Seminoma surgery
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Seminoma surgery On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Radical inguinal orchiectomy is the first treatment for any stage of testicular seminoma and it is usually done as part of diagnosis.
Surgery
- Surgery is usually reserved for majority of patients.The feasibility of surgery depends on the stage of seminomsat diagnosis.[1][2][3]
- The feasibility of surgery depends on the stage of seminoma at diagnosis.
- Surgery is the mainstay of treatment for seminoma.
- Diagnose and help stage the cancer
- Completely remove the tumor
- Remove tumors that have spread to other parts of the body, such as the lungs
- Remove any residual disease
- The following are the types of surgery most commonly used to treat testicular semiono, which include:[4][5][6][7]
- Radical inguinal orchiectomy
- Retroperitoneal lymph node dissection
- Salvage surgery
- Surgery for metastases
Radical Inguinal Orchiectomy
- Among patients who present with clinically advanced disease, radical orchiectomy is useful to remove the tumor prior to chemotherapy when possible.
Retroperitoneal Lymph Node Dissection
- Retroperitoneal lymph node dissection (RPLND) may be helpful for any type of seminoma that doesn’t respond to chemotherapy.[7]
- RPLND may be helpful at the same time as orchiectomy, or it can be done later during other surgery.[8]
Salvage Surgery
- Sometimes, seminoma doesn’t completely respond to chemotherapy given after an orchiectomy. The cancer that remains after these primary treatments is called residual disease. Surgery used to remove residual disease is called salvage surgery. If there are high levels of tumor markers in the blood, salvage surgery may be performed to remove residual disease.[9]
- Salvage surgery may include a bilateral RPLND, if it wasn’t done during a previous surgery.
Surgery for Metastases
- Surgery may also be used to remove seminoma that has metastasized to the lung, mediastinum, brain, liver, or neck.
Surgery
- The feasibility of surgery depends on the stage of [malignancy] at diagnosis.
OR
- Surgery is the mainstay of treatment for [disease or malignancy].
References
- ↑ Batool A, Karimi N, Wu XN, Chen SR, Liu YX (May 2019). "Testicular germ cell tumor: a comprehensive review". Cell. Mol. Life Sci. 76 (9): 1713–1727. doi:10.1007/s00018-019-03022-7. PMID 30671589.
- ↑ Boujelbene, Noureddine; Cosinschi, Adrien; Boujelbene, Nadia; Khanfir, Kaouthar; Bhagwati, Shushila; Herrmann, Eveleyn; Mirimanoff, Rene-Olivier; Ozsahin, Mahmut; Zouhair, Abderrahim (2011). "Pure seminoma: A review and update". Radiation Oncology. 6 (1). doi:10.1186/1748-717X-6-90. ISSN 1748-717X.
- ↑ Al-Salem, Ahmed H. (2014). "Testicular Tumors": 505–511. doi:10.1007/978-3-319-06665-3_64.
- ↑ Boujelbene N, Cosinschi A, Boujelbene N, Khanfir K, Bhagwati S, Herrmann E, Mirimanoff RO, Ozsahin M, Zouhair A (August 2011). "Pure seminoma: a review and update". Radiat Oncol. 6: 90. doi:10.1186/1748-717X-6-90. PMC 3163197. PMID 21819630.
- ↑ Oldenburg J, Fosså SD, Nuver J, Heidenreich A, Schmoll HJ, Bokemeyer C, Horwich A, Beyer J, Kataja V (October 2013). "Testicular seminoma and non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up". Ann. Oncol. 24 Suppl 6: vi125–32. doi:10.1093/annonc/mdt304. PMID 24078656.
- ↑ Carver BS, Serio AM, Bajorin D, Motzer RJ, Stasi J, Bosl GJ, Vickers AJ, Sheinfeld J (December 2007). "Improved clinical outcome in recent years for men with metastatic nonseminomatous germ cell tumors". J. Clin. Oncol. 25 (35): 5603–8. doi:10.1200/JCO.2007.13.6283. PMID 17998544.
- ↑ 7.0 7.1 Lavery HJ, Bahnson RR, Sharp DS, Pohar KS (October 2009). "Management of the residual post-chemotherapy retroperitoneal mass in germ cell tumors". Ther Adv Urol. 1 (4): 199–207. doi:10.1177/1756287209350315. PMC 3126061. PMID 21789067.
- ↑
- ↑ Surgery for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/surgery/?region=on. Accessed on March 2, 2016