ST8SIA2

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
Identifiers
Symbols	ST8SIA2 ; HsT19690; MGC116854; MGC116857; SIAT8B; ST8SIA-II; STX
External IDs	Template:OMIM5 Template:MGI HomoloGene: 4384
Gene ontology Molecular function Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE ST8SIA2 221285 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2, also known as ST8SIA2, is a human gene.

The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.

Further reading

• Scheidegger EP, Sternberg LR, Roth J, Lowe JB (1995). "A human STX cDNA confers polysialic acid expression in mammalian cells". J. Biol. Chem. 270 (39): 22685–8. PMID 7559389.CS1 maint: Multiple names: authors list (link)
• Munro S (1995). "An investigation of the role of transmembrane domains in Golgi protein retention". EMBO J. 14 (19): 4695–704. PMID 7588599.
• Kitagawa H, Paulson JC (1994). "Differential expression of five sialyltransferase genes in human tissues". J. Biol. Chem. 269 (27): 17872–8. PMID 8027041.
• Kojima N, Tachida Y, Yoshida Y, Tsuji S (1996). "Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase. Requirement of core alpha1,6-linked fucose and a polypeptide chain for polysialylation". J. Biol. Chem. 271 (32): 19457–63. PMID 8702635.CS1 maint: Multiple names: authors list (link)
• Angata K, Nakayama J, Fredette B; et al. (1997). "Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST". J. Biol. Chem. 272 (11): 7182–90. PMID 9054414.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Close BE, Colley KJ (1999). "In vivo autopolysialylation and localization of the polysialyltransferases PST and STX". J. Biol. Chem. 273 (51): 34586–93. PMID 9852130.
• Angata K, Suzuki M, McAuliffe J; et al. (2000). "Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III". J. Biol. Chem. 275 (24): 18594–601. doi:10.1074/jbc.M910204199. PMID 10766765.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Close BE, Wilkinson JM, Bohrer TJ; et al. (2002). "The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule". Glycobiology. 11 (11): 997–1008. PMID 11744634.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Angata K, Suzuki M, Fukuda M (2002). "ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes". J. Biol. Chem. 277 (39): 36808–17. doi:10.1074/jbc.M204632200. PMID 12138100.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lazzell DR, Belizaire R, Thakur P; et al. (2005). "SV2B regulates synaptotagmin 1 by direct interaction". J. Biol. Chem. 279 (50): 52124–31. doi:10.1074/jbc.M407502200. PMID 15466855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beecken WD, Engl T, Ogbomo H; et al. (2005). "Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells". Int. Immunopharmacol. 5 (4): 757–69. doi:10.1016/j.intimp.2004.12.009. PMID 15710344.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Arai M, Yamada K, Toyota T; et al. (2006). "Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia". Biol. Psychiatry. 59 (7): 652–9. doi:10.1016/j.biopsych.2005.08.016. PMID 16229822.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)