocarditis in echocardiography Central nervous system (CNS) lupus white-matter changes in MRI Staging lupus nephritis Anti-dsDNA antibody test Skin rashes or photosensitivity
Rheumatoid arthritis[4] +/- +/- + + + + - - RF, Anti-CCP antibody Anemia ↑ ↑Cr or BUN,

↑ALT or AST, ANA

Microfractures Aneurysms Effusions in joints Basilar invagination with cranial migration of an eroded odontoid peg in MRI Influx of inflammatory cells into the synovial membrane, with angiogenesis, proliferation of chronic inflammatory cells Clinical findings coupled anti-CCP antibody Rheumatoid nodules

References

  1. ↑ Byrd JC, Stilgenbauer S, Flinn IW (2004). "Chronic lymphocytic leukemia". Hematology Am Soc Hematol Educ Program: 163–83. doi:10.1182/asheducation-2004.1.163. PMID 15561682.
  2. ↑ Shankland KR, Armitage JO, Hancock BW (September 2012). "Non-Hodgkin lymphoma". Lancet. 380 (9844): 848–57. doi:10.1016/S0140-6736(12)60605-9. PMID 22835603.
  3. ↑ Tsokos, George C. (2011). "Systemic Lupus Erythematosus". New England Journal of Medicine. 365 (22): 2110–2121. doi:10.1056/NEJMra1100359. ISSN 0028-4793.
  4. ↑ Scott JT (1991). "The gold standard in rheumatoid arthritis". J R Soc Med. 84 (9): 513–4. PMC 1293405. PMID 1682491.

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