Sickle-cell disease differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shyam Patel [2]

Overview

In some cases, it can be difficult to differentiate sickle cell disease from other diagnoses, given that there may be significant overlap of symptoms.

Differential Diagnosis

• The differential diagnosis of sickle cell disease includes other conditions that may present with fatigue, infection, bone pain, such as:

• Thalassemia
• Acute leukemia
• Autoimmune hemolytic anemia
• HbSC disease
• HbS-beta-thalassemia
• Septic arthritis
• Polycythemia vera
• Systemic lupus erythematosus
• Other hemoglobinopathies