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==Overview==
==Overview==
Mild to moderate vitamin D deficiency could be asymptomatic in children and adults. However, severe vitamin D deficiency may be presented as rickets in children and osteomalacia in adults. Some nonspecific associated symptoms including muscle weakness or bone pain may be seen. <ref name="pmid19835345">{{cite journal |vauthors=Bordelon P, Ghetu MV, Langan RC |title=Recognition and management of vitamin D deficiency |journal=Am Fam Physician |volume=80 |issue=8 |pages=841–6 |year=2009 |pmid=19835345 |doi= |url=http://www.aafp.org/link_out?pmid=19835345}}</ref>
Mild to moderate vitamin D deficiency could be asymptomatic in children and adults. However, severe vitamin D deficiency may be presented as rickets in children and osteomalacia in adults. Some nonspecific associated symptoms including muscle weakness or bone pain may be seen. <ref name="pmid19835345">{{cite journal |vauthors=Bordelon P, Ghetu MV, Langan RC |title=Recognition and management of vitamin D deficiency |journal=Am Fam Physician |volume=80 |issue=8 |pages=841–6 |year=2009 |pmid=19835345 |doi= |url=http://www.aafp.org/link_out?pmid=19835345}}</ref> <ref name="LeFevre2015">{{cite journal|last1=LeFevre|first1=Michael L.|title=Screening for Vitamin D Deficiency in Adults: U.S. Preventive Services Task Force Recommendation Statement|journal=Annals of Internal Medicine|volume=162|issue=2|year=2015|pages=133|issn=0003-4819|doi=10.7326/M14-2450}}</ref>
 


==History==
==History==


==Symptoms==
==Symptoms==
* Growth retardation <ref name="pmid18400738">{{cite journal |vauthors=Holick MF, Chen TC |title=Vitamin D deficiency: a worldwide problem with health consequences |journal=Am. J. Clin. Nutr. |volume=87 |issue=4 |pages=1080S–6S |year=2008 |pmid=18400738 |doi= |url=http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=18400738}}</ref>
* Osteopenia <ref name="pmid18400738">{{cite journal |vauthors=Holick MF, Chen TC |title=Vitamin D deficiency: a worldwide problem with health consequences |journal=Am. J. Clin. Nutr. |volume=87 |issue=4 |pages=1080S–6S |year=2008 |pmid=18400738 |doi= |url=http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=18400738}}</ref>
* Osteomalacia  
* Osteomalacia  
* Rickets <ref name="Holick2006">{{cite journal|last1=Holick|first1=M. F.|title=Resurrection of vitamin D deficiency and rickets|journal=Journal of Clinical Investigation|volume=116|issue=8|year=2006|pages=2062–2072|issn=0021-9738|doi=10.1172/JCI29449}}</ref>
* Rickets <ref name="Holick2006">{{cite journal|last1=Holick|first1=M. F.|title=Resurrection of vitamin D deficiency and rickets|journal=Journal of Clinical Investigation|volume=116|issue=8|year=2006|pages=2062–2072|issn=0021-9738|doi=10.1172/JCI29449}}</ref>
Line 18: Line 21:
* Throbbing bone pain  
* Throbbing bone pain  
* Fall <ref name="HolickBinkley2011">{{cite journal|last1=Holick|first1=Michael F.|last2=Binkley|first2=Neil C.|last3=Bischoff-Ferrari|first3=Heike A.|last4=Gordon|first4=Catherine M.|last5=Hanley|first5=David A.|last6=Heaney|first6=Robert P.|last7=Murad|first7=M. Hassan|last8=Weaver|first8=Connie M.|title=Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline|journal=The Journal of Clinical Endocrinology & Metabolism|volume=96|issue=7|year=2011|pages=1911–1930|issn=0021-972X|doi=10.1210/jc.2011-0385}}</ref>
* Fall <ref name="HolickBinkley2011">{{cite journal|last1=Holick|first1=Michael F.|last2=Binkley|first2=Neil C.|last3=Bischoff-Ferrari|first3=Heike A.|last4=Gordon|first4=Catherine M.|last5=Hanley|first5=David A.|last6=Heaney|first6=Robert P.|last7=Murad|first7=M. Hassan|last8=Weaver|first8=Connie M.|title=Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline|journal=The Journal of Clinical Endocrinology & Metabolism|volume=96|issue=7|year=2011|pages=1911–1930|issn=0021-972X|doi=10.1210/jc.2011-0385}}</ref>
* Fracture
* Fracture <ref name="pmid18400738">{{cite journal |vauthors=Holick MF, Chen TC |title=Vitamin D deficiency: a worldwide problem with health consequences |journal=Am. J. Clin. Nutr. |volume=87 |issue=4 |pages=1080S–6S |year=2008 |pmid=18400738 |doi= |url=http://www.ajcn.org/cgi/pmidlookup?view=long&pmid=18400738}}</ref>
* Difficulty walking
* Difficulty walking



Revision as of 21:06, 1 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Sadaf Sharfaei M.D.[2]

Overview

Mild to moderate vitamin D deficiency could be asymptomatic in children and adults. However, severe vitamin D deficiency may be presented as rickets in children and osteomalacia in adults. Some nonspecific associated symptoms including muscle weakness or bone pain may be seen. [1] [2]


History

Symptoms

  • Growth retardation [3]
  • Osteopenia [3]
  • Osteomalacia
  • Rickets [4]

Associated symptoms

  • Nonspecific musculoskeletal pain [5]
  • Muscle weakness [6]
  • Symmetric low back pain [1]
  • Throbbing bone pain
  • Fall [7]
  • Fracture [3]
  • Difficulty walking

References

  1. 1.0 1.1 Bordelon P, Ghetu MV, Langan RC (2009). "Recognition and management of vitamin D deficiency". Am Fam Physician. 80 (8): 841–6. PMID 19835345.
  2. LeFevre, Michael L. (2015). "Screening for Vitamin D Deficiency in Adults: U.S. Preventive Services Task Force Recommendation Statement". Annals of Internal Medicine. 162 (2): 133. doi:10.7326/M14-2450. ISSN 0003-4819.
  3. 3.0 3.1 3.2 Holick MF, Chen TC (2008). "Vitamin D deficiency: a worldwide problem with health consequences". Am. J. Clin. Nutr. 87 (4): 1080S–6S. PMID 18400738.
  4. Holick, M. F. (2006). "Resurrection of vitamin D deficiency and rickets". Journal of Clinical Investigation. 116 (8): 2062–2072. doi:10.1172/JCI29449. ISSN 0021-9738.
  5. Plotnikoff GA, Quigley JM (2003). "Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain". Mayo Clin. Proc. 78 (12): 1463–70. doi:10.4065/78.12.1463. PMID 14661675.
  6. Holick MF (2003). "Vitamin D deficiency: what a pain it is". Mayo Clin. Proc. 78 (12): 1457–9. doi:10.4065/78.12.1457. PMID 14661673.
  7. Holick, Michael F.; Binkley, Neil C.; Bischoff-Ferrari, Heike A.; Gordon, Catherine M.; Hanley, David A.; Heaney, Robert P.; Murad, M. Hassan; Weaver, Connie M. (2011). "Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline". The Journal of Clinical Endocrinology & Metabolism. 96 (7): 1911–1930. doi:10.1210/jc.2011-0385. ISSN 0021-972X.


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