Sideroblastic anemia differential diagnosis: Difference between revisions

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Revision as of 17:55, 2 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

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Overview

Differential Diagnosis

Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.

• Tissue iron overload from sideroblastic anemia may act similar to hereditary hemochromatosis with liver cirrhosis, diabetes, congestive heart failure, and cardiac arrhythmias.

ALA Dehydratase Deficiency Porphyria
Acute Myeloid Leukemia (AML)
Congenital Erythropoietic Porphyria
Hereditary Coproporphyria
Iron Deficiency Anemia
Myelodysplastic Syndrome
Secondary Thrombocytosis

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

		Symptoms			Physical examination			Lab Findings
Diseases		Clinical manifestations						Para-clinical findings						Gold standard
		Symptoms			Physical examination			Para-clinical findings
		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Peripheral blood smear	Serum iron	Serum TIBC	Serum ferritin g/L	Iron in erythroblasts	Iron stores in bone marrow
	Sideroblastic anemia	Pallor	Weaknes					variable	Normal -high	Normal	50-300	present in ring form	present
Microcytic hypochromic anemia	Iron deficiency anemia	pallor	Jaundice					microcytic/ hypochromic	<30	> 360	<15	absent	absent
	Thalasemia	Jaundice	jaundice	irritibility	Hpatomegaly	Splenomegaly	Growth retardation	micro/hypo with targeting	Normal -high	Normal	50-300	present	present
	Anemia of chronic disease							Normal	Low	<300	30-200	absent	present
	Lead poisoning
	Blood loss
Diseases		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3				Gold standard
Tissue iron overload

References

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 ! colspan="2" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
 | colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
-! colspan="12" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
+! colspan="8" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
 | colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
-! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Additional findings
 |-
 | colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Symptoms'''
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 |-
 ! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
-! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
-! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
 |-
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Symptom 1
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 !Iron in erythroblasts
 !Iron stores in bone marrow
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 1
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 2
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 3
 |-
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 |Sideroblastic anemia
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+|Pallor
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+|Weaknes
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 |present in ring form
 |present
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 |Iron deficiency anemia
 | style="background: #F5F5F5; padding: 5px;" |pallor
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |Jaundice
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
@@ Line 91: / Line 80: @@
 |absent
 |absent
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
 |-
 |Thalasemia
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+[[Jaundice]]
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |jaundice
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |irritibility
+| style="background: #F5F5F5; padding: 5px;" |Hpatomegaly
+| style="background: #F5F5F5; padding: 5px;" |Splenomegaly
+| style="background: #F5F5F5; padding: 5px;" |Growth retardation
 | style="background: #F5F5F5; padding: 5px;" |micro/hypo with targeting
 | style="background: #F5F5F5; padding: 5px;" |Normal -high
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 |present
 |present
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 |absent
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 !
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-!Imaging 1
-!Imaging 2
-!Imaging 3
-!Histopathology
 |'''Gold standard'''
-!Additional findings
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 | rowspan="3" style="background: #DCDCDC; padding: 5px; text-align: center;" |Tissue iron overload
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 |}

Sideroblastic anemia differential diagnosis: Difference between revisions

Revision as of 17:55, 2 August 2018

Overview

Differential Diagnosis

References

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