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==Overview==
==Overview==
Salivary gland tumor may be classified according to World Health Organization into five groups: Malignant epithelial tumors, benign epithelial tumors, soft tissue tumors, hematolymphoid tumors, and secondary tumors.<ref name="wiki">  Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015</ref>
Salivary gland tumor may be classified according to the World Health Organization into five groups: [[malignant]] [[epithelial]] [[tumors]], [[benign]] [[epithelial]] [[tumors]], [[soft tissue tumors]], hematolymphoid tumors, and secondary tumors.<ref name="wiki">  Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015</ref>
==Classification==
==Classification==
The parotid gland is the most frequent site of salivary gland tumors which accounts for approximately 80 to 85 percent of these tumors.<ref>Barnes, Leon. Pathology and genetics of head and neck tumours. Lyon: IARC Press, 2005. Print.</ref> <ref>{{Cite journal
Due to diverse nature of salivary gland neoplasms, many different terms and classification systems have been used. The World Health Organization in 2004, classified salivary neoplasms as primary or secondary, [[benign]] or [[malignant]], and also by tissue of origin. This system defines five broad categories of salivary gland neoplasms:<ref name="wiki">  Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015</ref>
| author = [[Marco Guzzo]], [[Laura D. Locati]], [[Franz J. Prott]], [[Gemma Gatta]], [[Mark McGurk]] & [[Lisa Licitra]] | title = Major and minor salivary gland tumors
| journal = [[Critical reviews in oncology/hematology]] | volume = 74 | issue = 2 | pages = 134–148 | year = 2010 | month = May | doi = 10.1016/j.critrevonc.2009.10.004
| pmid = 019939701}}</ref> About 75 percent of parotid lesions are benign and approximately 25 percent are malignant.<ref>{{Cite journal | author = [[R. H. Spiro]]
| title = Salivary neoplasms: overview of a 35-year experience with 2,807 patients | journal = [[Head & neck surgery]] | volume = 8 | issue = 3 | pages = 177–184 | year = 1986 | month = January-February | pmid = 03744850}}</ref>
Less frequently, salivary gland tumors originate in the sublingual, submandibular, and minor salivary glands, which are located throughout the submucosa of the upper aerodigestive tract and  mouth.<ref>{{Cite journal | author = [[Marco Guzzo]], [[Laura D. Locati]], [[Franz J. Prott]], [[Gemma Gatta]], [[Mark McGurk]] & [[Lisa Licitra]]
| title = Major and minor salivary gland tumors | journal = [[Critical reviews in oncology/hematology]] | volume = 74 | issue = 2 | pages = 134–148 | year = 2010
| month = May | doi = 10.1016/j.critrevonc.2009.10.004 | pmid = 019939701}}</ref>.
In comparison to tumors arising in the parotid,
*40 to 45 percent of submandibular gland tumors
*70 to 90 percent of sublingual gland tumors
*50 to 75 percent of minor salivary gland tumors are malignant.
Histologically, pleomorphic adenoma is the most common type of benign salivary gland tumor, which comprises about half of all salivary tumors. Other rarer benign salivary gland tumors include  basal cell adenoma, Warthin tumor, and canalicular adenoma. The most common malignant salivary gland tumors are adenoid cystic carcinoma and mucoepidermoid carcinoma, which together constitutes approximately one-half of all malignant salivary gland tumors.
Due to diverse nature of salivary gland neoplasms, many different terms and classification systems have been used. Perhaps the most widely used currently is that system proposed by the World Health Organization in 2004, which classifies salivary neoplasms as primary or secondary, benign or malignant, and also by tissue of origin. This system defines five broad categories of salivary gland neoplasms:<ref name="wiki">  Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015</ref>
===Malignant epithelial tumors===
===Malignant epithelial tumors===
*Acinic cell carcinoma
*[[Acinic cell carcinoma]]
*Mucoepidermoid carcinoma
*[[Mucoepidermoid carcinoma]]
*Adenoid cystic carcinoma
*[[Adenoid]] [[cystic]] carcinoma
*Polymorphous low-grade adenocarcinoma
*Polymorphous low-grade [[adenocarcinoma]]
*Epithelial-myoepithelial carcinoma
*[[Epithelial]]-[[myoepithelial]] carcinoma
*Clear cell carcinoma, not otherwise specified
*[[Clear cell]] carcinoma, not otherwise specified
*Basal cell adenocarcinoma
*[[Basal cell]] [[adenocarcinoma]]
*Sebaceous carcinoma
*[[Sebaceous]] [[carcinoma]]
*Sebaceous lymphadenocarcinoma
*[[Sebaceous]] lymphadenocarcinoma
*Cystadenocarcinoma
 
*Low-grade cribriform cystadenocarcinoma
*[[Cystadenocarcinoma]]
*Mucinous adenocarcinoma
*Low-grade [[cribriform]] [[cystadenocarcinoma]]
*Oncocytic carcinoma
*[[Mucinous]] [[adenocarcinoma]]
*Salivary duct carcinoma
*Oncocytic [[carcinoma]]
*Salivary duct carcinoma, not otherwise specified
*Salivary [[duct]] carcinoma
*Adenocarcinoma, not otherwise specified
*Salivary duct [[carcinoma]], not otherwise specified
*Myoepithelial carcinoma
*[[Adenocarcinoma]], not otherwise specified
*Carcinoma ex pleomorphic adenoma
*[[Myoepithelial]] [[carcinoma]]
*Carcinosarcoma
*Carcinoma ex [[pleomorphic adenoma]]
*Metastasizing pleomorphic adenoma
*[[Carcinosarcoma]]
*Squamous cell carcinoma
*Metastasizing [[pleomorphic adenoma]]
*Large cell carcinoma
*[[Squamous cell carcinoma]]
*Lymphoepithelial carcinoma
*[[Large cell]] [[carcinoma]]
*[[Lymphoepithelial carcinoma]]
*Sialoblastoma
*Sialoblastoma
===Benign epithelial tumors===
===Benign epithelial tumors===
*Pleomorphic adenoma
*[[Pleomorphic adenoma]]
*Myoepithelioma
*[[Myoepithelioma]]
*Basal cell adenoma
*Basal cell adenoma
*Warthin's tumor
*[[Warthin's tumor]]
*Oncocytoma
*[[Oncocytoma]]
*Canalicular adenoma
*Canalicular adenoma
*Lymphadenoma
*[[Lymphadenoma]]
*Sebaceous lymphadenoma
*[[Sebaceous]] [[lymphadenoma]]
*Nonsebaceous lymphadenoma
*[[Nonsebaceous]] [[lymphadenoma]]
*Ductal papilloma
*Ductal [[papilloma]]
*Inverted ductal papilloma
*Inverted [[ductal papilloma]]
*Intraductal papilloma
*[[Intraductal papilloma]]
*Sialadenoma papilliferum
*[[Sialadenoma]] papilliferum
*Cystadenoma
*[[Cystadenoma]]
===Soft tissue tumors===
===Soft tissue tumors===
*Hemangioma
*[[Hemangioma]]
===Hematolymphoid tumors===
===Hematolymphoid tumors===
*Hodgkin lymphoma
*[[Hodgkin]] [[lymphoma]]
*Diffuse large B-cell lymphoma
*Diffuse large [[B-cell lymphoma]]
*Extranodal marginal zone B cell lymphoma
*Extranodal marginal zone B cell lymphoma
===Secondary tumors===
===Secondary tumors===
Secondary tumor is a tumor which has metastasized to the salivary gland from a distant location.
Secondary tumor is a tumor which has metastasized to the salivary gland from a distant location.
===Tumors not included in the WHO classification above, include:===
===Tumors not included in the WHO classification above, include:===
*Intraosseous (central) salivary gland tumors
*[[Intraosseous]] (central) salivary gland tumors
*Hybrid tumors
*Hybrid tumors
:Hybrid tumor is a tumor displaying combined forms of histologic tumor types.
:Hybrid [[tumor]] is a tumor displaying combined forms of histologic tumor types.
:*Hybrid carcinoma
:*Hybrid carcinoma
:*Others
:*Others
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==References==
==References==
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{{reflist|2}}
 
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Latest revision as of 15:27, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]}Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Salivary gland tumor may be classified according to the World Health Organization into five groups: malignant epithelial tumors, benign epithelial tumors, soft tissue tumors, hematolymphoid tumors, and secondary tumors.[1]

Classification

Due to diverse nature of salivary gland neoplasms, many different terms and classification systems have been used. The World Health Organization in 2004, classified salivary neoplasms as primary or secondary, benign or malignant, and also by tissue of origin. This system defines five broad categories of salivary gland neoplasms:[1]

Malignant epithelial tumors

Benign epithelial tumors

Soft tissue tumors

Hematolymphoid tumors

Secondary tumors

Secondary tumor is a tumor which has metastasized to the salivary gland from a distant location.

Tumors not included in the WHO classification above, include:

Hybrid tumor is a tumor displaying combined forms of histologic tumor types.
  • Hybrid carcinoma
  • Others
  • Others
    • Keratocystoma
    • Sialolipoma

References

  1. ↑ 1.0 1.1 Salivary gland neoplasm. Wikipedia(2015) https://en.wikipedia.org/wiki/Salivary_gland_neoplasm Accessed on November 8, 2015

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