Sideroblastic anemia differential diagnosis: Difference between revisions

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Revision as of 16:18, 2 August 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.

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Overview

Differential Diagnosis

Sideroblastic anemia must be differentiated from other causes of microcytic hypochromic anemia: iron deficiency anemia, thalassemia, anemia of chronic disease, lead poisoning, and blood loss.

• Tissue iron overload from sideroblastic anemia may act similar to hereditary hemochromatosis with liver cirrhosis, diabetes, congestive heart failure, and cardiac arrhythmias.

ALA Dehydratase Deficiency Porphyria
Acute Myeloid Leukemia (AML)
Congenital Erythropoietic Porphyria
Hereditary Coproporphyria
Iron Deficiency Anemia
Myelodysplastic Syndrome
Secondary Thrombocytosis

On the basis [symptom 1], [symptom 2], and [symptom 3], [disease name] must be differentiated from [disease 1], [disease 2], [disease 3], [disease 4], [disease 5], and [disease 6].

		Symptoms			Physical examination			Lab Findings						Imaging			Histopathology
Diseases		Clinical manifestations						Para-clinical findings										Gold standard	Additional findings
		Symptoms			Physical examination			Para-clinical findings
		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Peripheral blood smear	Serum iron	Serum TIBC	Serum ferritin g/L	Iron in erythroblasts	Iron stores in bone marrow	Imaging 1	Imaging 2	Imaging 3	Histopathology
	Sideroblastic anemia							variable	Normal -high	Normal	50-300	present in ring form	present
Microcytic hypochromic anemia	Iron deficiency anemia	pallor						microcytic/ hypochromic	<30	> 360	<15	absent	absent
	Thalasemia							micro/hypo with targeting	Normal -high	Normal	50-300	present	present
	Anemia of chronic disease							Normal	Low	<300	30-200	absent	present
	Lead poisoning
	Blood loss
Diseases		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3				Imaging 1	Imaging 2	Imaging 3	Histopathology	Gold standard	Additional findings
Tissue iron overload

References

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@@ Line 25: / Line 25: @@
 ! colspan="2" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
 | colspan="6" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Clinical manifestations'''
-! colspan="7" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
+! colspan="12" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Para-clinical findings
 | colspan="1" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |'''Gold standard'''
 ! rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Additional findings
@@ Line 32: / Line 32: @@
 ! colspan="3" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical examination
 |-
-! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
+! colspan="8" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab Findings
 ! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging
 ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
@@ Line 42: / Line 42: @@
 ! colspan="1" rowspan="1" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical exam 2
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Physical exam 3
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab 1
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Peripheral blood smear
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab 2
+! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum iron
-! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Lab 3
+! colspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Serum TIBC
+!Serum ferritin
+g/L
+!Iron in erythroblasts
+!Iron stores in bone marrow
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 1
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 2
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging 3
+|-
+|
+|Sideroblastic anemia
+|
+|
+|
+|
+|
+|
+|variable
+|Normal -high
+| colspan="3" |Normal
+|50-300
+|present in ring form
+|present
+|
+|
+|
+|
+|
+|
 |-
 | rowspan="5" style="background: #DCDCDC; padding: 5px; text-align: center;" |Microcytic hypochromic
 anemia
 |Iron deficiency anemia
+| style="background: #F5F5F5; padding: 5px;" |pallor
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
@@ Line 57: / Line 83: @@
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |microcytic/
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+hypochromic
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |<30
+| colspan="3" style="background: #F5F5F5; padding: 5px;" |> 360
+|<15
+|absent
+|absent
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
@@ Line 75: / Line 105: @@
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |micro/hypo with targeting
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |Normal -high
-| style="background: #F5F5F5; padding: 5px;" |
+| colspan="3" style="background: #F5F5F5; padding: 5px;" |Normal
+|50-300
+|present
+|present
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
@@ Line 92: / Line 125: @@
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |Normal
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |Low
-| style="background: #F5F5F5; padding: 5px;" |
+| colspan="3" style="background: #F5F5F5; padding: 5px;" |<300
+|30-200
+|absent
+|present
 | style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
@@ Line 109: / Line 145: @@
 |
 |
+|
+|
+| colspan="3" |
 |
 |
@@ Line 126: / Line 165: @@
 |
 |
+|
+|
+| colspan="3" |
 |
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@@ Line 146: / Line 188: @@
 !Lab 2
 !Lab 3
+!
+!
+!
+!
+!
 !Imaging 1
 !Imaging 2
@@ Line 164: / Line 211: @@
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+|
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Sideroblastic anemia differential diagnosis: Difference between revisions

Revision as of 16:18, 2 August 2018

Overview

Differential Diagnosis

References

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