Sandbox: wdx causes: Difference between revisions
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{| | {| | ||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | ||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" | | ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Condition | ||
! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ! rowspan="5" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ||
! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism | ! colspan="3" rowspan="4" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mechanism | ||
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! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging | ! rowspan="3" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Imaging | ||
|- | |- | ||
! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" | | ! colspan="1" rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" | | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding | ||
! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | ! rowspan="2" style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | ||
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/ | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Destruction/ | ||
sequestration/ | sequestration/ | ||
redistribution | redistribution | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Plt | ||
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|- | |- | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Category | ||
! | !Condition | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Etiology | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Decreased platelet production | ||
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! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Demography | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |History | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Appearance | |||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Fever | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding | ||
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP | ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |BP |
Revision as of 20:14, 4 September 2018
Differentiating Pancytopenia from Other Diseases
- Pancytopenia must be differentiated from a pseudo-syndromes like pseudo-thrombocytopenia, which is a laboratory artifact from platelet clumping.
- There are no other mimickers of pancytopenia, as the diagnosis can be unequivocally established by laboratory testing (complete blood count).
Category | Condition | Etiology | Mechanism | Congenital | Acquried | Clinical manifestations | Para−clinical findings | Gold standard | Associated findings | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Demography | History | Symptoms | Signs | ||||||||||||||||||||||||
Lab Findings | Imaging | ||||||||||||||||||||||||||
Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other | CBC | PBS | Bone marrow exam | PT | PTT | UA | |||||||||||||||
Bone marrow infiltration | Bone marrow failure | Destruction/
sequestration/ redistribution |
Plt | HB | WBC | ||||||||||||||||||||||
Hematologic disorders | Myelodysplastic syndromes (MDS) |
|
|||||||||||||||||||||||||
Malignancies such as:
|
|
+ | + | + | |||||||||||||||||||||||
Myelofibrosis | Bone marrow infiltration | + | |||||||||||||||||||||||||
Fanconi anemia | + | ||||||||||||||||||||||||||
Aplastic anemia | Immune destruction | + | |||||||||||||||||||||||||
Paroxysmal nocturnal hemoglobinuria | Immune destruction | + | |||||||||||||||||||||||||
Disseminated intravascular coagulation | Consumption | + | |||||||||||||||||||||||||
Dyskeratosis congenital/telomere biology disorders | + | ||||||||||||||||||||||||||
Shwachman-Diamond syndrome | + | ||||||||||||||||||||||||||
Immunology/
Rheumatology |
SLE | ||||||||||||||||||||||||||
Felty syndrome | |||||||||||||||||||||||||||
Wiskott Aldrich syndrome | + | ||||||||||||||||||||||||||
GATA2 deficiency | + | ||||||||||||||||||||||||||
Hemophagocytic lymphohistiocytosis (HLH) | + | ||||||||||||||||||||||||||
GI disorders | Portal hypertension/cirrhosis | Splenomegaly | + | ||||||||||||||||||||||||
Storage diseases (eg, Gaucher) |
|
+ | + | ||||||||||||||||||||||||
Infections | Sepsis | Bone marrow infiltration | + | ||||||||||||||||||||||||
Viral infection such as HIV, hepatitis, Epstein-Barr virus |
|
+ | + | ||||||||||||||||||||||||
Nutritional | Megaloblastic anemia | Ineffective hematopoiesis | + | ||||||||||||||||||||||||
Excessive alcohol | Ineffective hematopoiesis | ||||||||||||||||||||||||||
Other (eg, copper deficiency, zinc toxicity) | Ineffective hematopoiesis | ||||||||||||||||||||||||||
Malnutrition | Ineffective hematopoiesis | ||||||||||||||||||||||||||
Medications | Medications such as:
|
Immune destruction | + | ||||||||||||||||||||||||
Category | Condition | Etiology | Decreased platelet production | Platelet destruction in blood | Platelet destruction in spleen | Congenital | Acquried | Demography | History | Appearance | Fever | Bleeding | BP | Splenomegaly | Jaundice | Other signs | Plt | HB | WBC | PBS | Bone marrow exam | PT | PTT | UA | Imaging | Gold standard | Associated findings |