STAG2

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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View/Edit Human

Cohesin subunit SA-2 is a protein that in humans is encoded by the STAG2 gene.[1][2]

Function

STAG2 is part of the cohesin complex, which is a structure that holds the sister chromatids together after DNA replication.[3] STAG2 has been shown to interact with STAG1.[4]

Role in Disease

Of the cohesin complex, STAG2 is the subunit where the most variants have been reported in cancer. [5] This is thought to be because this gene is located in the X chromosome, therefore only one mutation is needed to inactivate it.[6]

References

  1. Carramolino L, Lee BC, Zaballos A, Peled A, Barthelemy I, Shav-Tal Y, Prieto I, Carmi P, Gothelf Y, González de Buitrago G, Aracil M, Márquez G, Barbero JL, Zipori D (August 1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs". Gene. 195 (2): 151–9. doi:10.1016/S0378-1119(97)00121-2. PMID 9305759.
  2. "Entrez Gene: STAG2 stromal antigen 2".
  3. Mehta, Gunjan D.; Kumar, Ravinder; Srivastava, Sanjeeva; Ghosh, Santanu Kumar (2013-08-02). "Cohesin: Functions beyond sister chromatid cohesion". FEBS Letters. 587 (15): 2299–2312. doi:10.1016/j.febslet.2013.06.035. ISSN 1873-3468. PMID 23831059.
  4. Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase". The Journal of Cell Biology. 151 (4): 749–62. doi:10.1083/jcb.151.4.749. PMC 2169443. PMID 11076961.
  5. Cosmic. "STAG2 Gene - COSMIC". cancer.sanger.ac.uk. Retrieved 2018-02-13.
  6. Kim, Jung-Sik; He, Xiaoyuan; Orr, Bernardo; Wutz, Gordana; Hill, Victoria; Peters, Jan-Michael; Compton, Duane A.; Waldman, Todd (2016-02-12). "Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2". PLOS Genetics. 12 (2): e1005865. doi:10.1371/journal.pgen.1005865. ISSN 1553-7404. PMC 4752446. PMID 26871722.

Further reading