Sickle-cell disease differential diagnosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]
Overview
In some cases, it can be difficult to differentiate sickle cell disease from other diagnoses, given that there may be significant overlap of symptoms.[1]
Differential Diagnosis
- The differential diagnosis of sickle cell disease includes other conditions that may present with fatigue, infection, bone pain, such as:
- Thalassemia
- Acute leukemia
- Autoimmune hemolytic anemia[1]
- HbSC disease
- HbS-beta-thalassemia
- Septic arthritis[2]
- Polycythemia vera
- Systemic lupus erythematosus
- Other hemoglobinopathies
References
- ↑ 1.0 1.1 Sankaran VG, Weiss MJ (2015). "Anemia: progress in molecular mechanisms and therapies". Nat Med. 21 (3): 221–30. doi:10.1038/nm.3814. PMC 4452951. PMID 25742458.
- ↑ Hernigou P, Daltro G, Flouzat-Lachaniette CH, Roussignol X, Poignard A (2010). "Septic arthritis in adults with sickle cell disease often is associated with osteomyelitis or osteonecrosis". Clin Orthop Relat Res. 468 (6): 1676–81. doi:10.1007/s11999-009-1149-3. PMC 2865595. PMID 19885711.