STAG2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Cohesin subunit SA-2''' is a [[protein]] that in humans is encoded by the ''STAG2'' [[gene]].<ref name="pmid9305759">{{cite journal | vauthors = Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D | title = SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs | journal = Gene | volume = 195 | issue = 2 | pages = 151–9 | date = August 1997 | pmid = 9305759 | pmc =  | doi = 10.1016/S0378-1119(97)00121-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STAG2 stromal antigen 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10735| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Stromal antigen 2
| HGNCid = 11355
| Symbol = STAG2
| AltSymbols =; DKFZp686P168; DKFZp781H1753; FLJ25871; SA-2; SA2; bA517O1.1
| OMIM = 604359
| ECnumber = 
| Homologene = 38206
| MGIid = 1098583
| GeneAtlas_image1 = PBB_GE_STAG2_209022_at_tn.png
| GeneAtlas_image2 = PBB_GE_STAG2_207983_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_STAG2_209023_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0008150 |text = biological_process}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10735
    | Hs_Ensembl = ENSG00000101972
    | Hs_RefseqProtein = NP_001036214
    | Hs_RefseqmRNA = NM_001042749
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 122922236
    | Hs_GenLoc_end = 123064187
    | Hs_Uniprot = Q8N3U4
    | Mm_EntrezGene = 20843
    | Mm_Ensembl = ENSMUSG00000025862
    | Mm_RefseqmRNA = NM_001077712
    | Mm_RefseqProtein = NP_001071180
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 38395700
    | Mm_GenLoc_end = 38520801
    | Mm_Uniprot = Q3TG33
  }}
}}
'''Stromal antigen 2''', also known as '''STAG2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STAG2 stromal antigen 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10735| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
STAG2 has been shown to [[Protein-protein interaction|interact]] with [[STAG1]].<ref name=pmid11076961>{{cite journal | vauthors = Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM | title = Characterization of vertebrate cohesin complexes and their regulation in prophase | journal = The Journal of Cell Biology | volume = 151 | issue = 4 | pages = 749–62 | date = November 2000 | pmid = 11076961 | pmc = 2169443 | doi = 10.1083/jcb.151.4.749 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wu C, Friedlander P, Lamoureux C, Zannis-Hadjopoulos M, Price GB | title = cDNA clones contain autonomous replication activity | journal = Biochimica et Biophysica Acta | volume = 1174 | issue = 3 | pages = 241–57 | date = September 1993 | pmid = 7690594 | doi = 10.1016/0167-4781(93)90193-h }}
| citations =
* {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = September 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
*{{cite journal | author=Wu C, Friedlander P, Lamoureux C, ''et al.'' |title=cDNA clones contain autonomous replication activity. |journal=Biochim. Biophys. Acta |volume=1174 |issue= 3 |pages= 241-57 |year= 1993 |pmid= 7690594 |doi= }}
* {{cite journal | vauthors = Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM | title = Characterization of vertebrate cohesin complexes and their regulation in prophase | journal = The Journal of Cell Biology | volume = 151 | issue = 4 | pages = 749–62 | date = November 2000 | pmid = 11076961 | pmc = 2169443 | doi = 10.1083/jcb.151.4.749 }}
*{{cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi= }}
* {{cite journal | vauthors = Gregson HC, Schmiesing JA, Kim JS, Kobayashi T, Zhou S, Yokomori K | title = A potential role for human cohesin in mitotic spindle aster assembly | journal = The Journal of Biological Chemistry | volume = 276 | issue = 50 | pages = 47575–82 | date = December 2001 | pmid = 11590136 | doi = 10.1074/jbc.M103364200 }}
*{{cite journal  | author=Carramolino L, Lee BC, Zaballos A, ''et al.'' |title=SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. |journal=Gene |volume=195 |issue= 2 |pages= 151-9 |year= 1997 |pmid= 9305759 |doi=  }}
* {{cite journal | vauthors = Prieto I, Pezzi N, Buesa JM, Kremer L, Barthelemy I, Carreiro C, Roncal F, Martinez A, Gomez L, Fernandez R, Martinez-A C, Barbero JL | title = STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis | journal = EMBO Reports | volume = 3 | issue = 6 | pages = 543–50 | date = June 2002 | pmid = 12034751 | pmc = 1084142 | doi = 10.1093/embo-reports/kvf108 }}
*{{cite journal | author=Sumara I, Vorlaufer E, Gieffers C, ''et al.'' |title=Characterization of vertebrate cohesin complexes and their regulation in prophase. |journal=J. Cell Biol. |volume=151 |issue= 4 |pages= 749-62 |year= 2000 |pmid= 11076961 |doi= }}
* {{cite journal | vauthors = Lara-Pezzi E, Pezzi N, Prieto I, Barthelemy I, Carreiro C, Martínez A, Maldonado-Rodríguez A, López-Cabrera M, Barbero JL | title = Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 8 | pages = 6553–9 | date = February 2004 | pmid = 14660624 | doi = 10.1074/jbc.M307663200 }}
*{{cite journal | author=Gregson HC, Schmiesing JA, Kim JS, ''et al.'' |title=A potential role for human cohesin in mitotic spindle aster assembly. |journal=J. Biol. Chem. |volume=276 |issue= 50 |pages= 47575-82 |year= 2002 |pmid= 11590136 |doi= 10.1074/jbc.M103364200 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = August 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Prieto I, Pezzi N, Buesa JM, ''et al.'' |title=STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis. |journal=EMBO Rep. |volume=3 |issue= 6 |pages= 543-50 |year= 2003 |pmid= 12034751 |doi= 10.1093/embo-reports/kvf108 }}
* {{cite journal | vauthors = Hauf S, Roitinger E, Koch B, Dittrich CM, Mechtler K, Peters JM | title = Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2 | journal = PLoS Biology | volume = 3 | issue = 3 | pages = e69 | date = March 2005 | pmid = 15737063 | pmc = 1054881 | doi = 10.1371/journal.pbio.0030069 }} {{open access}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = McGuinness BE, Hirota T, Kudo NR, Peters JM, Nasmyth K | title = Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells | journal = PLoS Biology | volume = 3 | issue = 3 | pages = e86 | date = March 2005 | pmid = 15737064 | pmc = 1054882 | doi = 10.1371/journal.pbio.0030086 }} {{open access}}
*{{cite journal  | author=Lara-Pezzi E, Pezzi N, Prieto I, ''et al.'' |title=Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6553-9 |year= 2004 |pmid= 14660624 |doi= 10.1074/jbc.M307663200 }}
* {{cite journal | vauthors = Losada A, Yokochi T, Hirano T | title = Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts | journal = Journal of Cell Science | volume = 118 | issue = Pt 10 | pages = 2133–41 | date = May 2005 | pmid = 15855230 | doi = 10.1242/jcs.02355 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Hauf S, Roitinger E, Koch B, ''et al.'' |title=Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2. |journal=PLoS Biol. |volume=3 |issue= 3 |pages= e69 |year= 2006 |pmid= 15737063 |doi= 10.1371/journal.pbio.0030069 }}
*{{cite journal | author=McGuinness BE, Hirota T, Kudo NR, ''et al.'' |title=Shugoshin prevents dissociation of cohesin from centromeres during mitosis in vertebrate cells. |journal=PLoS Biol. |volume=3 |issue= 3 |pages= e86 |year= 2006 |pmid= 15737064 |doi= 10.1371/journal.pbio.0030086 }}
*{{cite journal  | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal | author=Losada A, Yokochi T, Hirano T |title=Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts. |journal=J. Cell. Sci. |volume=118 |issue= Pt 10 |pages= 2133-41 |year= 2006 |pmid= 15855230 |doi= 10.1242/jcs.02355 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Revision as of 07:09, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cohesin subunit SA-2 is a protein that in humans is encoded by the STAG2 gene.[1][2]

Interactions

STAG2 has been shown to interact with STAG1.[3]

References

  1. ↑ Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
  2. ↑ "Entrez Gene: STAG2 stromal antigen 2".
  3. ↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.

Further reading


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