Sarcomatoid carcinoma of the lung natural history, complications and prognosis: Difference between revisions
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The majority of patients with non-small cell lung cancer are initially asymptomatic.<ref name="pmid17356101">{{cite journal |vauthors=Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E |title=Prognosis of lung cancer patients with life-threatening complications |journal=Chest |volume=131 |issue=3 |pages=840–6 |year=2007 |pmid=17356101 |doi=10.1378/chest.06-2244 |url=}}</ref> | The majority of patients with non-small cell lung cancer are initially asymptomatic.<ref name="pmid17356101">{{cite journal |vauthors=Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E |title=Prognosis of lung cancer patients with life-threatening complications |journal=Chest |volume=131 |issue=3 |pages=840–6 |year=2007 |pmid=17356101 |doi=10.1378/chest.06-2244 |url=}}</ref> | ||
*The symptoms of non-small cell lung cancer usually develop in adult patients between 65 to 74 years. | *The symptoms of non-small cell lung cancer usually develop in adult patients between 65 to 74 years. | ||
*Initially, patients complain of [[Cough|chronic cough]], [[ | **The majority of patients with sarcomatoid carcinoma of the lung remain are initially asymptomatic. | ||
**Early clinical features include chronic [[cough]], [[hemoptysis]], [[dyspnea]], [[weight loss]] and [[fatigue]].<ref>{{cite book |last1=Travis WD |last2=Brambilla E |last3=Müller-Hermelink K |last4=Harris C |last5=Kleihues C |last6=Sobin P |title=World Health Organization Classification of Tumours; Pathology and genetics of tumors of the lung, pleura, thymus, and heart |publisher=IARC Press |orig-year=2004 |pages=53-58|chapterurl=https://www.iarc.fr/wp-content/uploads/2018/07/BB10.pdf |isbn=ISBN 92 832 2418 3}}</ref> | |||
**The majority of patients with central sarcomatoid carcinoma of the lung may develop distant metastasis to esophagus, jejunum, rectum and kidney. | |||
**Sarcomatoid carcinoma of lung located in the periphery of lungs tends be diagnosed later in the advanced stages with the large size and metastasis to the pleura and chest wall. | |||
*Initially, patients complain of [[Cough|chronic cough]], [[Dyspnea|dyspnea,]] and [[weight-loss]]. | |||
*If left untreated, patients with non-small cell lung cancer may develop local invasion to lymph nodes and distant metastasis. | *If left untreated, patients with non-small cell lung cancer may develop local invasion to lymph nodes and distant metastasis. | ||
*Common sites of metastasis include the [[adrenal gland]], [[Bone tumors|bone]], [[brain]], and [[liver]]. | *Common sites of metastasis include the [[adrenal gland]], [[Bone tumors|bone]], [[brain]], and [[liver]]. | ||
==Complications== | ==Complications== | ||
Common complications of | Common complications of sarcomatoid carcinoma of the lung, include:<ref name="pmid17356101">{{cite journal |vauthors=Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E |title=Prognosis of lung cancer patients with life-threatening complications |journal=Chest |volume=131 |issue=3 |pages=840–6 |year=2007 |pmid=17356101 |doi=10.1378/chest.06-2244 |url=}}</ref> | ||
*[[Respiratory failure|Acute respiratory failure]] | *[[Respiratory failure|Acute respiratory failure]] | ||
*[[Respiratory acidosis]] | *[[Respiratory acidosis]] | ||
| Line 27: | Line 31: | ||
* The 3-year and 5-year survival rates for patients with sarcomatoid cancer of lung are 35.8 and 28.7%.<ref name="RoeselTerjung2016">{{cite journal|last1=Roesel|first1=Christian|last2=Terjung|first2=Sarah|last3=Weinreich|first3=Gerhard|last4=Hager|first4=Thomas|last5=Chalvatzoulis|first5=Eleftherios|last6=Metzenmacher|first6=Martin|last7=Welter|first7=Stefan|title=Sarcomatoid carcinoma of the lung: a rare histological subtype of non-small cell lung cancer with a poor prognosis even at earlier tumour stages|journal=Interactive CardioVascular and Thoracic Surgery|year=2016|pages=ivw392|issn=1569-9293|doi=10.1093/icvts/ivw392}}</ref> | * The 3-year and 5-year survival rates for patients with sarcomatoid cancer of lung are 35.8 and 28.7%.<ref name="RoeselTerjung2016">{{cite journal|last1=Roesel|first1=Christian|last2=Terjung|first2=Sarah|last3=Weinreich|first3=Gerhard|last4=Hager|first4=Thomas|last5=Chalvatzoulis|first5=Eleftherios|last6=Metzenmacher|first6=Martin|last7=Welter|first7=Stefan|title=Sarcomatoid carcinoma of the lung: a rare histological subtype of non-small cell lung cancer with a poor prognosis even at earlier tumour stages|journal=Interactive CardioVascular and Thoracic Surgery|year=2016|pages=ivw392|issn=1569-9293|doi=10.1093/icvts/ivw392}}</ref> | ||
* Non-small cell lung cancer [[survival rate]] ranges from 1% to 52% (stage I to stage IV). | * Non-small cell lung cancer [[survival rate]] ranges from 1% to 52% (stage I to stage IV). | ||
==References== | ==References== | ||
Revision as of 17:00, 2 January 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Trusha Tank, M.D.[2]
Overview
Sarcomatoid carcinoma of the lung progresses slowly and is followed by local invasion to lymph nodes, chest wall, pleura and distant metastasis. Sarcomatoid carcinoma of the lung is a type of non-small cell lung cancer. Non-small cell lung cancer is locally aggressive malignancy, which commonly occurs in adult patients between 65 to 74 years. Common sites of metastasis include the adrenal gland, bone, brain, and liver. Complications of non-small cell lung cancer include acute respiratory failure, respiratory acidosis, malignant pleural effusion, metastases, and pneumonia. The 3-year and 5-year survival rates for patients with sarcomatoid cancer of lung are 35.8% and 28.7%. Features associated with worse prognosis are presence of lymphatic invasion, location of lesion, and presence of regional or distant metastases. Prognosis is generally regarded as poor.
Natural History
The majority of patients with non-small cell lung cancer are initially asymptomatic.[1]
- The symptoms of non-small cell lung cancer usually develop in adult patients between 65 to 74 years.
- The majority of patients with sarcomatoid carcinoma of the lung remain are initially asymptomatic.
- Early clinical features include chronic cough, hemoptysis, dyspnea, weight loss and fatigue.[2]
- The majority of patients with central sarcomatoid carcinoma of the lung may develop distant metastasis to esophagus, jejunum, rectum and kidney.
- Sarcomatoid carcinoma of lung located in the periphery of lungs tends be diagnosed later in the advanced stages with the large size and metastasis to the pleura and chest wall.
- Initially, patients complain of chronic cough, dyspnea, and weight-loss.
- If left untreated, patients with non-small cell lung cancer may develop local invasion to lymph nodes and distant metastasis.
- Common sites of metastasis include the adrenal gland, bone, brain, and liver.
Complications
Common complications of sarcomatoid carcinoma of the lung, include:[1]
- Acute respiratory failure
- Respiratory acidosis
- Malignant pleural effusion
- Metastases
- Recurrent pneumonia
Prognosis
Prognosis of sarcomatoid carcinoma of the lung depends on the origin of the tumor, histological type, and stage.[1]
- Prognosis of sarcomatoid carcinoma of the lung is generally poor.
- The 3-year and 5-year survival rates for patients with sarcomatoid cancer of lung are 35.8 and 28.7%.[3]
- Non-small cell lung cancer survival rate ranges from 1% to 52% (stage I to stage IV).
References
- ↑ 1.0 1.1 1.2 Soares M, Darmon M, Salluh JI, Ferreira CG, Thiéry G, Schlemmer B, Spector N, Azoulay E (2007). "Prognosis of lung cancer patients with life-threatening complications". Chest. 131 (3): 840–6. doi:10.1378/chest.06-2244. PMID 17356101.
- ↑ Travis WD; Brambilla E; Müller-Hermelink K; Harris C; Kleihues C; Sobin P. https://www.iarc.fr/wp-content/uploads/2018/07/BB10.pdf
|chapterurl=missing title (help) (PDF). World Health Organization Classification of Tumours; Pathology and genetics of tumors of the lung, pleura, thymus, and heart. IARC Press. pp. 53–58. ISBN ISBN 92 832 2418 3 Check|isbn=value: invalid character (help). - ↑ Roesel, Christian; Terjung, Sarah; Weinreich, Gerhard; Hager, Thomas; Chalvatzoulis, Eleftherios; Metzenmacher, Martin; Welter, Stefan (2016). "Sarcomatoid carcinoma of the lung: a rare histological subtype of non-small cell lung cancer with a poor prognosis even at earlier tumour stages". Interactive CardioVascular and Thoracic Surgery: ivw392. doi:10.1093/icvts/ivw392. ISSN 1569-9293.